Blar i forfatter "Andersen, Sigve"

Viser treff 21-40 av 51

    • High progesterone receptor expression in prostate cancer is associated with clinical failure 

      Grindstad, Thea; Andersen, Sigve; Al-Saad, Samer; Dønnem, Tom; Kiselev, Yury; Melbø-Jørgensen, Christian; Skjefstad, Kaja; Busund, Lill-Tove; Bremnes, Roy M.; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-27)
      Background Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the ...

    • High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome 

      Stenvold, Helge; Dønnem, Tom; Andersen, Sigve; Al-Saad, Samer; Valkov, Andrey Yurjevich; Pedersen, Mona Irene; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Hypoxic markers and prognosis in non-small cell lung cancer (NSCLC) 

      Andersen, Sigve (Doctoral thesis; Doktorgradsavhandling, 2011-11-30)
      Lungekreft er uten sammenligning den kreftsykdommen som tar flest liv i Norge og 6 personer dør i gjennomsnitt hver dag av sykdommen. De som blir oppdaget i et tidlig stadium kan opereres med mål om å bli kurert. Likevel dør nesten halvparten av de som blir operert av lungekreft og behovet for nye behandlingsalternativer er stort. Andersens funn viser at markører for lave surstoff nivåer og ...

    • The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer 

      Al-Saad, Samer; Richardsen, Elin; Kilvær, Thomas Karsten; Dønnem, Tom; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
      Introduction: <br> To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated. <br>Materials and ...

    • Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Lombardi, Ana Paola; Pøhl, Mette; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Pezzella, Francesco; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ...

    • Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer 

      Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes of such candidate miRNAs could be detected. We identified upregulated ...

    • Independent and Tissue-Specific Prognostic Impact of miR-126 in Nonsmall Cell Lung Cancer 

      Dønnem, Tom; Lønvik, Kenneth; Eklo, Katrine; Berg, Thomas; Sørbye, Sveinung Wergeland; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression ...

    • The Longitudinal Course of Prospectively Recorded Patient-reported Outcomes in Prostate Cancer Patients Treated with Surgery and Salvage Radiotherapy 

      Hjelle, Line Veronika; Sælen, Marie; Aarsæther, Erling Johan; Knutsen, Tore; Andersen, Sigve; Bentzen, Anne Gry; Richardsen, Elin; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Background - Patient-reported outcome measures (PROMs) after prostate cancer (PC) treatment, including both radical prostatectomy (RP) and salvage radiation therapy (SRT), are under-reported.<p> <p>Objective - To investigate PROMs longitudinally from before SRT until 18 mo after SRT for men treated with contemporary treatment modalities.<p> <p>Design, setting, and participants - This prospective, ...

    • Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer 

      Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Ingebriktsen, Lise; Fassina, Ambrogio; Tasken, Kristin Austlid; Millls, Ian; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that expression of immune checkpoint proteins are directly or indirectly repressed by microRNAs (miRs) in many types of cancers. The great advantages of using miRs based therapy is the capacity of these short transcripts to target multiple molecules ...

    • MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer 

      Richardsen, Elin; Andersen, Sigve; Melbø-Jørgensen, Christian; Rakaee, Mehrdad; Ness, Nora; Al-Saad, Samer; Nordby, Yngve; Pedersen, Mona Irene; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
      A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...

    • MicroRNA Signatures in Tumor Tissue Related to Angiogenesis in Non-Small Cell Lung Cancer 

      Dønnem, Tom; Fenton, Christopher Graham; Lønvik, Kenneth; Berg, Thomas; Eklo, Katrine; Andersen, Sigve; Stenvold, Helge; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Angiogenesis is regarded as a hallmark in cancer development, and anti-angiogenic treatment is presently used in non-small cell lung cancer (NSCLC) patients. MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC. From a large cohort of 335 NSCLC patients, ...

    • Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival 

      Eilertsen, Marte; Andersen, Sigve; Al-Saad, Samer; Kiselev, Yury; Dønnem, Tom; Stenvold, Helge; Pettersen, Ingvild; Al-Shibli, Khalid; Richardsen, Elin; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer — A Multi-Institutional Study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Donnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Busund, Lill-Tove R.; Richardsen, Elin (Master thesis; Mastergradsoppgave; Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      <p><i>Background:</i> MicroRNAs (miRs) have critical regulatory roles in cell functions, and are involved in prostate cancer tumorigenesis. miR-20a-5p is a member of the oncogenic miR-17-92 cluster. Overexpressed miR-20a-5p has been shown to increase both cell proliferation and cell migration in cancers. The aim of our cohort study was to evaluate the prognostic role of miR-20a-5p in prostate cancer. ...

    • Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Dønnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-14)
      <i>Objective</i>: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study.<br><br> <i>Methods</i>: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. In situ hybridization was performed to assess the expression level of miR-20a-5p in different tissue subregions: tumor stroma (TS) and tumor epithelium (TE). ...

    • Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival 

      Andersen, Sigve; Dønnem, Tom; Stenvold, Helge; Al-Saad, Samer; Al-Shibli, Khalid Ibrahim; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC. Tumor tissue samples from 335 resected stages I to IIIA NSCLC patients was obtained and tissue ...

    • PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care 

      Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Andersen, Sigve; Brunelli, Cinzia; Dajani, Olav; Ahmed, Herish; Hamre, Hanne Mari; Haukland, Ellinor Christin; Holmberg, Mats; Jordal, Frode; Krogstad, Hilde; Lundeby, Tonje; Løhre, Erik T; Mjåland, Svein; Nordbø, Arve; Paulsen, Ørnulf; Staff, Erik Schistad; Wester, Torunn; Kaasa, Stein; Loge, Jon Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      <p><i>Background - </i>Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in anticancer treatments and the high number of patients living longer with advanced disease have accentuated this. Internationally, there is now a persuasive argument that ...

    • Patient-reported outcomes after curative treatment for prostate cancer with prostatectomy, primary radiotherapy or salvage radiotherapy 

      Sælen, Marie Grøn; Hjelle, Line Veronika; Aarsæther, Erling Johan; Knutsen, Tore; Andersen, Sigve; Bentzen, Anne Gry; Richardsen, Elin; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-24)
      Trials reporting adverse health outcomes (AHOs) in terms of patient-reported outcome measures (PROMs) after contemporary curative treatment of prostate cancer (PC) are hampered by study heterogeneity and lack of new treatment techniques. Particularly, the evidence regarding toxicities after radiotherapy (RT) with the volumetric arc therapy (VMAT) technique is limited, and comparisons between men ...

    • Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression 

      Grindstad, Thea K.W.; Richardsen, Elin; Andersen, Sigve; Skjefstad, Kaja Konstanse; Rakaee, Mehrdad; Dønnem, Tom; Ness, Nora; Nordby, Yngve; Bremnes, Roy M.; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...

    • Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer 

      Rakaee, Mehrdad; Busund, Lill-Tove; Paulsen, Erna-Elise; Richardsen, Elin; Al-Saad, Samer; Andersen, Sigve; Dønnem, Tom; Bremnes, Roy M.; Kilvær, Thomas Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Recent data indicate that tumor-associated neutrophils (TANs) serve a dual role in tumor progression and regression. CD66b is a neutrophil marker and has been associated with patient outcome in various cancers. However, its clinical impact in non-small cell lung cancer (NSCLC) remains controversial. 536 NSCLC patients, of which 172 harbored lymph node metastases, were included in this study. Tissue ...

    • The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study 

      Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Berg, Thomas; Halvorsen, Tarje Onsøien; Ottestad, Anine Larsen; Lund-Iversen, Marius; Brustugun, Odd; Førde, Dagny; Paulsen, Erna-Elise; Donnem, Tom; Andersen, Sigve; Grønberg, Bjørn Henning; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)
      Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate the frequency of KRAS mutations and their associations with clinical characteristics and outcome. Since mutation subtypes have different preferences for downstream pathways, we ...