• A novel use of the leukocyte coping capacity assay to assess the immunomodulatory effects of organohalogenated contaminants in avian wildlife 

      Hansen, Elisabeth; Huber, Nikolaus; Bustnes, Jan Ove; Herzke, Dorte; Bårdsen, Bård-Jørgen; Eulaers, Igor; Johnsen, Trond Vidar; Bourgeon, Sophie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05)
      Apex predators are characterized by high levels of biomagnifying organohalogenated contaminants (OHCs) which have been found to induce detrimental health effects in wildlife, such as immune system impairment. The leukocyte coping capacity (LCC) assay is a functional real-time measure of an innate immune response essential in pathogen resistance, known as the respiratory burst. The current study ...
    • An overview of the uses of per- And polyfluoroalkyl substances (PFAS) 

      Glüge, Juliane; Scheringer, Martin; Cousins, Ian T.; Dewitt, Jamie C.; Goldenman, Gretta; Herzke, Dorte; Lohmann, Rainer; Ng, Carla A.; Trier, Xenia; Wang, Zhanyun (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-30)
      Per- and polyfluoroalkyl substances (PFAS) are of concern because of their high persistence (or that of their degradation products) and their impacts on human and environmental health that are known or can be deduced from some well-studied PFAS. Currently, many different PFAS (on the order of several thousands) are used in a wide range of applications, and there is no comprehensive source of information ...
    • Pelagic vs coastal - Key drivers of pollutant levels in Barents Sea polar bears with contrasted space-use strategies 

      Blévin, Pierre; Aars, Jon; Andersen, Magnus; Blanchet, Marie-Anne; Hanssen, Linda; Herzke, Dorte; Jeffreys, Rachel M.; Nordøy, Erling Sverre; Pinzone, Marianna; de la Vega, Camille; Routti, Heli Anna Irmeli (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-11)
      In the Barents Sea, pelagic and coastal polar bears are facing various ecological challenges that may explain the difference in their pollutant levels. We measured polychlorinated biphenyls, organochlorine pesticides, polybrominated diphenyl ethers in fat, and perfluoroalkyl substances in plasma in pelagic and coastal adult female polar bears with similar body condition. We studied polar bear feeding ...
    • Screening new PFAS compounds 2018 

      Hanssen, Linda; Herzke, Dorte; Nikiforov, Vladimir; Moe, Børge; Nygård, Torgeir; van Dijk, Jiska Joanneke; Gabrielsen, Geir W.; Fuglei, Eva; Yeung, Leo; Vogelsang, Christian; Carlsson, Pernilla Marianne (Research report; Forskningsrapport, 2019)
      This screening project has focused on the occurrence of conventional andemerging PFASs in terrestrial and marine environments, including the Arctic. Conventional PFASs were found to be wide-spread in the environment and for the first time in Norway reported in wolf, a top predator from the terrestrial environment.Otters living in close proximity to human settlements and preying on the marine food ...
    • Spatial distribution of Dechlorane Plus and dechlorane related compounds in European background air 

      Skogeng, Lovise Pedersen; Halvorsen, Helene Lunder; Breivik, Knut; Eckhardt, Sabine; Herzke, Dorte; Moeckel, Claudia; Krogseth, Ingjerd Sunde (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)
      The highly chlorinated chemical Dechlorane Plus (DP) was introduced as a replacement flame retardant for Mirex, which is banned through the Stockholm Convention (SC) for its toxicity (T), environmental persistence (P), potential for bioaccumulation (B) and long-range environmental transport potential (LRETP). Currently, Dechlorane Plus is under consideration for listing under the Stockholm Convention ...
    • Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health 

      Cousins, Ian T.; DeWitt, Jamie C.; Glüge, Juliane; Goldenman, Gretta; Herzke, Dorte; Lohmann, Rainer; Miller, Mark; Ng, Carla A.; Scheringer, Martin; Vierke, Lena; Wang, Zhanyun (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)
      Grouping strategies are needed for per- and polyfluoroalkyl substances (PFAS), in part, because it would be time and resource intensive to test and evaluate the more than 4700 PFAS on the global market on a chemical-by-chemical basis. In this paper we review various grouping strategies that could be used to inform actions on these chemicals and outline the motivations, advantages and disadvantages ...
    • Targeted PFAS analyses and Extractable Organofluorine – Enhancing our Understanding of the presence of unknown PFAS in Norwegian wildlife 

      Herzke, Dorte; Nikiforov, Vladimir; Yeung, Leo WY.; Moe, Børge; Routti, Heli Anna Irmeli; Nygård, Torgeir; Gabrielsen, Geir W.; Hanssen, Linda (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      With the current possible presence of thousands of PFAS compounds in industrial emissions, there is an increasing need to assess the impacts of PFAS regulation of conventional PFAS on one hand and the exposure to emerging and yet unknown PFAS on the other. Today’s analytical methodologies using targeted approaches are not sufficient to determine the complete suite of PFAS present. To evaluate the ...
    • Temporal Trends of Organochlorine and Perfluorinated Contaminants in a Terrestrial Raptor in Northern Europe Over 34 years (1986–2019) 

      Bustnes, Jan Ove; Bårdsen, Bård-Jørgen; Herzke, Dorte; Bangjord, Georg; Bourgeon, Sophie; Fritsch, Clémentine; Eulaers, Igor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-21)
      Fourteen legacy organochlorine (OC) contaminants and 12 perfluoroalkyl substances (PFASs) were measured in eggs of tawny owls (Strix alueco) in central Norway (1986–2019). We expected OCs to have reached stable equilibrium levels due to bans, and that recent phase-out of some PFASs would have slowed the increase of these compounds. ∑OC comprised on average approximately 92% of the measured compounds, ...
    • Total Oxidizable Precursors Assay for PFAS in Human Serum 

      Cioni, Lara; Nikiforov, Vladimir; Miranda Fernandes Coelho, Ana Carolina; Sandanger, Torkjel M; Herzke, Dorte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals including over 4700 substances. As a limited number of PFAS is routinely analyzed in human serum, complementary analytical methods are required to characterize the overlooked fraction. A promising tool is the total oxidizable precursors (TOP) assay to look for precursors by oxidation to perfluoroalkyl acids (PFAA). The TOP assay was ...
    • Trophic and fitness correlates of mercury and organochlorine compound residues in egg-laying Antarctic petrels 

      Carravieri, Alice; Warner, Nicholas Alexander; Herzke, Dorte; Brault-Favrou, Maud; Tarroux, Arnaud; Fort, Jérôme; Bustamante, Paco; Descamps, Sebastien (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-24)
      Understanding the drivers and effects of exposure to contaminants such as mercury (Hg) and organochlorine compounds (OCs) in Antarctic wildlife is still limited. Yet, Hg and OCs have known physiological and fitness effects in animals, with consequences on their populations. Here we measured total Hg (a proxy of methyl-Hg) in blood cells and feathers, and 12 OCs (seven polychlorinated biphenyls, PCBs, ...