Blar i forfatter "Knutsen, Erik"

Viser treff 21-27 av 27

    • Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling 

      Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil the underlying molecular mechanisms. We showed that metformin inhibits CRC cell proliferation by arresting ...

    • MiRNAs‐181a/b therapy in lung cancer: reality or myth? 

      Braicu, Cornelia; Gulei, Diana; Cojocneanu, Roxana Maria; Raduly, Lajos; Jurj, Ancuta; Knutsen, Erik; Calin, George Adrian; Berindan-Neagoe, Ioana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)
      Despite substantial progress in oncology, lung cancer remains the number one malignancy in terms of both incidence and mortality rates, and there thus remains an urgent need for new therapeutic alternatives. MicroRNA (miRNA) have an important role in cancer initiation and progression due to their capacity to interfere with transcriptional signaling and regulate key cellular processes. miR‐181a and ...

    • A novel lncRNA derived from an ultraconserved region: lnc- uc.147, a potential biomarker in luminal A breast cancer 

      Zambalde, Erika Pereira; Bayraktar, Recep; Jucoski, Tayana Schultz; Ivan, Cristina; Rodrigues, Ana Carolina de Mello Alves; Mathias, Carolina; Knutsen, Erik; Silveira de Lima, Rubens; Gradia, Daniela Fiori; Fonseca, Enilze Maria de Souza; Hannash, Samir; Calin, George A.; Oliveira, Jaqueline Carvalhode (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-13)
      The human genome contains 481 ultraconserved regions (UCRs), which are genomic stretches of over 200 base pairs conserved among human, rat, and mouse. The majority of these regions are transcriptionally active (T-UCRs), and several have been found to be differentially expressed in tumours. Some T-UCRs have been functionally characterized, but of those few have been associated to breast cancer (BC). ...

    • Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines 

      Knutsen, Erik; Fiskaa, Tonje; Ursvik, Anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were ...

    • Proteoglycans Determine the Dynamic Landscape of EMT and Cancer Cell Stemness 

      Karagiorgou, Zoi; Fountas, Panagiotis N; Manou, Dimitra; Knutsen, Erik; Theocharis, Achilleas D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-29)
      Proteoglycans (PGs) are pivotal components of extracellular matrices, involved in a variety of processes such as migration, invasion, morphogenesis, differentiation, drug resistance, and epithelial-to-mesenchymal transition (EMT). Cellular plasticity is a crucial intermediate phenotypic state acquired by cancer cells, which can modulate EMT and the generation of cancer stem cells (CSCs). PGs ...

    • Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue 

      Tellez Gabriel, Marta; Tekpli, Xavier; Reine, Trine M.; Hegge, Beate; Nielsen, Stephanie Rose; Chen, Meng; Moi, Line; Normann, Lisa Svartdal; Rasmussen Busund, Lill-Tove; Calin, George A.; Mælandsmo, Gunhild Mari; Perander, Maria; Theocharis, Achilleas D.; Kolset, Svein Olav; Knutsen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of ...

    • Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report 

      Brun, Vegard Heimly; Knutsen, Erik; Stenvold, Helge; Halvorsen, Hanne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
      Background - Hypercalcemia of malignancy is relatively common in several cancers. However, in colorectal cancer, paraneoplastic phenomena that cause hypercalcemia is uncommon. In the few cases that are reported, secretion of parathyroid hormone-related peptide mediates the effect. We describe the first case of severe hypercalcemia mediated by intact parathyroid hormone secretion from a bone metastasis ...