• Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex 

      Pottel, Hans; Björk, Jonas; Rule, Andrew D.; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Vidal-Petiot, Emmanuelle; Grubb, Anders; Hansson, Magnus; Lamb, Edmund J.; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Flamant, Martin; Nyman, Ulf; Delanaye, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)
      BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ...
    • Extending the Lund-Malmö creatinine-based GFR equation to cystatin C–validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults 

      Björk, Jonas; Nyman, Ulf; Berg, Ulla; Bökenkamp, Arend; Cavalier, Etienne; Ebert, Natalie; Eriksen, Bjørn Odvar; Derain Dubourg, Laurence; Goffin, Karolien; Grubb, Anders; Hansson, Magnus; Larsson, Anders; Lemoine, Sandrine; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åsling-Monemi, Kajsa; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)
      The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMR<sub>Cys</sub>) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy ...
    • Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol? 

      Delanaye, Pierre; Melsom, Toralf; Ebert, Natalie; Bäck, Sten-Erik; Mariat, Christophe; Cavalier, Etienne; Björk, Jonas; Christensson, Anders; Nyman, Ulf; Porrini, Esteban; Remuzzi, Giuseppe; Ruggenenti, Piero; Schaeffner, Elke; Soveri, Inga; Sterner, Gunnar; Eriksen, Bjørn Odvar; Gasperi, Flavia (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)
      A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the ...
    • Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol? 

      Delanaye, Pierre; Ebert, Natalie; Melsom, Toralf; Gasperi, Flavia; Mariat, Christophe; Cavalier, Etienne; Björk, Jonas; Christensson, Anders; Nyman, Ulf; Porrini, Esteban; Remuzzi, Giuseppe; Ruggenenti, Piero; Schaeffner, Elke; Soveri, Inga; Sterner, Gunnar; Eriksen, Bjørn Odvar; Bäck, Sten-Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)
      While there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose.As the gold standardmethod for GFR determination, urinary (or renal) clearance of inulin, fades into the background due to inconvenience and high cost, a diversity of filtrationmarkers and protocols compete to ...
    • Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium 

      Ebert, Natalie; Schaeffner, Elke; Seegmiller, Jesse C.; van Londen, Marco; Bökenkamp, Arend; Cavalier, Etienne; Delanaye, Pierre; Derain-Dubourg, Laurence; Eriksen, Bjørn Odvar; Indridason, Olafur S.; Palsson, Runolfur; Shafi, Tariq; Christensson, Anders; Bevc, Sebastjan; Carrara, Fabiola; Courbebaisse, Marie; Dalton, R. Neil; van der Giet, Markus; Melsom, Toralf; Methven, Shona; Nordin, Gunnar; Pottel, Hans; Rule, Andrew D.; Trillini, Matias; White, Christine A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-07)
      International consensus supports the development of standardized protocols for measured glomerular filtration rate (mGFR) to facilitate the integration of mGFR testing in both clinical and research settings. To this end, the European Kidney Function Consortium convened an international group of experts with relevant experience in mGFR. The working group performed an extensive literature search to ...
    • Iohexol Plasma Clearance: Impact of Weighing the Syringe 

      Delanaye, Pierre; Melsom, Toralf; Cavalier, Etienne; Pottel, Hans; Eriksen, Bjørn Odvar; Dubourg, Laurence (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-05)
      Measured glomerular filtration rate (mGFR) measurement is necessary in specific patients and/or specific clinical contexts.1–3 Plasma clearances are the preferred methods, as they are less costly and cumbersome than urinary clearances.4 The contrast medium iohexol is the most commonly used worldwide, partly for pragmatic reasons, as this marker is stable, not radioactive, and its measurement ...
    • Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa 

      Delanaye, Pierre; Vidal-Petiot, Emmanuelle; Björk, Jonas; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Grubb, Anders; Hansson, Magnus; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla B.; Åsling-Monemi, Kajsa; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Dalton, R Neil; Courbebaisse, Marie; Couzi, Lionel; Gaillard, Francois; Garrouste, Cyril; Jacquemont, Lola; Kamar, Nassim; Legendre, Christophe; Rostaing, Lionel; Stehlé, Thomas; Haymann, Jean-Philippe; Selistre, Luciano da Silva; Strogoff-de-Matos, Jorge P.; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Nyman, Ulf; Pottel, Hans; Flamant, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Background - A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.<p> <p>Methods - Standardized creatinine and measured glomerular ...