• Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae 

      Tsang, Kara K.; Lam, Margaret M C; Wick, Ryan R.; Wyres, Kelly L.; Bachman, Michael; Baker, Stephen; Barry, Katherine; Brisse, Sylvain; Campino, Susana; Chiaverini, Alexandra; Cirillo, Daniela Maria; Clark, Taane; Corander, Jukka; Corbella, Marta; Cornacchia, Alessandra; Cuénod, Aline; D'Alterio, Nicola; Di Marco, Federico; Donado-Godoy, Pilar; Egli, Adrian; Farzana, Refath; Feil, Edward J.; Fostervold, Aasmund; Gorrie, Claire L.; Hassan, Brekhna; Hetland, Marit; Hoa, Le Nguyen Minh; Hoi, Le Thi; Howden, Benjamin; Ikhimiukor, Odion O.; Jenney, Adam W J; Kaspersen, Håkon; Khokhar, Fahad; Leangapichart, Thongpan; Ligowska-Marzęta, Małgorzata; Löhr, Iren Høyland; Long, Scott W.; Mathers, Amy J.; McArthur, Andrew G.; Nagaraj, Geetha; Oaikhena, Anderson O.; Okeke, Iruka N.; Perdigão, João; Parikh, Hardik; Pham, My H.; Pomilio, Francesco; Raffelsberger, Niclas Peter; Rakotondrasoa, Andriniaina; Kumar, K L Ravi; Roberts, Leah W.; Rodrigues, Carla; Samuelsen, Ørjan; Sands, Kirsty; Sassera, Davide; Seth-Smith, Helena; Shamanna, Varun; Sherry, Norelle L.; Sia, Sonia; Spadar, Anton; Stoesser, Nicole; Sunde, Marianne; Sundsfjord, Arnfinn Ståle; Thach, Pham Ngoc; Thomson, Nicholas R.; Thorpe, Harry; Torok, M Estée; Trang, Van Dinh; Trung, Nguyen Vu; Vornhagen, Jay; Walsh, Timothy; Warne, Ben; Wilson, Hayley; Wright, Gerard D.; Holt, Kathryn E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-21)
      Interpreting the phenotypes of bla<sub>SHV</sub> alleles in Klebsiella pneumoniae genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal bla<sub>SHV</sub> alleles or additional plasmid-borne bla<sub>SHV</sub> alleles that have extended-spectrum β-lactamase (ESBL) activity and/ or β-lactamase ...
    • Taking hospital pathogen surveillance to the next level 

      Werner, Guido; Couto, Natacha; Feil, Edward J.; Novais, Angela; Hegstad, Kristin; Howden, Benjamin P.; Friedrich, Alexander W.; Reuter, Sandra (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      High-throughput bacterial genomic sequencing and subsequent analyses can produce large volumes of high-quality data rapidly. Advances in sequencing technology, with commensurate developments in bioinformatics, have increased the speed and efficiency with which it is possible to apply genomics to outbreak analysis and broader public health surveillance. This approach has been focused on targeted ...