Blar i forfatter "Marschall, Manfred"

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    • An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity 

      Yu, DongHoon; Wagner, Sabrina; Schütz, Martin; Jeon, Yeejin; Seo, Mooyoung; Kim, Jaeseung; Brückner, Nadine; Kicuntod, Jintawee; Tillmanns, Julia; Wangen, Christina; Hahn, Friedrich; Kaufer, Benedikt B.; Neipel, Frank; Eickhoff, Jan; Klebl, Bert; Nam, Kiyean; Marschall, Manfred (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-23)
      he repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type 2 (SARS-CoV-2 or COVID-19), human immunodeficiency virus type 1 (HIV-1 or AIDS), and the pregnancy- and posttransplant-relevant human cytomegalovirus (HCMV). In almost ...

    • Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target 

      Tillmanns, Julia; Häge, Sigrun; Borst, Eva Maria; Wardin, Julia; Eickhoff, Jan; Klebl, Bert; Wagner, Sabrina; Wangen, Christina; Hahn, Friedrich; Socher, Eileen; Marschall, Manfred (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-14)
      Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a multistageregulated export pathway through the nuclear lamina and both leaflets of the nuclear membrane has evolved. This process involves regulatory proteins, which support the local distortion of the ...