• SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease 

      Salgueiro, Bruno A.; Saramago, Margarida; Tully, Mark D.; Issoglio, Federico; Silva, Sara T. N.; Paiva, Ana C. F.; Arraiano, Cecília M.; Matias, Pedro M.; Matos, Rute G.; Moe, Elin; Romão, Célia V. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-28)
      Over recent years, we have been living under a pandemic, caused by the rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). One of the major virulence factors of Coronaviruses is the Non-structural protein 1 (Nsp1), known to suppress the host cells protein translation machinery, allowing the virus to produce its own proteins, propagate and invade new cells. To ...