Blar i forfatter "Pettersen Jevne, Ina"

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    • Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+ 

      Høyland, Lena Elise; Van Linden, Magali R; Niere, Marc; Strømland, Øyvind; Ziegler, Mathias; Ashrafi, Hanan; Haukanes, Kjellfrid Fosso; de Jesus Lucena Toro, Eva Maria; Bifulco, Ersilia; Mjøs, Svein Are; Sverkeli, Lars Jansen; Davidsen, Cedric; Tolås, Ingvill; van der Hoeven, Barbara; Dietze, Jörn Lukas Franz; Heiland, Ines; Cimadamore-Wer, Camila; Dölle, Christian; Pettersen Jevne, Ina; Tronstad, Karl Johan; Hayat, Faisal; Sharma, Suraj; Makarov, Mikhail V.; Migaud, Marie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-13)
      The coenzyme NAD<sup>+</sup> is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD<sup>+</sup> levels, but how cells cope with persistently decreased NAD<sup>+</sup> concentrations is unclear. Here, we show that subcellular NAD<sup>+</sup> pools are interconnected, with mitochondria acting as a rheostat ...