Blar i forfatter "Saha, Bhaskar"

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    • TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform 

      Kehl, Stephanie R; Soos, Brandy-Lee A; Saha, Bhaskar; Choi, Seong Won; Herren, Anthony W; Johansen, Terje; Mandell, Michael A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-25)
      The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro‐inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here, we show that TAK1, a kinase involved in immune signaling, negatively regulates p62 action in autophagy. TAK1 reduces p62 ...

    • TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery 

      Saha, Bhaskar; Olsvik, Hallvard Lauritz; Williams, Geneva L.; Oh, Seeun; Evjen, Gry; Sjøttem, Eva Synnøve; Mandell, Michael A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-29)
      Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is essential for its mitophagy functions. This modification is catalyzed by the ubiquitin ligase TRIM5a and is ...