Blar i forfatter "Wessel, Øystein"

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    • Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes 

      Wessel, Øystein; Krasnov, Aleksei; Timmerhaus, Gerrit; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-16)
      Salmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle ...

    • Comparison of transcriptome responses in blood cells of Atlantic salmon infected by three genotypes of Piscine orthoreovirus 

      Tsoulia, Thomais; Sundaram, Arvind; Amundsen, Marit Måsøy; Rimstad, Espen; Wessel, Øystein; Jørgensen, Jorunn B; Dahle, Maria Krudtå (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-09)
      Piscine orthoreovirus (PRV) infection is common in aquaculture of salmonids. The three known PRV genotypes (PRV-1-3) have host species specificity and cause different diseases, but all infect and replicate in red blood cells (RBCs) in early infection phase. PRV-1 is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar), PRV-2 causes erythrocytic ...

    • Dissemination of Piscine orthoreovirus-1 (PRV-1) in Atlantic Salmon (Salmo salar) during the Early and Regenerating Phases of Infection 

      Dhamotharan, Kannimuthu; Bjørgen, Håvard; Malik, Muhammad Salman; Nyman, Ingvild Berg; Markussen, Turhan Ali Dadasbilge; Dahle, Maria; Koppang, Erling Olaf; Wessel, Øystein; Rimstad, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-20)
      <i>Piscine orthoreovirus-1</i> (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (<i>Salmo salar</i>), but the line of events from infection, pathologic change, and regeneration has not been thoroughly described. In this study, the cellular localization and variation of PRV-1 RNA and protein levels were analyzed at different times post-exposure in experimentally ...

    • Piscine Orthoreovirus (PRV)-3, but Not PRV-2, Cross-Protects against PRV-1 and Heart and Skeletal Muscle Inflammation in Atlantic Salmon 

      Malik, Muhammad Salman; Teige, Lena Hammerlund; Braaen, Stine; Olsen, Anne Berit; Nordberg, Monica; Amundsen, Marit; Kannimuthu, Dhamotharan; Svenning, Steingrim; Edholm, Eva-Stina Isabella; Takano, Tomokazu; Jørgensen, Jorunn; Wessel, Øystein; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-06)
      Heart and skeletal muscle inflammation (HSMI), caused by infection with Piscine orthoreovirus-1 (PRV-1), is a common disease in farmed Atlantic salmon (Salmo salar). Both an inactivated whole virus vaccine and a DNA vaccine have previously been tested experimentally against HSMI and demonstrated to give partial but not full protection. To understand the mechanisms involved in protection against HSMI ...

    • Transcriptomics of early responses to purified Piscine orthoreovirus-1 in Atlantic salmon (Salmo salar L.) red blood cells compared to non-susceptible cell lines 

      Tsoulia, Thomais; Sundaram, Arvind Y. M.; Braaen, Stine; Jørgensen, Jorunn B; Rimstad, Espen; Wessel, Øystein; Dahle, Maria Krudtå (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-14)
      Piscine red blood cells (RBC) are nucleated and have been characterized as mediators of immune responses in addition to their role in gas exchange. Salmonid RBC are major target cells of Piscine orthoreovirus-1 (PRV-1), the etiological agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). PRV-1 replicates in RBC ex vivo, but no viral amplification has been ...