Viser treff 11761-11780 av 36353

    • Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study 

      Nordström, Anna Hava; Nordström, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-30)
      Background<p> <p>Traumatic brain injury (TBI) has been associated with dementia. The questions of whether the risk of dementia decreases over time after TBI, whether it is similar for different TBI types, and whether it is influenced by familial aggregation are not well studied. <p>Methods and findings <p>The cohort considered for inclusion comprised all individuals in Sweden aged 50 years ...
    • WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport 

      Rainsford, Philip Ben; Sarre, Birta R.; Falavigna, Margherita; Brandsdal, Bjørn Olav; Flaten, Gøril Eide; Jakubec, Martin; Isaksson, Johan Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-22)
      Water/Ion NMR Detected – Phospholipid Vesicle Permeability Assay (WIND-PVPA), is presented as a novel, straightforward and automatable method to assess lipid barrier integrity in vitro. The apparent permeability constants of water- and ions across the PVPA barriers are determined in a one-pot experiment under the influence of membrane-active guest molecules. NMR spectroscopy is used to quantify ...
    • A reply to calls for an extension of the definitoin of Sami in Finland 

      Åhren, Jon Matthias; Aikio, Antti (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-04-30)
      In Finland the legal definition of the indigenous Sámi has been debated heatedly for years and more recently it has entered academic circles. Some scholars submit that the current law-based definition in Finland is all too narrow, and argue that there should be more emphasis on self-identification by the individual. Further claims state that the ILO Convention No. 169 identifies the subjects of ...
    • Expanding the toolbox for the study of antimicrobial peptides 

      Rainsford, Philip (Doctoral thesis; Doktorgradsavhandling, 2022-06-02)
      There is an urgent lack of new antibiotics in the face of an ever-expanding antimicrobial resistance crisis. The fact that fewer new classes of antibiotics are being developed, and resistance soon follows newly available antibiotics, only serves to underline the urgency of the matter. There is a clear need of a paradigm shift with regards to antibiotics, and one such hope is antimicrobial peptides ...
    • The Slottsmøya marine reptile Lagerstätte: depositional environments, taphonomy and diagenesis 

      Delsett, Lene Liebe; Novis, Linn Kristin; Roberts, Aubrey Jane; Koevoets, Maayke Jacqueline; Hammer, Øyvind; Druckenmiller, Patrick Scott; Hurum, Jørn Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-16)
      The Late Jurassic Slottsmøya Member Lagersta¨tte on Spitsbergen offers a unique opportunity to study the relationships between vertebrate fossil preservation, invertebrate occurrences and depositional environment. In this study, 21 plesiosaurian and 17 ichthyosaur specimens are described with respect to articulation, landing mode, preservation, and possible predation and scavenging. The stratigraphic ...
    • Overdiagnosis in screening mammography in Denmark: population based cohort study 

      Njor, Sissel Helle; Olsen, Anne Helene; Blichert-Toft, Mogens; Schwartz, Walter; Vejborg, Ilse; Lynge, Elsebeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-02-26)
      Objective To use data from two longstanding, population based screening programmes to study overdiagnosis in screening mammography.<p> <p>Design Population based cohort study. <p>Setting Copenhagen municipality (from 1991) and Funen County (from 1993), Denmark. <p>Participants 57 763 women targeted by organised screening, aged 56-69 when the screening programmes started, and followed up to ...
    • Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition 

      Romieu, Isabelle; Scoccianti, Chiara; Chajès, Véronique; De Batlle, Jordi; Biessy, Carine; Dossus, Laure; Baglietto, Laura; Clavel-Chapelon, Françoise; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Kaaks, Rudolf; Lukanova, Annekatrin; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; van Gils, Carla H.; Peeters, Petra H.; Lund, Eiliv; Skeie, Guri; Weiderpass, Elisabete; García, José Ramón Quirós; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sánchez, María-José; Duell, Eric J.; Amiano, Pilar; Borgquist, Signe; Wirfält, Elisabet; Hallmans, Göran; Johansson, Ingegerd; Nilsson, Lena Maria; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Travis, Ruth C.; Murphy, Neil; Wark, Petra A.; Ferrari, Pietro; Riboli, Elio (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)
      Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into ...
    • Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations 

      Gabrielsen, Mari; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-14)
      The serotonin (5-HT) transporter (SERT) plays an important role in the termination of 5-HT-mediated neurotransmission by transporting 5-HT away from the synaptic cleft and into the presynaptic neuron. In addition, SERT is the main target for antidepressant drugs, including the selective serotonin reuptake inhibitors (SSRIs). The three-dimensional (3D) structure of SERT has not yet been determined, ...
    • The use of stated preferences and bio-economic modeling in marine ecosystem service management: Case studies from Arctic Norway 

      Ahi, Julide Ceren (Doctoral thesis; Doktorgradsavhandling, 2022-06-09)
      <p>Regarding the growing population and escalated development on the coasts, the environmental policymakers often face the dilemma of exploiting or protecting marine and coastal ecosystem services (ES). Therefore, the non-market valuation has become an essential instrument for supporting policymakers in eliciting preferences and welfare estimates regarding various ES, which further feed into the ...
    • Get out of the BAG! Silos in AI Ethics Education: Unsupervised Topic Modeling Analysis of Global AI Curricula 

      Javed, Rana Tallal; Nasir, Osama; Vanhée, Loïs; Borit, Melania; Zea, Elias; Gupta, Shivam; Vinuesa, Ricardo; Qadir, Junaid (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-26)
      The domain of Artificial Intelligence (AI) ethics is not new, with discussions going back at least 40 years. Teaching the principles and requirements of ethical AI to students is considered an essential part of this domain, with an increasing number of technical AI courses taught at several higher-education institutions around the globe including content related to ethics. By using Latent Dirichlet ...
    • Climate change in context: putting people first in the Arctic 

      Huntington, Henry P.; Carey, Mark; Apok, Charlene; Forbes, Bruce C.; Fox, Shari; Holm, Lene K; Ivanova, Aytalina; Jaypoody, Jacob; Noongwook, George; Stammler, Florian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-06)
      Climate change is a major challenge to Arctic and other Indigenous peoples, but not the only and often not the most pressing one. We propose re-framing the treatment of climate change in policy and research, to make sure health, poverty, education, cultural vitality, equity, justice, and other topics highlighted by the people themselves and not just climate science also get the attention they ...
    • The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities 

      Sarre, Aili; Stelter, Meike; Rollo, Filipe; De Bonis, Salvatore; Seck, Anna; Hognon, Cecilia; Ravanat, Jean-Luc; Monari, Antonio; Dehez, Francois; Moe, Elin; Timmins, Joanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      Endonuclease III (EndoIII) is a bifunctional DNA glycosylase that removes oxidized pyrimidines from DNA. The genome of Deinococcus radiodurans encodes for an unusually high number of DNA glycosylases, including three EndoIII enzymes (drEndoIII1-3). Here, we compare the properties of these enzymes to those of their well-studied homologues from E. coli and human. Our biochemical and mutational data, ...
    • Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix 

      Bril'kov, Maxim; Dobrovolska, Olena; Ødegård-Fougner, Øyvind; Turcu, Diana Cornelia; Strømland, Øyvind; Underhaug, Jarl; Aasland, Rein; Halskau, Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-13)
      The CW domain binds to histone tail modifications found in different protein families involved in epigenetic regulation and chromatin remodeling. CW domains recognize the methylation state of the fourth lysine on histone 3 and could, therefore, be viewed as a reader of epigenetic information. The specificity toward different methylation states such as me1, me2, or me3 depends on the particular ...
    • Monitoring bacterial community dynamics in a drinking water treatment plant: an integrative approach using metabarcoding and microbial indicators in large water volumes 

      Pinar-Méndez, Anna; Wangensteen, Owen S.; Præbel, Kim; Galofré, Belén; Méndez, Javier; Blanch, Anicet R.; García-Aljaro, Cristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
      Monitoring bacterial communities in a drinking water treatment plant (DWTP) may help to understand their regular operations. Bacterial community dynamics in an advanced full-scale DWTP were analyzed by 16S rRNA metabarcoding, and microbial water quality indicators were determined at nine different stages of potabilization: river water and groundwater intake, decantation, sand filtration, ozonization, ...
    • Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment 

      Sylte, Ole Christian; Johansen, Jesper Solheim; Heinla, Indrek; Houwing, Danielle; Olivier, Jocelien D.A.; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various afective disorders during pregnancy. SSRIs cross the placenta and afect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the ofspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social ...
    • Population cycles in small rodents seen through the lens of a wildlife camera 

      Kleiven, Eivind Flittie (Doctoral thesis; Doktorgradsavhandling, 2022-06-08)
      Population cycles in small rodents have attracted attention from ecologists for more than a century. This spectacular phenomenon is crucial for the functioning of many northern food-webs and has intrigued ecologist because of its lessons for general ecology. Knowledge about the rodent cycle has, however, been hampered by the lack of reliable monitoring methods both for rodents and some of their ...
    • For all audiences: Incorporating immature stages into standardised spider inventories has a major impact on the assessment of biodiversity patterns 

      Domènech, Marc; Wangensteen, Owen S.; Enguídanos, Alba; Malumbres-Olarte, Jagoba; Arnedo, Miquel A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)
      Although arthropods are the largest component of animal diversity, they are traditionally underrepresented in biological inventories and monitoring programmes. However, no biodiversity assessment can be considered informative without including them. Arthropod immature stages are often discarded during sorting, despite frequently representing more than half of the collected individuals. To date, ...
    • Cutoff Latitudes of Solar Proton Events Measured by GPS Satellites 

      van Hazendonk, Charlotte Maartje; Heino, Erkka Petteri; Jiggens, Piers T.A.; Taylor, Matthew G.G.T.; Partamies, Noora; Mulders, Hjalmar C. J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Solar energetic particles (SEPs), one of the main causes of particle radiation in interplanetary space, can disrupt radio communication, induce spacecraft failures and change the heating and cooling rates in the atmosphere among others. To investigate the impact of SEPs and more specifically solar proton events (SPEs), we established a cutoff latitude database based on energetic particle data from ...
    • Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity 

      Rødland, Erik; Melleby, Kathrine Midgaard; Specht, Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-03)
      The present study replicates a known visual language paradigm, and extends it to a paradigm that is independent from the sensory modality of the stimuli and, hence, could be administered either visually or aurally, such that both patients with limited sight or hearing could be examined. The stimuli were simple sentences, but required the subject not only to understand the content of the sentence but ...
    • Deep learning applied to fish otolith images 

      Martinsen, Iver (Master thesis; Mastergradsoppgave, 2021-11-14)
      This thesis is concerned with classification and regression using deep learning applied to fish otolith images. Otoliths (earstones) are calcified structures in the inner ear of vertebrates, and are used, for instance, in fish stock assessment and fish age determination. We use convolutional neural networks – a class of deep learning models - on two specific problems: discrimination between Northeast ...