Oral squamous cell carcinoma (OSCC) is an aggressive cancer associated with high mortality rates. The objective of this master project was to test the following hypotheses: (1) transforming growth factor β1 (TGFβ1) activates fibroblasts in vitro and basic fibroblast growth factor (bFGF) deactivates them while both increase fibroblast proliferation in cancer associated fibroblasts (CAFs); (2) the ...

Although the problem of cardiovascular disease (CVD) in Russia has been the subject of attention for decades, a definitive and comprehensive explanation of why the CVD burden there is so high and generally greater than in many other countries has still not been found. In this thesis, I have attempted to advance research on these issues by examining the role of blood lipids, heart damage biomarkers ...

<i>Background</i> - Non-communicable general and oral health conditions share common risk factors. Studies investigating common social determinants as risk factors for overweight/obesity and dental caries among the same adolescents are scarce and inconclusive.<p><p> <i>Methods</i> - This cross-sectional study included data from 464 girls and 494 boys from the population-based Tromsø study Fit ...

One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...

Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ...

<p><i>Background:</i> Diabetes patient associations and diabetes-specific patient groups around the world are present on social media. Although active participation and engagement in these diabetes social media groups has been mostly linked to positive effects, very little is known about the content that is shared on these channels or the post features that engage their users the most. <p><i>Objective:</i> ...

<p>Oppgaven benytter romlig plassering av steinartefakter til å belyse bruken av boliger i Vest-Grønland i perioden 2400-1500 f.kr. Tidligere arbeider fra området har i hovedsak kvantifisert artefakter og analysert redskapstyper, og fra dette utledet kronologier og hvilke arbeidsoppgaver redskapene har inngått i. I denne oppgaven brukes til en viss grad redskapsanalyser og kvantitative analyser, men ...

A solar-flare-induced, high-latitude (peak at 70–75^∘ geographic latitude – GGlat) ionospheric current system was studied. Right after the X9.3 flare on 6 September 2017, magnetic stations at 68–77^∘ GGlat near local noon detected northward geomagnetic deviations (ΔB) for more than 3 h, with peak amplitudes of >200 nT without any accompanying substorm activities. From its location, ...

The approach to standardized services in Norwegian mental health care is tailored to the needs of the majority population, focusing on diagnoses and overshadows an approach that understands, values and emphasizes Sámi storytelling and everyday life. This study aims to contribute knowledge regarding the promotion of user involvement in mental health care from the perspectives of Sámi mental health ...

Epipericardial fat necrosis (EFN), also known as pericardial or mediastinal fat necrosis, has until lately been considered an unusual cause of acute chest pain. Due to increased use of computed tomography (CT) and other imaging techniques, EFN is now believed to be an under-diagnosed cause of acute chest pain. We here present a patient with a short history of acute, left-sided pleuritic chest pain ...