The coenzyme NAD⁺ is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD⁺ levels, but how cells cope with persistently decreased NAD⁺ concentrations is unclear. Here, we show that subcellular NAD⁺ pools are interconnected, with mitochondria acting as a rheostat ...

In this paper, we present a comprehensive study of wavelet theory with a focus on structural damage detection. A new example of the application of operational modal analysis (OMA) techniques to a concrete railway arch bridge located over the Kalix river in L{\aa}ngforsen, Sweden is presented. Results from the OMA techniques are used for finite element model (FEM) updating of this concrete railway ...

The varied landscape of Sápmi – ranging from forests, coasts, mountains, tundra, and mires – and the livelihoods of those who live there have developed Sámi forms pedagogy, child-rearing, and education. This special issue explores the philosophies of Sámi education. The issue adopts a broad notion of education that involves formal and informal educational settings, kindergartens, schools and ...

Introduction: When a child has a disability, their families face significant challenges that also impact parents' and siblings' mental health and adjustment. We examined the potential bidirectional relationships between parental mental health and sibling mental health and adjustment in families of children with a disability.<p> <p>Methods: We utilized baseline and 12month follow-up data from a ...

Engineering, procurement, and construction projects are time-intensive and subject to resource constraints. Modern project planning software requires optimization algorithms to schedule tasks while considering resource availability. A comprehensive review of the optimization algorithms used in project planning has not yet been conducted. This study seeks to bridge the gap through an algorithmic ...

Den «offisielle» etikken til Kant, slik den presenteres i de etiske hovedverkene fra den kritiske og sen-kritiske perioden, er universalistisk og upartisk. Universalistisk vil si at alle mennesker er inkluderte i det moralske fellesskapet, mens upartisk betyr at etikken gjelder uavhengig av blant annet kjønnsmessige og etniske skillelinjer. I flere førkritiske verk, samt i Antropologiforelesningene, ...

Ulcerative Colitis (UC) is a chronic autoimmune inflammatory disease and one type of inflammatory bowel disease (IBD). UC is characterized by a temporal course of remission and relapse. Environmental factors, immune system dysregulation, and genetic susceptibility interact intricately in the aetiology of UC. It is unclear how interactions involving non-coding RNAs (ncRNAs), epigenetic modifications, ...

This report summarizes the findings from a price experiment survey on the willingness to pay (WTP) for salmon produced using new production systems in salmon farming in three countries (Norway, Canada and Scotland). This includes land-based, floating closed containment cages and offshore production systems. The results revealed that consumers preferred salmon produced using conventional (traditional) ...

I denne artikkelen undersøker vi hva som, tross lave søkertall og negativ medieomtale, motiverer unge mennesker til å studere sykepleie. Studien setter søkelys på skillet mellom altruistisk og egennyttig motivasjon, og sammenligner dessuten sykepleiestudenter på bakgrunn av deres kjønn, alder, tidligere arbeidserfaring og hvilken prioritet de ga studiet da de søkte. Kvantitative data ble samlet ...

Gjennom Opplæringslova (2023), Menneskerettighetene (1948) og Konvensjon for mennesker med nedsatt funksjonsevne (2006) har voksne med behov for alternativ og supplerende kommunikasjon (ASK) en lovfestet rettighet til å kommunisere. En stor utfordring for voksne som bruker ASK er ifølge Light et al. (2019) å sikre at alle med behov for ASK har tilgang til kommunikasjon. Denne kvalitative studien ...