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Vinyl Sulfoxonium Ylide: A New Vinyl Carbenoid Transfer Reagent for the Synthesis of Heterocycles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-10)Sulfoxonium ylides have recently gained prominence as safe carbenoid precursors in metal-catalyzed reactions. The stability and reactivity of sulfoxonium ylides depend on the substitution of the ylide carbon. The reactivity of vinyl-substituted sulfoxonium ylides is different and offers several advantages over known stabilized sulfoxonium ylides in the case of carbenoid transfer reactions. Herein, ... -
Barns opplevelser i krig. Skolen i møte med barn som har opplevd livstruende hendelser
(Master thesis; Mastergradsoppgave, 2019-05-14)Denne undersøkelsen dreier seg om barns opplevelser i krig, og hvordan skolen kan ivareta og bidra til læring for barn som har opplevd livstruende hendelser i krig. Problemstillingen og tema blir belyst av eldre informanter som var barn under 2.verdenskrig. Som teoretisk fundament presenteres teori om traumer og utvikling av PTSD. Videre trekkes det inn teori om regulering, selvregulering og indre ... -
Lidenskap, selvbestemmelse, motivasjon, vitalitet og prestasjonsnivå i fotball
(Master thesis; Mastergradsoppgave, 2019-05-14)Studiet baseres på 120 fotballspillere på bredde og elitenivå som har besvart spørreskjemaer angående idrettpsykologi i fotball. Hensikten med studiet er å finne ut hvordan psykologiske egenskaper som lidenskap, selvbestemmelse, motivasjon og vitalitet korrelerer med hverandre. Studiet ser også nærmere på forskjeller innenfor idrettpsykologi med tanke på kjønn og nivåforskjeller. Funnene fra studiet ... -
Vi vil, men får vi det til? En kvalitativ studie av skoleeiers forståelse av sin oppgave med forankring og implementering av fagfornyelsen fram mot 2020
(Master thesis; Mastergradsoppgave, 2019-05-14)Ledelse er en viktig faktor i alt utviklingsarbeid, og når skoleutvikling er tema, er ledelse ofte knyttet til skoleleders betydning. Med utgangspunkt i at det fram mot 2020 skal forankres og implementeres nye fagplaner i skolene, har jeg valgt å forske på skoleeieres rolle i dette arbeidet. Evalueringer av Kunnskapsløftet viser at det var variasjon i hvor stor grad skoleeiere lyktes med ... -
Endringer av samvær etter omsorgsovertakelse. En studie av barneverntjenestens vurderinger av endringer i samværsomfang mellom barn og biologiske foreldre
(Master thesis; Mastergradsoppgave, 2018-05-14)Bakgrunn: Formålet med denne studien var å undersøke hva ansatte i barneverntjenesten vektlegger når de vurderer endringer i samvær mellom barn og foreldre etter omsorgsovertakelse. Etter å ha valgt ut noen faktorer som er sentrale innenfor nyere barnevernlitteratur ble det undersøkt om faktorer som (i) reaksjoner hos barnet før under eller etter samvær, (ii) barns medvirkning, (iii) de ansattes ... -
Investigating population genomic structure of salmon lice (Lepeophtheirus salmonis) in northern Norway
(Master thesis; Mastergradsoppgave, 2019-05-14)Salmon louse (Lepeophtheirus salmonis) is a parasitic copepod that causes significant damage to Atlantic salmon (Salmo salar) and incurs significant costs to the salmonid aquaculture industry. In Norway, the industry has been coping with salmon lice issues with various methods such as chemical treatments, but it has resulted in an acquisition of resistance in salmon lice towards the existing delousing ... -
Computational Investigation on the Photophysical Properties of Halogenated Tetraphenyl BODIPY
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-07)The electronic structure, transition probabilities, and corresponding quantum yields of fluorescence in a family of dihalogen-tetraphenyl-aza-BODIPY were calculated at the Time-Dependent Density Functional and post-Hartree–Fock levels of theory. Excellent agreement between theoretical and experimental spectral-luminescent data was achieved with the HSE06 functional and the 6-311G* basis set. Because ... -
The challenges of understanding the biogeography of commercially important crustacean species of the Southwestern Indian Ocean — Separating what we know from what we think we know.
(Doctoral thesis; Doktorgradsavhandling, 2020-05-25)Demersal trawl fisheries play an important role in providing income and protein to the people of the Southwestern Indian Ocean (SWIO). These fisheries are very destructive to the habitats in which they operate and have an impact on the associated biodiversity. Three crustacean species, knife prawn (<i>Haliporoides triarthrus</i>), African langoustine (<i>Metanephrops mozambicus</i>) and pink geryon ... -
Structurally controlled rock slope deformation in northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-11)Gravitational forcing of oversteepened rock mass leads to progressive failure, including rupture, creeping, sliding and eventual avalanching of the unstable mass. As the point of rupture initiation typically follows pre-existing structural discontinuities within the rock mass, understanding the structural setting of slopes is necessary for an accurate characterisation of the hazards and estimation ... -
SOME NEW REFINEMENTS OF HARDY-TYPE INEQUALITIES
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-11)We obtain some further refinements of Hardy-type inequalities via superqudraticity technique. Our results both unify and further generalize several results on refinements of Hardy-type inequalities in the literature. -
Nurses’ experiences of ICU diaries following implementation of national recommendations for diaries in intensive care units: A quality improvement project
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)<i>Objectives</i> - To evaluate critical care nurses’ experiences of ICU diaries following the implementation of national recommendations for the use of diaries for critically ill patients.<p><p> <i>Design</i> - A quality improvement project describing the development and implementation of national recommendations (2011), as well as the assessment of the use of diaries in intensive care nursing ... -
Da skjønte jeg at nå smeller det snart: Voksne som opplevde vold i barndommen ser tilbake
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-19)Denne artikkelen undersøker hvordan voksne ser tilbake på sine opplevelser med å håndtere vold som de ble utsatt for av sine omsorgspersoner i oppveksten. Artikkelen bygger på kvalitative intervjuer med syv voksne i alderen 18 til 60 år som alle har vokst opp i hjem der en av omsorgspersonene gjentatte ganger har utøvd vold mot dem og andre i familien. Narrativ teori og sosiokulturell teori er ... -
A novel ECG-biomarker for cardiac arrest during hypothermia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-10)<i>Background</i> - Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Main body</i> - Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG ... -
Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-24)Red spherule cells (RSCs) are considered one of the prime immune cells of sea urchins, but their detailed biological role during immune responses is not well elucidated. Lack of pure populations accounts for one of the major challenges of studying these cells. In this study, we have demonstrated that live RSCs exhibit strong, multi-colour autofluorescence distinct from other coelomocytes, and with ... -
De lojale offiserer, en studie av deres reaksjoner på multiple endringer.
(Master thesis; Mastergradsoppgave, 2017-05-13)Formålet med denne utredningen er å øke forståelsen for reaksjonen til den endringsvante militært ansatte i Forsvaret. Utredningen er en singelcase studie av en hæravdeling Forsvaret. Metodisk tilnærming i oppgaven er kvalitative intervjuer, dataen til analysen presenteres og drøftes i samme kapittel. Samtlige intervju er transkribert samt at relevante funn har blitt analysert og tolket opp mot ... -
Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study
(Master thesis; Mastergradsoppgave, 2015-05-13)The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ... -
Quantitative Phosphoprotein Analysis in Adipose Tissue
(Master thesis; Mastergradsoppgave, 2016-05-13)Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ... -
Molecular aspects of high-risk neuroblastoma and novel therapeutic opportunities
(Doctoral thesis; Doktorgradsavhandling, 2020-05-29)Neuroblastoma is a highly heterogenous cancer of childhood. High-risk disease has a poor prognosis with survival around 50% and cured patients suffer treatment related late effects. Better therapy is needed. Increased knowledge of the molecular biology of high-risk neuroblastomas is essential to devise new treatments. High-risk neuroblastomas are frequently MYCN-amplified (MNA). MNA is correlated ... -
MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ... -
Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)<p><i>Background:</i> In recent years, evidence has accumulated indicating that both normal and cancer cells communicate via the release and delivery of macromolecules packed into extracellular membrane vesicles. <p><i>Materials and Methods:</i> We isolated nano-sized extracellular vesicles from MYCN-amplified neuroblastoma cell lines using ultracentrifugation and exosome precipitation (Exoquick) ...
