Viser treff 19301-19320 av 36350

    • ABCC9-related intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9 

      Smeland, Marie Falkenberg; McClenaghan, Conor; Roessler, Helen I.; Savelberg, Sanne; Hansen, Geir Åsmund Myge; Hjellnes, Helene; Arntzen, Kjell Arne; Müller, Kai Ivar; Dybesland, Andreas R.; Harter, Theresa; Sala-Rabanal, Monica; Emfinger, Chris H.; Huang, Yan; Singareddy, Soma S.; Gunn, Jamie; Wozniak, David F.; Kovacs, Attila; Massink, Maarten; Tessadori, Federico; Kamel, Sarah M.; Bakkers, Jeroen; Remedi, Maria S.; Van Ghelue, Marijke; Nichols, Colin G.; van Haaften, Gijs (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-01)
      Mutations in genes encoding K<sub>ATP</sub> channel subunits have been reported for pancreatic disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families with a consistent phenotype of mild intellectual disability, similar facies, myopathy, and cerebral white matter hyperintensities, with cardiac systolic dysfunction present in the two oldest patients. Patients are ...
    • Homogenization of biased convolution type operators 

      Piatnitski, Andrey; Zhizhina, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
      This paper deals with homogenization of parabolic problems for integral convolution type operators with a non-symmetric jump kernel in a periodic elliptic medium. It is shown that the homogenization result holds in moving coordinates. We determine the corresponding effective velocity and prove that the limit operator is a second order parabolic operator with constant coefficients. We also consider ...
    • Responsible research and innovation: a systematic review of the literature and its applications to regional studies 

      Thapa, Rajan Kumar; Iakovleva, Tatiana Aleksandrovna; Foss, Lene (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-14)
      While innovation should be about socioeconomic transformation of society, concerns have been raised about its negative externalities including growing disparities within and between regions. Arguably, Responsible Research and Innovation (RRI) offers a potential solution to address these concerns. However, in theory, its conceptualization and operationalization remain ambiguous. Further, in practice, ...
    • A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes 

      Dusart, Philip James; Hallström, Björn M.; Renne, Thomas; Odeberg, Jacob Olof; Uhlén, Mathias; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex ...
    • Effects of interval training on quality of life and cardiometabolic risk markers in older adults: a randomized controlled trial 

      Ballin, Marcel; Lundberg, Emmy; Sörlén, Niklas; Nordström, Peter; Hult, Andreas; Nordström, Anna Hava (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
      <i>Purpose</i>: To explore the effects of 10 weeks of progressive vigorous interval training as a single intervention on health-related quality of life (HRQoL) and cardiometabolic risk markers in centrally obese 70-year-old individuals.<p><p> <i>Participants and methods</i>: A randomized controlled trial (ClinicalTrials.gov registration no. NCT03450655) including seventy-seven community-dwelling ...
    • Unexpected Molecular Structure of a Putative Rhenium-Dioxo-Benzocarbaporphyrin Complex. Implications for the Highest Transition Metal Valence in a Porphyrin-Type Ligand Environment 

      Alemayehu, Abraham; Vazquez-Lima, Hugo; Teat, Simon J.; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-18)
      A combination of quantum chemical calculations and synthetic studies was used to address the possibility of very high (>6) valence states of transition metals in porphyrin‐type complexes. With corrole as a supporting ligand, DFT calculations ruled out Re(VII) and Ir(VII) dioxo complexes as stable species. Attempted rhenium insertion into benzocarbaporphyrin (BCP) ligands on the other hand led to two ...
    • Exploring future C++ features within a geometric modeling context 

      Bratlie, Jostein; Dalmo, Rune (Conference object; Konferansebidrag, 2019-11)
      The development of the C++ programming language and its standard library has undergone a renaissance since the introduction of the C++11 standard, making the language more relevant than ever, through modern features, simplification and expansion of the standard library. Comparing past and future feature sets (C++17, C++20, ...) similar to comparing different programming languages. In this article ...
    • Ørnfløya 1. En pionertidslokalitet fra tidlig eldre steinalder på yttersida av Kvaløya i Troms 

      Blankholm, Hans Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
      During the past couple of decades both research projects and rescue excavations have contributed considerably to our understanding of the early Older Stone Age pioneer settlement along the entire Norwegian coast. However, understanding of the pioneers along the coast between northern Nordland and Finnmark counties is still rather limited. Excavations have largely taken place on sites within the ...
    • The Role of the Three Rs in Improving the Planning and Reproducibility of Animal Experiments 

      Smith, Adrian John; Lilley, Elliot (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-14)
      Efforts to improve the design of animal studies have tended to focus on the more mathematical aspects, such as randomization, blocking and statistical analysis. There are, however, many other factors that affect the data from preclinical studies. To improve validity, scientists must collaborate closely with the animal facility involved as soon as the decision to use animals has been made. Such ...
    • Limit behaviour of diffusion in high-contrast periodic media and related Markov semigroups 

      Piatnitski, Andrey; Pirogov, S; Zhizhina, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      The goal of the paper is to describe the large time behaviour of a symmetric diffusion in a high-contrast periodic environment and to characterize the limit process under the diffusive scaling. We consider separately the C0 and the L2 settings.
    • Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects 

      Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R; Kvitting, John Peder Escobar; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom Eirik; Nilsson, Per; Louwe, Maria Cornelia; Ranheim, Trine (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-10)
      <i>Objective</i> - The aetiology of thoracic aortic aneurysm (TAA) is largely unknown, but inflammation is likely to play a central role in the pathogenesis. In this present study, we aim to investigate the complement receptors in TAA.<p> <p><i>Methods</i> - Aortic tissue and blood from 31 patients with non-syndromic TAA undergoing thoracic aortic repair surgery were collected. Aortic tissue and ...
    • Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop 

      Russell, Ashley E.; Sneider, Alexandra; Witwer, Kenneth W.; Bergese, Paolo; Bhattacharyya, Suvendra N.; Cocks, Alexander; Cocucci, Emanuele; Erdbrügger, Uta; Falcón-Pérez, Juan M.; Freeman, David W.; Gallagher, Thomas M.; Hu, Shuaishuai; Huang, Yiyao; Jay, Steven M.; Kano, Shin-ichi; Lavieu, Gregory; Leszczynska, Aleksandra; Llorente Martinez, Alicia; Lu, Quan; Mahairaki, Vasiliki; Muth, Dillon C.; Hooten, Nicole Noren; Ostrowski, Matias; Prada, Ilaria; Sahoo, Susmita; Schøyen, Tine Hiorth; Sheng, Lifu; Tesch, Deanna; Van Niel, Guillaume; Vandenbroucke, Roosmarijn E.; Verweij, Frederik J.; Villar, Ana V.; Wauben, Marca; Wehman, Ann M.; Yin, Hang; Carter, David Raul Francisco; Vader, Pieter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-08)
      Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes and EVs, the International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 in Baltimore, Maryland, ...
    • Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study 

      Voomolen, DC; Haagsma, JA; Polinder, Suzanne; Maas, AIR; Steyerberg, Ewout W; Vulekovic, Peter; Sewalt, CA; Gravesteijn, BY; Covic, Amra; Andelic, Nada; Plass, AM; von Steinbüchel, Nicole; Vik, Anne; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin Kordasti; Helseth, Eirik; Skandsen, Toril; Røise, Olav; Håberg, Asta; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-08)
      Abstract The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) at three and six months post-injury. Patients were included through the prospective cohort study: Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI). Patients ...
    • Outsider Art? Herleik Kristiansens kunstneriske prosesser 

      Federhofer, Marie-Theres; Høvik, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-09)
      Denne artikkelen utfordrer anvendeligheten av konseptet <i>Outsider Art</i> gjennom en analyse av Herleik Kristiansens kunstneriske prosesser. Kristiansen er psykisk utviklingshemmet, og i perioden 1963–93 var han beboer ved institusjonen Trastad Gård. Prosessene som diskuteres er: Kristiansens utvikling som kunstner, hans særegne måte å skape kunst på og til sist transformasjonen av natur til kultur ...
    • CSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions 

      Moreno, Aitor; Hansen, Kine; Isaksson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      A new pulse program development, a chemical shift selective filtration clean in-phase HSQMBC (CSSF-CLIP-HSQMBC), is presented for the user-friendly measurement of long-range heteronuclear coupling constants in severely crowded spectral regions. The introduction of the chemical shift selective filter makes the experiment extremely efficient at resolving overlapped multiplets and produces a clean ...
    • Electric and magnetic senses in marine animals, and potential behavioral effects of electromagnetic surveys 

      Nyqvist, Daniel; Durif, Caroline; Johnsen, Magnar Gullikstad; de Jong, Karen; Forland, Tonje Nesse; Sivle, Lise Doksæter (Journal article; Tidsskriftartikkel, 2020-01-24)
      Electromagnetic surveys generate electromagnetic fields to map petroleum deposits under the seabed with unknown consequences for marine animals. The electric and magnetic fields induced by electromagnetic surveys can be detected by many marine animals, and the generated fields may potentially affect the behavior of perceptive animals. Animals using magnetic cues for migration or local orientation, ...
    • Nordic Word Order Database: Motivations, methods, material and infrastructure 

      Lundquist, Bjørn; Larsson, Ida; Westendorp, Maud; Tengesdal, Eirik; Nøklestad, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-19)
      In this article, we present the Nordic Word Order Database (NWD), with a focus on the rationale behind it, the methods used in data elicitation, data analysis and the empirical scope of the database. NWD is an online database with a user-friendly search interface, hosted by The Text Laboratory at the University of Oslo, launched in April 2019 (https://tekstlab.uio.no/nwd). It contains elicited ...
    • The Costly and Demanding: Exploring Solution-based Othering of Non-European Immigrants in Norwegian Policy Recommendations 

      Andreasen, Søren Mosgaard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)
      This article examines the Norwegian scholarly report titled <i>NOU 2017:2—Integration and Trust: Long-Term Consequences of High Immigration</i> (English translation; chapter 1.1) to unpack how ‘non-European immigrants’ are constructed as an economic and social challenge for the welfare state. Principles from discourse theory (DT) and the conceptual framework of othering are applied to discuss how ...
    • Positional Differences in Peak- and Accumulated- Training Load Relative to Match Load in Elite Football 

      Baptista, Ivan; Johansen, Dag; Figueiredo, Pedro; Rebelo, Antonio; Pettersen, Svein Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-23)
      Quantification of training and match load is an important method to personalize the training stimulus’ prescription to players according to their match demands. The present study used time-motion analysis and triaxial-accelerometer to quantify and compare: a) The most demanding passages of play in training sessions and matches (5-min peaks); b) and the accumulated load of typical microcycles and ...
    • Samisk nasjonaldag i skolen: Mellom feiring og markering 

      Olsen, Torjer Andreas; Sollid, Hilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      Den samiske nasjonaldagen 6. februar blei innstifta i 1992 til minne om det første samiske landsmøtet eller folkemøtet i Trondheim i 1917. I dag er dagen flere steder i landet blitt en viktig dag for å lage en markering og ha en anledning til å ta opp et samisk innhold i undervisninga. Vi går i denne artikkelen inn på den samiske nasjonaldagen som ritual på skolen. Teoretisk sett ser vi til ...