Gesetz und Gesetzlichkeit spielen in Kants kritischer Philosophie eine hervorragende Rolle. Denn die menschliche Vernunft ist für Kant ein Vermögen der Gesetzgebung. Der Nachweis allgemein gültiger Vernunftgesetze, in denen die Menschen in all ihrer Verschiedenheit vereint sind, ist deshalb auch für Kants Ethik zentral. Er entwickelt eine Gesetzesethik. Paulus dagegen hat eine wirkmächtige Tradition ...

Simone de Beauvoir og Jean Améry har skrevet avgjørende verk innen aldringens fenomenologi som avdekker sentrale sider ved den aldrendes erfaring av kropp og tid. Begge mener at det innskrenkede handlingsrommet og den forkortede fremtidshorisonten som alderdommen medfører, truer livets meningsfullhet. Dette hviler imidlertid på premisset om at det meningsfulle livet utfolder seg som ungdommelighet, ...

Introduction: Educational inequality in multiple health behaviors is rarely monitored using data from the same individuals as they age. The aim of this study is to research changes in relative educational inequality in multiple variables related to health behavior (smoking, physical activity, alcohol intake, and body mass index), separately and collectively (healthy lifestyle), among middle-aged adults ...

Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA ...

Dementia disease research encompasses diverse data modalities, including advanced imaging, deep phenotyping, and multi-omics analysis. However, integrating these disparate data sources has historically posed a significant challenge, obstructing the unification and comprehensive analysis of collected information. In recent years, knowledge graphs have emerged as a powerful tool to address such ...

This paper examines infant mortality amongst newborns in Trondheim city, 1830–1907, working specifically with individual level cause of death data. Findings show that infant mortality in the city started to drop from 1895, primarily as a result of a decline in post-neonatal mortality. At the start of the decline air-borne diseases accounted for nearly half of the deaths, and water-food borne for ...

Ice accretion on railway overhead contact wires/conductors can cause various critical operational and safety issues such as overloading, arc formation, mass imbalance, and wire galloping. The focus of this multiphase numerical study is to understand and analyze the ice accretion physics on railway overhead powerline conductors at various operating conditions. In this regard, two different ...

The global prevalence of infections caused by extended-spectrum βlactamase-producing Enterobacterales (ESBL-E) is increasing, and for Escherichia coli, observations indicate that this is partly driven by community-onset cases. The ESBL-E population structure in the community is scarcely described, and data on risk factors for carriage are conflicting. Here, we report the prevalence and population ...

Background Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of immune dysregulation has been indicated, and the efects of psychopharmacological agents vary. We investigated if impul‑ sivity was associated with circulating immune marker levels and ...

The retrofitting of buildings for improved energy efficiency has been recognized as crucial for achieving climate mitigation goals in Bosnia and Herzegovina (B&H). However, performing multi-objective optimizations for retrofitting existing buildings poses challenges, as it requires balancing conflicting objectives such as retrofit costs, energy savings, and CO₂ reduction. To tackle ...