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Contrasting the phospholipid profiles of two neoplastic cell lines reveal a high PC:PE ratio for SH-SY5Y cells relative to A431 cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)Lipids have been implicated in Parkinson's Disease (PD). We therefore studied the lipid profile of the neuroblastoma SH-SY5Y cell line, which is used extensively in PD research and compared it to that of the A431 epithelial cancer cell line. We have isolated whole cell extracts (WC) and plasma membrane (PM) fractions of both cell lines. The isolates were analyzed with 31P NMR. We observed a significant ... -
Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)The physical stability of peptide-based drugs is of great interest to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs of which are frequently used in the treatment of type 2 diabetes. We investigated the physical stability of GLP-1 and its C-terminal amide derivative, GLP-1-Am, both of which aggregate into amyloid fibrils. While off-pathway ... -
Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)Objective: To compare administration of the glucagon-like peptide-1 (GLP-1) analogue, exenatide, versus dietary supplementation with the omega-3 fatty acid-rich Calanus oil on obesity-induced alterations in mitochondrial respiration.<p> <p>Methods: Six-week-old female C57BL/6JOlaHSD mice were given high fat diet (HFD, 45% energy from fat) for 12 weeks to induce obesity. Thereafter, they were ... -
The capability of square-meshes and fixed-shape meshes to control codend size selection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-11)Trawl codends are commonly made of diamond-mesh netting. However, diamond-mesh codends vary in mesh geometry along its length and during fishing due to catch build up. This introduces variability in the size selection process. This phenomenon compromises the rationality of regulating exploitation patterns in trawl fisheries through adjustments in codend mesh size. One technical solution often ... -
Sustained year-round oceanographic measurements from Rothera Research Station, Antarctica, 1997–2017
(Journal article; Tidsskriftartikkel, 2023-05-10)Oceanographic changes adjacent to Antarctica have global climatic and ecological impacts. However, this is the most challenging place in the world to obtain marine data due to its remoteness and inhospitable nature, especially in winter. Here, we present more than 2000 Conductivity-Temperature-Depth (CTD) profiles and associated water sample data collected with (almost uniquely) full year-round ... -
Extreme Horizontal Wind Perturbations in the Mesosphere and Lower Thermosphere Over South America Associated With the 2022 Hunga Eruption
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-13)On 15 January 2022, the Hunga volcano produced a massive explosion that generated perturbations in the entire atmosphere. Nonetheless, signatures in the mesosphere and lower thermosphere (MLT) have been challenging to identify. We report MLT horizontal wind perturbations using three multistatic specular meteor radars on the west side of South America (spanning more than 3,000 km). The most ... -
Timber as a Marine Resource: Exploitation of Arctic Driftwood in the North Atlantic
(Journal article; Tidsskriftartikkel, 2023-03-07)The North Atlantic islands of the Faroe Islands, Iceland and Greenland have always been relatively poor in terms of native timber resources, due to their cold climate and exposed topography. Nevertheless, timber was vital to the material culture of the Norse settlers of these islands, and driftwood often met this need. As in subarctic Norway, where trees are also scarce, driftwood use and ownership ... -
Time-varying market efficiency of safe-haven assets
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)This study investigates the hedge and safe-haven possibilities with bitcoin, gold and crude oil in different equity markets in the presence of time-varying market inefficiency. Our results indicate that periods of market inefficiency for the Bitcoin, gold and crude oil price positively influence their function as a hedge asset for the equity markets of Japan, China, the US, Europe and emerging ... -
Metabolic profile in women with bulimia nervosa or binge-eating disorder before and after treatment: secondary analysis from the randomized PED-t trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)Purpose: Chaotic eating and purging behavior pose a risk to the metabolic health of women with bulimia nervosa (BN) and binge-eating disorder (BED). This study reports on one-year changes in blood markers of metabolic health and thyroid hormones in women with BN or BED attending two different treatments. Methods: These are secondary analyses from a randomized controlled trial of 16-week group ... -
A pilot study of implementation of endoscopic sleeve gastroplasty (ESG) in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)Background and aim - Bariatric surgery is the most effective treatment for obesity but is invasive and associated with serious complications. Endoscopic sleeve gastroplasty (ESG) is a less invasive weight loss procedure to reduce the stomach volume by full-thickness sutures. ESG has been adopted in many countries, but implementation at Scandinavian centres has not yet been documented. We performed ... -
Web-Based Interventions Reduced Dental Anxiety among Adults in Lithuania and Norway: A Pilot Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-14)Dental anxiety (DA) is a prevalent public health issue. However, there is a lack of self-administered DA interventions. The aim of this study was to evaluate the short-term effects of web-based interventions aiming to reduce DA in adults in two European countries. A pretest posttest design was used. Tailor-made websites were developed in Lithuania and Norway. Volunteers who self-reported DA were ... -
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)Background: The gut microbiota in patients with chronic heart failure (HF) is characterized by low bacterial diversity and reduced ability to synthesize beneficial metabolites. These changes may facilitate leakage of whole bacteria or bacterial products from the gut into the bloodstream, which may activate the innate immune system and contribute to the low-grade inflammation seen in HF. In this ... -
MRNG: Accessing Cosmic Radiation as an Entropy Source for a Non-Deterministic Random Number Generator
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-26)Privacy and security require not only strong algorithms but also reliable and readily available sources of randomness. To tackle this problem, one of the causes of single-event upsets is the utilization of a non-deterministic entropy source, specifically ultra-high energy cosmic rays. An adapted prototype based on existing muon detection technology was used as the methodology during the experiment ... -
Preferences for an eHealth tool to support physical activity and exercise training in COPD: a qualitative study from the viewpoint of prospective users
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-13)Background Despite well-known positive efects of pulmonary rehabilitation, access is limited. New strategies to improve access are advocated, including the use of eHealth tools.<p> <p>Objectives The aim of this study was to explore prospective users’ preferences for an eHealth tool to support the selfmanagement of physical activity and exercise training in COPD. <p>Methods A qualitative research ... -
Biochemical and structural characterisation of a family GH5 cellulase from endosymbiont of shipworm P. megotara
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-04)Background Cellulases play a key role in the enzymatic conversion of plant cell-wall polysaccharides into simple and economically relevant sugars. Thus, the discovery of novel cellulases from exotic biological niches is of great interest as they may present properties that are valuable in the biorefning of lignocellulosic biomass. Results We have characterized a glycoside hydrolase 5 (GH5) domain ... -
Investigation of wireless electrification for a reconfigurable manufacturing cell
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)Reconfigurable manufacturing systems (RMS) with a rearrangeable structure can quickly adjust their productivity to meet the dynamic market changes and the demand for high-variety products. Industry 4.0 technologies have enhanced the RMS flexibility and made the automation of the reconfiguration of the manufacturing system possible. As an Industry 4.0 technology, wireless power transfer (WPT) can ... -
Sea Ice Remote Sensing—Recent Developments in Methods and Climate Data Sets
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-03)Sea ice monitoring by polar orbiting satellites has been developed over more than four decades and is today one of the most well-established applications of space observations. This article gives an overview of data product development from the first sensors to the state-of-the-art regarding retrieval methods, new products and operational data sets serving climate monitoring as well as daily operational ... -
Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-25)Due to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a good prognosis, resembles to the lytic phase of progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease caused by JC polyomavirus (JCPyV). Therefore, the presence of JCPyV DNA was examined in an 11-year-old child with xanthoastrocytoma, ... -
Association between Alcohol Consumption and Body Composition in Russian Adults and Patients Treated for Alcohol-Related Disorders: The Know Your Heart Cross-Sectional Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-07)There is conflicting evidence about the association between alcohol consumption and body composition (BC). We aimed to investigate this association in Russian adults. The study population included 2357 residents of Arkhangelsk aged 35–69 years, and 272 in-patients treated for alcohol problems (narcological patients) who participated in the Know Your Heart (KYH) cross-sectional study in 2015–2017. ... -
Botulinum Toxin A in the treatment of frostbite sequelae–results from a blinded, early-phase, comparative trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-15)Introduction: Freezing Cold Injuries (FCI) have been associated with long-term sequelae including vasospasm. The aims of the pilot study are to explore the research methodology and investigate the tolerability and safety of treatment with Botulinum Toxin-A (BTX-A) in FCI Sequelae. Methodology: This pilot study tests the logistics, the treatment setting and the follow-up procedure in an early-phase, ...