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The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria ... -
Kausale design – Et gjennombrudd i samfunnsfagene eller keiserens nye klær?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-03)Statistiske metoder som regresjonsanalyse og kausale design basert på naturlige eksperi-menter har etter hvert blitt hyllevare innen de fleste fag som behandler store datamengder,ikke minst innen epidemiologi, meteorologi og klimavitenskap.1 Et eksempel er prinsipalkomponentanalyse (PCA), som brukes til å finne karakteristiske mønstre i geofysiske felt.Mønstrene, eller prinsipalkomponentene, ... -
Skaper MSC mer bærekraftige fiskerier?
(Master thesis; Mastergradsoppgave, 2022-09-01)I løpet av 2021 mistet Norge bærekraftsertifiseringen MSC for hyse og torsk fanget innenfor 12 nautiske mil. Temaet for oppgaven er å se på hvilke effekter dette bortfallet har hatt for alle ledd i verdikjeden fra fisker til eksportør. Det ble tatt utgangspunkt i følgende problemstilling: «Hva er konsekvensene av bortfall av MSC-sertifikat for torsk fisket innenfor 12 nautiske mil?» Ut i fra ... -
Naphthoquinone pigments from the green sea urchin, Strongylocentrotus droebachiensis
(Master thesis; Mastergradsoppgave, 2021-02-08)Spinochromes are part of a subgroups of quinones called naphthoquinones. These molecules have a series of bioactivity making them a promising target for marine researchers all over the world. Sulphated spinochromes was recently identified, but their structure or bioactivity is yet to be elucidated. In this project, an attempt to extract these sulphated spinochromes from red spherule cells are made. ... -
Quaternary and Neogene Reservoirs of the Norwegian Continental Shelf and the Faroe-Shetland Basin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-01)Glaciogenic reservoirs host important hydrocarbon resources across the globe. Examples such as the Peon and Aviat discoveries in the North Sea show that Quaternary and Neogene reservoirs can be prospective in the region. In this study, we interpret 2D and 3D reflection seismic data combined with borehole information to document unconventional play models from the shallow subsurface of the Norwegian ... -
Stability and trust in federations with ethnic territories and a secession clause - Challenges and opportunities for Ethiopia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-24)<p>How might Ethiopia maintain its federal structure and its territory? ‘Constitutional contestation’ in Ethiopia is fuelled by two factors: regions and political parties follow ethnic line; and the Ethiopian Constitution has a secession clause. <p>A central challenge is to secure sufficient political trust. The public must be assured that authorities and individuals across regional borders generally ... -
Obesity-related venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2023-02-22)Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and multicausal disease. Obesity is a major and likely causal risk factor for VTE. However, to what extent obesity contributes to VTE risk in the general population and the mechanism of obesity-related VTE remain poorly understood. The overall aim of this thesis was (i) to ... -
Hormonal IUD is the major hormonal contraceptive method used among women aged 40 –49 years: Data from the 2015 –16 Tromsø Study, Norw
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)Objective - This study aims to investigate hormonal contraceptive (HC) use and user characteristics in women aged 40–49 years in Norway, as little is known on use of HCs in this age segment.<p> <p>Material and methods - This prevalence study included 2296 women aged 40–49 years who participated in the 2015–16 Tromsø Study, which collected self-reported sociodemographic information and data from ... -
Atlantic salmon immune responses after infection with intracellular pathogens
(Doctoral thesis; Doktorgradsavhandling, 2023-02-21)We focused on the responses of two arms of the Atlantic salmon immune system against intracellular pathogens: the antibody (Ab) production by B cells after challenge with the facultative intracellular bacterium <i>Pisciricketsia salmonis</i> and the interferon (IFN) responses in a salmonid cell line against salmon alphavirus (SAV), infectious necrotic pancreas virus (IPNV), and <i>P. salmonis</i>. ... -
Observer agreement of imaging measurements used for evaluation of dentofacial deformity in juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-02)Objectives: To examine the precision of imaging measures commonly used to assess mandibular morphology in children and adolescents with juvenile idiopathic arthritis (JIA). Secondly, to compare cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in the measurement of condylar height.<p> <p>Methods: Those included were children diagnosed with JIA during 2015–18 who had had ... -
Lederskjønnets utfordringer i kommunalt barnevern: Om spenninger mellom faglig skjønn og lederskjønn
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-11)I den pågående barnevernreformen sees ledelse som en av nøklene til økt kvalitet i barnevernet. I denne artikkelen utforsker vi hvordan barnevernlederne håndterer spenninger mellom faglig skjønn og lederskjønn. Det drøftes hvilke fallgruver som kan oppstå ved bruk av et faglig kollektivt skjønn som grunnlag for lederbeslutninger, samt hvordan et kollektivt faglig skjønn kan fungere som en støtte for ... -
Better together? How evolution of co-branding alliance affects performance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-24)<p><b> Purpose</b> The purpose of this study is to examine role stress over the course of an alliance between supply chains. This study examines ambiguity as antecedent to multiple organisational outcomes. <p><b> Design/methodology/approach</b> This study subsequently uses a time series design that uses a close replication of the authors’ initial study. The design affords the opportunity ... -
Russian feminitives: what can corpus data tell us?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-22)Recent years have seen considerable debate concerning Russian feminitives, i.e. derived formations that designate female professionals, such as advokatka, advokatša, advokatessa, ženščina-advokat or advokat-ženščina that all refer to female lawyers. In this article, we investigate the use of feminitives based on data from the Araneum Russicum Maximum corpus and the Russian National Corpus. It is ... -
Extraction from finite adjunct clauses: an investigation of relative clause dependencies in Norwegian
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Recent experiments have confirmed earlier informal evidence that finite adjuncts are not islands categorically. Specifically, it has been shown that adjuncts are not necessarily islands for all dependency types (Sprouse et al. 2016), and that the island status of an adjunct depends on the type of the adjunct clause in question (Kush et al. 2019; Müller 2019; Bondevik et al. 2021; Nyvad et al. ... -
UA and pinch point temperature difference modeling — Finding the best heat exchanger schemes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-28)Process models using simplified heat exchanger (HE) models are often analyzed using methods based on derivatives or optimization procedures, where even small numerical errors can cause algorithms to fail. This article explores the use of numerical approximations for calculating pinch temperature and UA-value, including novel high-order polynomial methods using equidistant and Chebyshev grids. The ... -
Progressive cities: Urban–rural polarisation of social values and economic development around the world
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)In contrast to the conservative values of rural populations, cities are often seen as bulwarks of more tolerant, liberal and progressive values. This urban–rural divide in values has become one of the major fault lines in Western democracies, underpinning major political events of the last decade, not least the election of Donald Trump. Yet, beyond a small number of countries, there is little ... -
Association of internalised homonegativity with partner notifcation after diagnosis of syphilis or gonorrhoea among men having sex with men in 49 countries across four continents
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)Background: Partner notifcation (PN) after a sexually transmitted infection (STI) diagnosis is being promoted as a means to interrupt transmission chains. We investigated whether Internalised Homonegativity (IH) is associated with PN among men having sex with men (MSM).<p> <p>Methods: PN, defned as notifying at least one partner after diagnosis of syphilis and gonorrhoea, was queried in two ... -
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual ... -
Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-08)Background Normal breast tissue is utilized in tissue-based studies of breast carcinogenesis. While gene expression in breast tumor tissue is well explored, our knowledge of transcriptomic signatures in normal breast tissue is still incomplete. The aim of this study was to investigate variability of gene expression in a large sample of normal breast tissue biopsies, according to breast cancer related ... -
On the spectrum of convolution operator with a potential
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)This paper focuses on the spectral properties of a bounded self-adjoint operator in <b><i>L</i><sub>2</sub></i></b>(R<sup>d</sup>) being the sum of a convolution operator with an integrable convolution kernel and an operator of multiplication by a continuous potential converging to zero at infinity. We study both the essential and the discrete spectra of this operator. It is shown that the essential ...