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dc.contributor.authorFlote, Vidar Gordon
dc.contributor.authorVettukattil, Muhammad Riyas
dc.contributor.authorBathen, Tone Frost
dc.contributor.authorEgeland, Thore
dc.contributor.authorMcTiernan, Anne
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorHusøy, Anders
dc.contributor.authorFinstad, Sissi Espetvedt
dc.contributor.authorLømo, Jon
dc.contributor.authorGarred, Øystein
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorWist, Erik
dc.contributor.authorThune, Inger
dc.date.accessioned2017-01-10T08:56:40Z
dc.date.available2017-01-10T08:56:40Z
dc.date.issued2016-11-08
dc.description.abstract<b>Background:</b> High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions is associated with breast tumor characteristics remains unclear.<br> <b>Methods:</b> Among 56 women with newly diagnosed invasive breast cancer stage I/II, aged 35–75 years, pre-surgery overnight fasting serum concentrations of lipids were assessed, and body mass index (BMI) was measured. All breast tumors were immunohistochemically examined in the surgical specimen. Serum metabolomics of lipoprotein subfractions and their contents of cholesterol, free cholesterol, phospholipids, apolipoprotein-A1 and apolipoprotein-A2, were assessed using nuclear magnetic resonance. Principal component analysis, partial least square analysis, and uni- and multivariable linear regression models were used to study whether lipoprotein subfractions were associated with breast cancer tumor characteristics.<br> <b>Results:</b> The breast cancer patients had following means: age at diagnosis: 55.1 years; BMI: 25.1 kg/m2 ; total-Cholesterol: 5.74 mmol/L; HDL-Cholesterol: 1.78 mmol/L; Low-Density Lipoprotein (LDL)-Cholesterol: 3.45 mmol/L; triglycerides: 1.18 mmol/L. The mean tumor size was 16.4 mm, and the mean Ki67 hotspot index was 26.5 %. Most (93 %) of the patients had estrogen receptor (ER) positive tumors (≥1 % ER+), and 82 % had progesterone receptor (PgR) positive tumors (≥10 % PgR+). Several HDL subfraction contents were strongly associated with PgR expression: Apolipoprotein-A1 (β 0.46, CI 0.22–0.69, p < 0.001), HDL cholesterol (β 0.95, CI 0.51–1.39, p < 0.001), HDL free cholesterol (β 2.88, CI 1.28–4.48, p = 0.001), HDL phospholipids (β 0.70, CI 0.36–1.04, p < 0.001). Similar results were observed for the subfractions of HDL1-3. We observed inverse associations between HDL phospholipids and Ki67 (β -0.25, p = 0.008), and in particular between HDL1’s contents of cholesterol, phospholipids, apolipoprotein-A1, apolipoprotein-A2 and Ki67. No association was observed between lipoproteins and ER expression.<br> <b>Conclusion:</b> Our findings hypothesize associations between different lipoprotein subfractions, and PgR expression, and Ki 67 % in breast tumors. These findings may have clinical implications, but require confirmation in larger studiesen_US
dc.identifier.citationLipids in Health and Disease 2016, 15(56)en_US
dc.identifier.cristinIDFRIDAID 1368143
dc.identifier.doi10.1186/s12944-016-0225-4
dc.identifier.issn1476-511X
dc.identifier.issn1476-511X
dc.identifier.urihttps://hdl.handle.net/10037/10124
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccessen_US
dc.subjectLipoproteinsen_US
dc.subjectSubfractionsen_US
dc.subjectHDLen_US
dc.subjectBreast canceren_US
dc.subjectTumoren_US
dc.subjectProgesterone receptoren_US
dc.subjectKi67en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.titleLipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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