English
norskGlobal Lung Function Initiative 2012 reference equations for spirometry in the Norwegian Population
Permanent link
https://hdl.handle.net/10037/10206
Date
2016-10-06Type
Journal articleTidsskriftartikkel
Peer reviewed
Abstract
Background: We studied the fit of the Global Lung Function Initiative all-age reference values to
Norwegians, compared them with currently used references (European Community for Steel and Coal
(ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.
Methods: Spirometry data collected in 30,239 subjects (51.7% females) aged 12-90 years in three population-based studies were converted to z-scores. Results: Healthy non-smokers comprised 2,438 adults (57.4% females) aged 20 – 90 and 8,725 (47.7% female) adolescents aged 12-19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median (SD) z-scores were respectively 0.02 (1.03), 0.01 (1.04) and - 0.04 (0.91) for FEV1, FVC and FEV1/FVC in males, and -0.01 (1.02), 0.07 (0.97) and -0.21 (0.82) in females. The ECSC and Zapletal references significantly underestimated FEV1 and FVC. Stricter criteria of obstruction (FEV1/FVC < the GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV1/FVC < 0.7 and > GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a fourfold higher risk for women.
Conclusion: The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV1/FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV1/FVC < 0.7.
Methods: Spirometry data collected in 30,239 subjects (51.7% females) aged 12-90 years in three population-based studies were converted to z-scores. Results: Healthy non-smokers comprised 2,438 adults (57.4% females) aged 20 – 90 and 8,725 (47.7% female) adolescents aged 12-19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median (SD) z-scores were respectively 0.02 (1.03), 0.01 (1.04) and - 0.04 (0.91) for FEV1, FVC and FEV1/FVC in males, and -0.01 (1.02), 0.07 (0.97) and -0.21 (0.82) in females. The ECSC and Zapletal references significantly underestimated FEV1 and FVC. Stricter criteria of obstruction (FEV1/FVC < the GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV1/FVC < 0.7 and > GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a fourfold higher risk for women.
Conclusion: The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV1/FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV1/FVC < 0.7.
Description
This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.
The published version is available at http://dx.doi.org/10.1183/13993003.00443-2016
The published version is available at http://dx.doi.org/10.1183/13993003.00443-2016
Publisher
European Respiratory Society: ERJWiley