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dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorJohannessen, Ane
dc.contributor.authorHolmen, Turid Lingaas
dc.contributor.authorMelbye, Hasse
dc.contributor.authorStanojevic, Sanja
dc.contributor.authorLund, May Brit
dc.contributor.authorMelsom, Morten Nissen
dc.contributor.authorBakke, Per S.
dc.contributor.authorQuanjer, Philip
dc.date.accessioned2017-01-24T11:27:33Z
dc.date.available2017-01-24T11:27:33Z
dc.date.issued2016-10-06
dc.description.abstract<b>Background:</b> We studied the fit of the Global Lung Function Initiative all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.<br> <b>Methods:</b> Spirometry data collected in 30,239 subjects (51.7% females) aged 12-90 years in three population-based studies were converted to z-scores. Results: Healthy non-smokers comprised 2,438 adults (57.4% females) aged 20 – 90 and 8,725 (47.7% female) adolescents aged 12-19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median (SD) z-scores were respectively 0.02 (1.03), 0.01 (1.04) and - 0.04 (0.91) for FEV1, FVC and FEV1/FVC in males, and -0.01 (1.02), 0.07 (0.97) and -0.21 (0.82) in females. The ECSC and Zapletal references significantly underestimated FEV1 and FVC. Stricter criteria of obstruction (FEV1/FVC < the GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV1/FVC < 0.7 and > GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a fourfold higher risk for women.<br> <b>Conclusion:</b> The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV1/FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV1/FVC < 0.7.en_US
dc.descriptionThis is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.<br> The published version is available at <a href="http://dx.doi.org/10.1183/13993003.00443-2016">http://dx.doi.org/10.1183/13993003.00443-2016</a>en_US
dc.identifier.citationEuropean Respiratory Journal (2016), 48: 1602-1611en_US
dc.identifier.cristinIDFRIDAID 1399495
dc.identifier.doi10.1183/13993003.00443-2016
dc.identifier.issn1399-3003
dc.identifier.issn0903-1936
dc.identifier.urihttps://hdl.handle.net/10037/10206
dc.language.isoengen_US
dc.publisherEuropean Respiratory Society: ERJen_US
dc.publisherWileyen_US
dc.rights.accessRightsopenAccessen_US
dc.subjectspirometryen_US
dc.subjectreference valuesen_US
dc.subjectadolescentsen_US
dc.subjectadultsen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777en_US
dc.titleGlobal Lung Function Initiative 2012 reference equations for spirometry in the Norwegian Populationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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