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dc.contributor.authorHwang, Yunji
dc.contributor.authorLee, Kyu Eun
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorPark, Young Joo
dc.contributor.authorChai, Young Jun
dc.contributor.authorKwon, Hyungju
dc.contributor.authorPark, Do Joon
dc.contributor.authorCho, BeLong
dc.contributor.authorChoi, Ho-Chun
dc.contributor.authorKang, Daehee
dc.contributor.authorPark, Sue K
dc.date.accessioned2017-02-24T09:43:15Z
dc.date.available2017-02-24T09:43:15Z
dc.date.issued2016-03-17
dc.description.abstractBackground:<br> This study evaluated the effects of acute high-dose and chronic lifetime exposure to alcohol and exposure patterns on the development of differentiated thyroid cancer (DTC).<br> Methods:<br> The Thyroid Cancer Longitudinal Study (T-CALOS) included 2,258 DTC patients (449 men and 1,809 women) and 22,580 healthy participants (4,490 men and 18,090 women) who were individually matched by age, gender, and enrollment year. In-person interviews were conducted with a structured questionnaire to obtain epidemiologic data. Clinicopathologic features of the patients were obtained by chart reviews. Odds ratios (ORs) and 95% confidence intervals (95%CI) were estimated using conditional regression models.<br> Results:<br> While light or moderate drinking behavior was related to a reduced risk of DTC, acute heavy alcohol consumption (151 g or more per event or on a single occasion) was associated with increased risks in men (OR = 2.22, 95%CI = 1.27–3.87) and women (OR = 3.61, 95%CI = 1.52–8.58) compared with never-drinkers. The consumption of alcohol for 31 or more years was a significant risk factor for DTC for both men (31–40 years: OR = 1.58, 95%CI = 1.10– 2.28; 41+ years: OR = 3.46, 95%CI = 2.06–5.80) and women (31–40 years: OR = 2.18, 95%CI = 1.62–2.92; 41+ years: OR = 2.71, 95%CI = 1.36–5.05) compared with never-drinkers. The consumption of a large amount of alcohol on a single occasion was also a significant risk factor, even after restricting DTC outcomes to tumor size, lymph node metastasis, extrathyroidal extension and TNM stage.<br> Conclusion:<br> The findings of this study suggest that the threshold effects of acute high-dose alcohol consumption and long-term alcohol consumption are linked to an increased risk of DTC.en_US
dc.description.sponsorshipThis study was conducted with research grants from the Korean Foundation for Cancer Research (Grant Number: CB-2011-03-01) and the Basic Research Laboratory Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (Grant Number: 2011-0001564). This study was also supported by the Education and Research Encouragement Fund of Seoul National University Hospital and the Brain Korea 21 PLUS Program. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1371/journal.pone.0151562>doi: 10.1371/journal.pone.0151562</a>en_US
dc.identifier.citationHwang Y, Lee KE, Weiderpass E, Park YJ, Chai YJ, Kwon H, et al. (2016) Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea. PLoS ONE 11(3): e0151562. doi:10.1371/journal. pone.0151562en_US
dc.identifier.cristinIDFRIDAID 1392371
dc.identifier.doi10.1371/journal.pone.0151562
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/10357
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleAcute high-dose and chronic lifetime exposure to alcohol consumption and differentiated thyroid cancer: T-CALOS Koreaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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