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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

dc.contributor.authorRied, Janina S.
dc.contributor.authorJeff, Janina M.
dc.contributor.authorChu, Audrey Y.
dc.contributor.authorBragg-Gresham, Jennifer L.
dc.contributor.authorVan Dongen, Jenny
dc.contributor.authorHuffman, Jennifer E.
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorCadby, Gemma
dc.contributor.authorEklund, Niina
dc.contributor.authorEriksson, Joel
dc.contributor.authorEsko, Tonu
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorGoel, Anuj
dc.contributor.authorGorski, Mathias
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeard-Costa, Nancy L.
dc.contributor.authorJackson, Anne U.
dc.contributor.authorJokinen, Eero
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorKristiansson, Kati
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLahti, Jari
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMägi, Reedik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMangino, Massimo
dc.contributor.authorMedina-Gomez, Carolina
dc.contributor.authorMonda, Keri L.
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorPerusse, Louis
dc.contributor.authorProkopenko, Inga
dc.contributor.authorQi, Lu
dc.contributor.authorRose, Lynda M.
dc.contributor.authorSalvi, Erika
dc.contributor.authorSmith, Megan T.
dc.contributor.authorSnieder, Harold
dc.contributor.authorStandakova, Alena
dc.contributor.authorJu Sung, Yun
dc.contributor.authorTachmazidou, Ioanna
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorVan Der Harst, Pim
dc.contributor.authorWalker, Ryan W.
dc.contributor.authorWang, Sophie R.
dc.contributor.authorWild, Sarah H.
dc.contributor.authorWillems, Stefan M.
dc.contributor.authorWong, Andrew
dc.contributor.authorZhang, Weihua
dc.contributor.authorAlbrecht, Eva
dc.contributor.authorCouto Alves, Alexessander
dc.contributor.authorBakker, Stephan J.L.
dc.contributor.authorBarlassina, Cristina
dc.contributor.authorBartz, Traci M.
dc.contributor.authorBeilby, John
dc.contributor.authorBellis, Claire
dc.contributor.authorBergman, Richard N
dc.contributor.authorBergmann, Sven
dc.contributor.authorBlangero, John
dc.contributor.authorBluher, Matthias
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBonnycastle, Lori L.
dc.contributor.authorBornstein, Stefan R.
dc.contributor.authorBruinenberg, Marcel
dc.contributor.authorCampbell, Harry
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorChiang, Charleston W.K.
dc.contributor.authorChines, Peter S.
dc.contributor.authorCollins, Francis S.
dc.contributor.authorCucca, Fracensco
dc.contributor.authorCupples, L. Adrienne
dc.contributor.authorD'avila, Francesca
dc.contributor.authorde Geus, Eco J.C.
dc.contributor.authorDedoussis, George
dc.contributor.authorDimitriou, Maria
dc.contributor.authorDöring, Angela
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorFarmaki, Aliki-Eleni
dc.contributor.authorFarrall, Martin
dc.contributor.authorFerreira, Teresa
dc.contributor.authorFischer, Krista
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorFriedrich, Nele
dc.contributor.authorGjesing, Anette Prior
dc.contributor.authorGlorioso, Nicola
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorGrallert, Harald
dc.contributor.authorGrarup, Niels
dc.contributor.authorGräßler, Jurgen
dc.contributor.authorGrewal, Jagvir
dc.contributor.authorHamsten, Anders
dc.contributor.authorHarder, Marie Neergaard
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHassinen, Maija
dc.contributor.authorHastie, Nicholas
dc.contributor.authorHattersley, Andrew Tym
dc.contributor.authorHavulinna, Aki S.
dc.contributor.authorHeliövaara, Markku
dc.contributor.authorHillege, Hans
dc.contributor.authorHofman, Albert
dc.contributor.authorHolmen, Oddgeir
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHui, Jennie
dc.contributor.authorHusemoen, Lise Lotte
dc.contributor.authorHysi, Pirro G
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorIttermann, Till
dc.contributor.authorJalilzadeh, Shapour
dc.contributor.authorJames, Alan L
dc.contributor.authorJørgensen, Torben
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorJula, Antti
dc.contributor.authorMarie Justesen, Johanne
dc.contributor.authorJustice, Anne E
dc.contributor.authorKähönen, Mika
dc.contributor.authorKaraleftheri, Maria
dc.contributor.authorTee Khaw, Kay
dc.contributor.authorKeinanen-Kiukaanniemi, Sirkka M
dc.contributor.authorKinnunen, Leena
dc.contributor.authorKnekt, Paul B
dc.contributor.authorKoistinen, Heikki A
dc.contributor.authorKolcic, Ivana
dc.contributor.authorKooner, Ishminder K
dc.contributor.authorKoskinen, Seppo
dc.contributor.authorKovacs, Peter
dc.contributor.authorKyriakou, Theodosios
dc.contributor.authorLaitinen, Tomi
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLewin, Alexandra M
dc.contributor.authorLichtner, Peter
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorLindström, Jaana
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLorbeer, Roberto
dc.contributor.authorLorentzon, Mattias
dc.contributor.authorLuben, Robert
dc.contributor.authorLyssenko, Valeriya
dc.contributor.authorMännistö, Satu
dc.contributor.authorManunta, Paolo
dc.contributor.authorLeach, Irene Mateo
dc.contributor.authorMcardle, Wendy L
dc.contributor.authorMcknight, Barbara
dc.contributor.authorMohlke, Karen L
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMilani, Lili
dc.contributor.authorMills, Rebecca
dc.contributor.authorMontasser, May E
dc.contributor.authorMorris, Andrew P
dc.contributor.authorMuller, Gabriele
dc.contributor.authorMusk, Arthur W
dc.contributor.authorNarisu, Narisu
dc.contributor.authorOng, Ken K
dc.contributor.authorOostra, Ben A
dc.contributor.authorOsmond, Clive
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPankow, James S
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorPenninx, Brenda W
dc.contributor.authorPichler, Irene
dc.contributor.authorPilia, Maria G
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorRao, DC
dc.contributor.authorRayner, Nigel W
dc.contributor.authorRibel-Madsen, Rasmus
dc.contributor.authorRice, Treva K
dc.contributor.authorRichards, Marcus
dc.contributor.authorRidker, Paul M
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRyan, Kathy A
dc.contributor.authorSanna, Serena
dc.contributor.authorSarzynski, Mark A
dc.contributor.authorScholtens, Salome
dc.contributor.authorScott, Robert A
dc.contributor.authorSebert, Sylvain
dc.contributor.authorSoutham, Lorraine
dc.contributor.authorSparsø, Thomas Hempel
dc.contributor.authorSteinthorsdottir, Valgerdur
dc.contributor.authorStirrups, Kathleen
dc.contributor.authorStolk, Ronald P
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorStringham, Heather M
dc.contributor.authorSwertz, Morris A
dc.contributor.authorSwift, Amy J
dc.contributor.authorTönjes, Anke
dc.contributor.authorTsafantakis, Emmanouil
dc.contributor.authorVan Der Most, Peter J
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V
dc.contributor.authorVandenput, Liesbeth
dc.contributor.authorVartiainen, Erkki
dc.contributor.authorVenturini, Cristina
dc.contributor.authorVerweij, Niek
dc.contributor.authorViikari, Jorma S
dc.contributor.authorVitart, Veronique
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorVonk, Judith M
dc.contributor.authorWaeber, Gerard
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWinkler, Thomas W
dc.contributor.authorWright, Alan F
dc.contributor.authorYerges-Armstrong, Laura M
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorCarola Zillikens, M
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorBouchard, Claude
dc.contributor.authorChambers, John C
dc.contributor.authorChasman, Daniel I
dc.contributor.authorCusi, Daniele
dc.contributor.authorGansevoort, Ron T
dc.contributor.authorGieger, Christian
dc.contributor.authorHansen, Torben
dc.contributor.authorHicks, Andrew A
dc.contributor.authorHu, Frank
dc.contributor.authorHveem, Kristian
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKajantie, Eero
dc.contributor.authorKooner, Jaspal S
dc.contributor.authorKuh, Diana
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLaakso, Markku
dc.contributor.authorLakka, Timo A
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorMetspalu, Andres
dc.contributor.authorNjølstad, Inger
dc.contributor.authorOhlsson, Claes
dc.contributor.authorOldehinkel, Albertine J
dc.contributor.authorPalmer, Lyle J
dc.contributor.authorPedersen, Oluf
dc.contributor.authorPerola, Markus
dc.contributor.authorPeters, Annette
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorPuolijoki, Hannu
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorRudan, Igor
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSchwarz, Peter E H
dc.contributor.authorShudiner, Alan R
dc.contributor.authorSmit, Jan H
dc.contributor.authorSørensen, Thorkild I A
dc.contributor.authorSpector, Timothy D
dc.contributor.authorStefansson, Kari
dc.contributor.authorStumvoll, Michael
dc.contributor.authorTremblay, Angelo
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorUusitupa, Matti
dc.contributor.authorVölker, Uwe
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorWatkins, Hugh
dc.contributor.authorWilson, James F
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBorecki, Ingrid B
dc.contributor.authorDeloukas, Panos
dc.contributor.authorVan Duijn, Cornelia M
dc.contributor.authorFox, Caroline
dc.contributor.authorGroop, Leif C
dc.contributor.authorHeid, Iris M
dc.contributor.authorHunter, David J
dc.contributor.authorKaplan, Robert C
dc.contributor.authorMccarthy, Mark I
dc.contributor.authorNorth, Kari E
dc.contributor.authorO'connell, Jeffrey R
dc.contributor.authorSchlessinger, David
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorStrachan, David P
dc.contributor.authorFrayling, Timothy
dc.contributor.authorHirschhorn, Joel N
dc.contributor.authorMuller-Nurasyid, Martina
dc.contributor.authorLoos, Ruth J.F.
dc.date.accessioned2017-02-27T12:38:09Z
dc.date.available2017-02-27T12:38:09Z
dc.date.issued2016-11-23
dc.description.abstractLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1038/ncomms13357>10.1038/ncomms13357</a>en_US
dc.identifier.citationRied, J. S. et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat. Commun. 7, 13357 doi: 10.1038/ncomms13357 (2016)en_US
dc.identifier.cristinIDFRIDAID 1434863
dc.identifier.doi10.1038/ncomms13357
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/10370
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalNature Communications
dc.relation.urihttp://www.readcube.com/articles/10.1038/ncomms13357
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shapeen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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