A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
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https://hdl.handle.net/10037/10370Dato
2016-11-23Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Ried, Janina S.; Jeff, Janina M.; Chu, Audrey Y.; Bragg-Gresham, Jennifer L.; Van Dongen, Jenny; Huffman, Jennifer E.; Ahluwalia, Tarunveer S.; Cadby, Gemma; Eklund, Niina; Eriksson, Joel; Esko, Tonu; Feitosa, Mary F.; Goel, Anuj; Gorski, Mathias; Hayward, Caroline; Heard-Costa, Nancy L.; Jackson, Anne U.; Jokinen, Eero; Kanoni, Stavroula; Kristiansson, Kati; Kutalik, Zoltan; Lahti, Jari; Luan, Jian'an; Mägi, Reedik; Mahajan, Anubha; Mangino, Massimo; Medina-Gomez, Carolina; Monda, Keri L.; Nolte, Ilja M.; Perusse, Louis; Prokopenko, Inga; Qi, Lu; Rose, Lynda M.; Salvi, Erika; Smith, Megan T.; Snieder, Harold; Standakova, Alena; Ju Sung, Yun; Tachmazidou, Ioanna; Teumer, Alexander; Thorleifsson, Gudmar; Van Der Harst, Pim; Walker, Ryan W.; Wang, Sophie R.; Wild, Sarah H.; Willems, Stefan M.; Wong, Andrew; Zhang, Weihua; Albrecht, Eva; Couto Alves, Alexessander; Bakker, Stephan J.L.; Barlassina, Cristina; Bartz, Traci M.; Beilby, John; Bellis, Claire; Bergman, Richard N; Bergmann, Sven; Blangero, John; Bluher, Matthias; Boerwinkle, Eric; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bruinenberg, Marcel; Campbell, Harry; Chen, Yii-Der Ida; Chiang, Charleston W.K.; Chines, Peter S.; Collins, Francis S.; Cucca, Fracensco; Cupples, L. Adrienne; D'avila, Francesca; de Geus, Eco J.C.; Dedoussis, George; Dimitriou, Maria; Döring, Angela; Eriksson, Johan G.; Farmaki, Aliki-Eleni; Farrall, Martin; Ferreira, Teresa; Fischer, Krista; Forouhi, Nita G.; Friedrich, Nele; Gjesing, Anette Prior; Glorioso, Nicola; Graff, Mariaelisa; Grallert, Harald; Grarup, Niels; Gräßler, Jurgen; Grewal, Jagvir; Hamsten, Anders; Harder, Marie Neergaard; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas; Hattersley, Andrew Tym; Havulinna, Aki S.; Heliövaara, Markku; Hillege, Hans; Hofman, Albert; Holmen, Oddgeir; Homuth, Georg; Hottenga, Jouke-Jan; Hui, Jennie; Husemoen, Lise Lotte; Hysi, Pirro G; Isaacs, Aaron; Ittermann, Till; Jalilzadeh, Shapour; James, Alan L; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Marie Justesen, Johanne; Justice, Anne E; Kähönen, Mika; Karaleftheri, Maria; Tee Khaw, Kay; Keinanen-Kiukaanniemi, Sirkka M; Kinnunen, Leena; Knekt, Paul B; Koistinen, Heikki A; Kolcic, Ivana; Kooner, Ishminder K; Koskinen, Seppo; Kovacs, Peter; Kyriakou, Theodosios; Laitinen, Tomi; Langenberg, Claudia; Lewin, Alexandra M; Lichtner, Peter; Lindgren, Cecilia M; Lindström, Jaana; Linneberg, Allan; Lorbeer, Roberto; Lorentzon, Mattias; Luben, Robert; Lyssenko, Valeriya; Männistö, Satu; Manunta, Paolo; Leach, Irene Mateo; Mcardle, Wendy L; Mcknight, Barbara; Mohlke, Karen L; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Montasser, May E; Morris, Andrew P; Muller, Gabriele; Musk, Arthur W; Narisu, Narisu; Ong, Ken K; Oostra, Ben A; Osmond, Clive; Palotie, Aarno; Pankow, James S; Paternoster, Lavinia; Penninx, Brenda W; Pichler, Irene; Pilia, Maria G; Polasek, Ozren; Pramstaller, Peter P; Raitakari, Olli T; Rankinen, Tuomo; Rao, DC; Rayner, Nigel W; Ribel-Madsen, Rasmus; Rice, Treva K; Richards, Marcus; Ridker, Paul M; Rivadeneira, Fernando; Ryan, Kathy A; Sanna, Serena; Sarzynski, Mark A; Scholtens, Salome; Scott, Robert A; Sebert, Sylvain; Southam, Lorraine; Sparsø, Thomas Hempel; Steinthorsdottir, Valgerdur; Stirrups, Kathleen; Stolk, Ronald P; Strauch, Konstantin; Stringham, Heather M; Swertz, Morris A; Swift, Amy J; Tönjes, Anke; Tsafantakis, Emmanouil; Van Der Most, Peter J; Van Vliet-Ostaptchouk, Jana V; Vandenput, Liesbeth; Vartiainen, Erkki; Venturini, Cristina; Verweij, Niek; Viikari, Jorma S; Vitart, Veronique; Vohl, Marie-Claude; Vonk, Judith M; Waeber, Gerard; Widen, Elisabeth; Willemsen, Gonneke; Wilsgaard, Tom; Winkler, Thomas W; Wright, Alan F; Yerges-Armstrong, Laura M; Zhao, Jing Hua; Carola Zillikens, M; Boomsma, Dorret I; Bouchard, Claude; Chambers, John C; Chasman, Daniel I; Cusi, Daniele; Gansevoort, Ron T; Gieger, Christian; Hansen, Torben; Hicks, Andrew A; Hu, Frank; Hveem, Kristian; Jarvelin, Marjo-Riitta; Kajantie, Eero; Kooner, Jaspal S; Kuh, Diana; Kuusisto, Johanna; Laakso, Markku; Lakka, Timo A; Lehtimäki, Terho; Metspalu, Andres; Njølstad, Inger; Ohlsson, Claes; Oldehinkel, Albertine J; Palmer, Lyle J; Pedersen, Oluf; Perola, Markus; Peters, Annette; Psaty, Bruce M; Puolijoki, Hannu; Rauramaa, Rainer; Rudan, Igor; Salomaa, Veikko; Schwarz, Peter E H; Shudiner, Alan R; Smit, Jan H; Sørensen, Thorkild I A; Spector, Timothy D; Stefansson, Kari; Stumvoll, Michael; Tremblay, Angelo; Tuomilehto, Jaakko; Uitterlinden, Andre G; Uusitupa, Matti; Völker, Uwe; Vollenweider, Peter; Wareham, Nicholas J; Watkins, Hugh; Wilson, James F; Zeggini, Eleftheria; Abecasis, Goncalo R; Boehnke, Michael; Borecki, Ingrid B; Deloukas, Panos; Van Duijn, Cornelia M; Fox, Caroline; Groop, Leif C; Heid, Iris M; Hunter, David J; Kaplan, Robert C; Mccarthy, Mark I; North, Kari E; O'connell, Jeffrey R; Schlessinger, David; Thorsteinsdottir, Unnur; Strachan, David P; Frayling, Timothy; Hirschhorn, Joel N; Muller-Nurasyid, Martina; Loos, Ruth J.F.Sammendrag
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
Beskrivelse
Source: 10.1038/ncomms13357
Forlag
Nature Publishing GroupSitering
Ried, J. S. et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat. Commun. 7, 13357 doi: 10.1038/ncomms13357 (2016)Metadata
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M.; Aldhahri, Saleh Fahed; Alegretti, Miguel Angel; Alemu, Zewdie Aderaw; Alexander, Lily T.; Alhabib, Samia; Ali, Raghib; Alkerwi, Ala'a; Alla, Francois; Allebeck, Peter; Al-Raddadi, Rajaa; Alsharif, Ubai; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Amare, Azmeraw T.; Amberbir, Alemayehu; Amini, Heresh; Ammar, Walid; Amrock, Stephen Marc; Andersen, Hjalte H.; Anderson, Gregory M.; Anderson, Benjamin; Antonio, Carl Abelardo T.; Aregay, Atsede Fantahun; Arnlov, Johan; Artaman, Al; Asayesh, Hamid; Assadi, Reza; Atique, Suleman; Avokpaho, Euripide Frinel G. Arthur; Awasthi, Ashish; Quintanilla, Beatriz Paulina Ayala; Azzopardi, Peter; Bacha, Umar; Badawi, Alaa; Balakrishnan, Kalpana; Banerjee, Amitava; Barac, Aleksandra; Barker-Collo, Suzanne L.; Bärnighausen, Till; Barregard, Lars; Barrero, Lope H.; Basu, Arindam; Bazargan-Hejazi, Shahrzad; Bell, Brent; Bell, Michelle L.; Bennett, Derrick A.; Bensenor, Isabela M.; Benzian, Habib; Berhane, Adugnaw; Bernabe, Eduardo; Betsu, Balem Demtsu; Beyene, Addisu Shunu; Bhala, Neeraj; Bhatt, Samir; Biadgilign, Sibhatu; Bienhofff, Kelly; Bikbov, Boris; Biryukov, Stan; Bisanzio, Donal; Bjertness, Espen; Blore, Jed; Borschmann, Rohan; Boufous, Soufiane; Brainin, Michael; Brazinova, Alexandra; Breitborde, Nicholas J. K.; Brown, Jonathan; Buchbinder, Rachelle; Buckle, Geoffrey Colin; Butt, Zahid A.; Calabria, Bianca; Campos-Nonato, Ismael Ricardo; Campuzano, Julio Cesar; Carabin, Helene; Cardenas, Rosario; Carpenter, David O.; Carrero, Juan Jesus; Castaneda-Orjuela, Carlos A.; Rivas, Jacqueline Castillo; Catala-Lopez, Ferran; Chang, Jung-Chen; Chiang, Peggy Pei-Chia; Chibueze, Chioma Ezinne; Chisumpa, Vesper Hichilombwe; Choi, Jee-Young Jasmine; Chowdhury, Rajiv; Christensen, Hanne; Christopher, Devasahayam Jesudas; Ciobanu, Liliana G.; Cirillo, Massimo; Coates, Matthew M.; Colquhoun, Samantha M; Cooper, Cyrus; Cortinovis, Monica; Crump, John A.; Damtew, Solomon Abrha; Dandona, Rakhi; Daoud, Farah; Dargan, Paul I.; das Neves, Jose; Davey, Gail; Davis, Adrian C.; De Leo, Diego; Degenhardt, Louisa; Del Gobbo, Liana C; Dellavalle, Robert P; Deribe, Kebede; Deribew, Amare; Derrett, Sarah; Des Jarlais, Don C.; Dharmaratne, Samath D.; Dhillon, Preet K.; Diaz-Torne, Cesar; Ding, Eric L.; Driscoll, Tim R.; Duan, Leilei; Dubey, Manisha; Duncan, Bruce Bartholow; Ebrahimi, Hedyeh; Ellenbogen, Richard G.; Elyazar, Iqbal; Endres, Matthias; Endries, Aman Yesuf; Ermakov, Sergey Petrovich; Eshrati, Babak; Estep, Kara; Farid, Talha A; Farinha, Carla Sofia e Sa; Faro, Andre; Farvid, Maryam S.; Farzadfar, Farshad; Feigin, Valery L.; Felson, David T.; Fereshtehnejad, Seyed-Mohammad; Fernandes, Jefferson G.; Fernandes, Joao C.; Fischer, Florian; Fitchett, Joseph R. A.; Foreman, Kyle; Fowkes, Gerry R.; Fox, Jordan; Franklin, Richard C.; Friedman, Joseph; Frostad, Joseph; Furst, Thomas; Futran, Neal D.; Gabbe, Belinda; Ganguly, Parthasarathi; Gankpe, Fortune Gbetoho; Gebre, Teshome; Gebrehiwot, Tsegaye Tewelde; Gebremedhin, Amanuel Tesfay; Geleijnse, Johanna M.; Gessner, Bradford D.; Gibney, Katherine B.; Ginawi, Ibrahim Abdelmageem Mohamed; Giref, Ababi Zergaw; Giroud, Maurice; Gishu, Melkamu Dedefo; Glaser, Elizabeth; Godwin, William W.; Gomez-Dantes, Hector; Gona, Philimon; Goodridge, Amador; Gopalani, Sameer Vali; Gotay, Carolyn C.; Goto, Atsushi; Gouda, Hebe N.; Grainger, Rebecca; Greaves, Felix; Guillemin, Francis; Guo, Yuming; Gupta, Rahul; Gupta, Rajeev; Gupta, Vipin; Gutierrez, Reyna A.; Haile, Demewoz; Hailu, Gessessew Bugssa; Halasa, Yara A.; Hamadeh, Randah Ribhi; Hamidi, Samer; Hammami, Mouhanad; Hancock, Jamie; Handal, Alexis J.; Hankey, Graeme J.; Hao, Yuantao; Harb, Hilda L.; Harikrishnan, Sivadasanpillai; Haro, Josep Maria; Havmoeller, Rasmus; Hay, Roderick J.; Heredia-Pi, Ileana Beatriz; Heydarpour, Pouria; Hoek, Hans W.; Horino, Masako; Horita, Nobuyuki; Hosgood, H. Dean; Hoy, Damian G.; Htet, Aung Soe; Huang, Hsiang; Huang, John J.; Huynh, Chantal; Iannarone, Marissa; Iburg, Kim Moesgaard; Innos, Kaire; Inoue, Manami; Iyer, Veena J.; Jacobsen, Kathryn H.; Jahanmehr, Nader; Jakovljevic, Mihajlo B.; Javanbakht, Mehdi; Jayatilleke, Achala Upendra; Jee, Sun Ha; Jeemon, Panniyammakal; Jensen, Paul N.; Jiang, Ying; Jibat, Tariku; Jimenez-Corona, Aida; Jin, Ye; Jonas, Jost B.; Kabir, Zubair; Kalkonde, Yogeshwar; Kamal, Ritul; Kan, Haidong; Karch, Andre; Karema, Corine Kakizi; Karimkhani, Chante; Kasaeian, Amir; Kau, Anil; Kawakami, Norito; Keiyoro, Peter Njenga; Kemp, Andrew Haddon; Keren, Andre; Kesavachandran, Chandrasekharan Nair; Khader, Yousef Saleh; Khaiff, Abdur Rahman; Khaiff, Ejaz Ahmad; Khang, Young-Ho; Khera, Sahil; Khoja, Tawfik Ahmed Muthafer; Khubchandani, Jagdish; Kieling, Christian; Kim, Pauline; Kim, Cho-il; Kim, Daniel; Kim, Yun Jin; Kissoon, Niranjan; Knibbs, Luke D.; Knudsen, Ann Kristin; Kokubo, Yoshihiro; Kolte, Dhaval; Kopec, Jacek A.; Kosen, Soewarta; Kotsakis, Georgios A.; Koul, Parvaiz A.; Koyanagi, Ai; Kravchenko, Michael; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kudom, Andreas A.; Kuipers, Ernst J.; Kumar, G. Anil; Kutz, Michael; Kwan, Gene F.; Lal, Aparna; Lalloo, Ratilal; Lallukka, Tea; Lam, Hilton; Lam, Jennifer O.; Langan, Sinead M.; Larsson, Anders; Lavados, Pablo M.; Leasher, Janet L.; Leigh, James; Leung, Ricky; Levi, Miriam; Li, Yichong; Liang, Juan; Liu, Shiwei; Lloyd, Belinda K.; Lo, Warren D.; Logroscino, Giancarlo; Looker, Katharine J.; Lotufo, Paulo A.; Lunevicius, Raimundas; Lyons, Ronan A.; Mackay, Mark T.; Abd El Razek, Mohammed Magdy; Majdan, Marek; Majeed, Azeem; Malekzadeh, Reza; Marcenes, Wagner; Margolis, David Joel; Martinez-Raga, Jose; Masiye, Felix; Massano, João; McGarvey, Stephen Theodore; McGrath, John J.; McKee, Martin; McMahon, Brian J.; Meaney, Peter A.; Mehari, Alem; Meija-Rodriguez, Fabiola; Mekonnen, Alemayehu B.; Melaku, Yohannes Adama; Memiah, Peter; Memish, Ziad A.; Mendoza, Walter; Meretoja, Atte; Meretoja, Tuomo J.; Mhimbira, Francis Apolinary; Miller, Ted R.; Mills, Edward J; Mirarefin, Mojde; Mitchell, Philip B.; Mock, Charles N.; Mohammadi, Alireza; Mohammed, Shafiu; Monasta, Lorenzo; Montanez Hernandez, Julio Cesar; Montico, Marcella; Mooney, Meghan D.; Moradi-Lakeh, Maziar; Morawska, Lidia; Mueller, Ulrich O.; Mullany, Erin C.; Mumford, John Everett; Murdoch, Michele E.; Nachega, Jean B.; Nagel, Gabriele; Naheed, Aliya; Naldi, Luigi; Nangia, Vinay; Newton, John N.; Ng, Marie; Norheim, Ole Frithjof; Ngalesoni, Frida Namnyak; Hailu, Alemayehu; Savic, Miloje; Skirbekk, Vegard; Skogen, Jens Christoffer; Stovner, Lars Jacob; Steiner, Timothy J.; Søreide, Kjetil; Vollset, Stein Emil; Weiderpass, Elisabete; White, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-08)Background:<br>Non-fatal outcomes of disease and injury increasingly detract from the ability of the world’s population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes aff ecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), ... -
Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants
Zhou, Bin; Lu, Yuan; Hajifathalian, Kaveh; Bentham, James; Di Cesare, Mariachiara; Danaei, Goodarz; Bixby, Honor; Cowan, Melanie J; Ali, Mohammed K; Taddei, Cristina; Lo, Wei-Cheng; Reis-Santos, Barbara; Stevens, Gretchen A.; Riley, Leanne M.; Miranda, J. Jaime; Bjerregaard, Peter; Rivera, Juan A.; Fouad, Heba M.; Ma, Guansheng; Mbanya, Jean Claude N.; McGarvey, Stephen T.; Mohan, Viswanathan; Onat, Altan; Pilav, Aida; Ramachandran, Ambady; Ben Romdhane, Habiba; Paciorek, Christopher J.; Bennett, James E.; Ezzati, Majid; Abdeen, Ziad A.; Kadir, Khalid Abdul; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Adams, Robert; Aekplakorn, Wichai; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmadvand, Alireza; Al-Othman, Amani Rashed; Alkerwi, Ala'a; Amouyel, Philippe; Amuzu, Antoinette; Bo Andersen, Lars; Anderssen, Sigmund Alfred; Anjana, Ranjit Mohan; Aounallah-Skhiri, Hajer; Aris, Tahir; Arlappa, Nimmathota; Arveiler, Dominique; Assah, Felix K.; Avdicova, Maria; Azizi, Fereidoun; Balakrishna, Nagalla; Bandosz, Piotr; Barbagallo, Carlo M.; Barcelo, Alberto; Batieha, Anwar M.; Baur, Louise A.; Benet, Mikhail; Bernabe-Ortiz, Antonio; Bharadwaj, Sumit; Bhargava, Santosh K.; Bi, Yufang; Bjertness, Espen; Bjertness, Marius Bergsmark; Björkelund, Cecilia; Blokstra, Anneke; Bo, Simona; Boehm, Bernhard O; Boissonnet, Carlos P; Bovet, Pascal; Brajkovich, Imperia; Breckenkamp, Juergen; Brenner, Hermann; Brewster, Lizzy M; Brian, Garry R; Bruno, Graziella; Bugge, Anna; De Leon, Antonio Cabrera; Can, Gunay; Cåndido, Ana Paula C; Capuano, Vincenzo; Carlsson, Axel C; Carvalho, Maria J; Casanueva, Felipe F; Casas, Juan-Pablo; Caserta, Carmelo A; Castetbon, Katia; Chamukuttan, Snehalatha; Chaturvedi, Nishi; Chen, Chien-Jen; Chen, Fangfang; Chen, Shuohua; Cheng, Ching-Yu; Chetrit, Angela; Chiou, Shu-Ti; Cho, Yumi; Chudek, Jerzy; Cifkova, Renata; Claessens, Frank; Concin, Hans; Cooper, Cyrus; Cooper, Rachel; Costanzo, Simona; Cottel, Dominique; Cowell, Chris; Crujeiras, Ana B; D'Arrigo, Graziella; Dallongeville, Jean; Dankner, Rachel; Dauchet, Luc; De Gaetano, Giovanni; De Henauw, Stefaan; Deepa, Mohan; Dehghan, Abbas; Deschamps, Valerie; Dhana, Klodian; Di Castelnuovo, Augusto F; Djalalinia, Shirin; Doua, Kouamelan; Drygas, Wojciech; Du, Yong; Dzerve, Vilnis; Egbagbe, Eruke E; Eggertsen, Robert; El Ati, Jalila; Elosua, Roberto; Erasmus, Rajiv T; Erem, Cihangir; Ergor, Gul; Eriksen, Louise; Escobedo-De La Pena, Jorge; Fall, Caroline H; Farzadfar, Farshad; Felix-Redondo, Francisco J; Ferguson, Trevor S; Fernandez-Berges, Daniel; Ferrari, Marika; Ferreccio, Catterina; Feskens, Edith JM; Finn, Joseph D; Föger, Bernhard; Foo, Leng Huat; Forslund, Ann-Sofie; Francis, Damian K; Do Carmo Franco, Maria; Franco, Oscar H; Frontera, Guillermo; Furusawa, Takuro; Gaciong, Zbigniew; Garnett, Sarah P; Gaspoz, Jean-Michel; Gasull, Magda; Gates, Louise; Geleijnse, Johanna M; Ghasemian, Anoosheh; Ghimire, Anup; Giampaoli, Simona; Gianfagna, Francesco; Giovannelli, Jonathan; Giwercman, Aleksander; Gross, Marcela Gonzalez; Rivas, Juan P Gonzalez; Gorbea, Mariano Bonet; Gottrand, Frederic; Grafnetter, Dusan; Grodzicki, Tomasz; Grøntved, Anders; Gruden, Grabriella; Gu, Dongfeng; Guan, Ong Peng; Guerrero, Ramiro; Guessous, Idris; Guimaraes, Andre L; Gutierrez, Laura; Hambleton, Ian R; Hardy, Rebecca; Kumar, Rachakulla Hari; Hata, Jun; He, Jiang; Heidemann, Christin; Herrala, Sauli; Hihtaniemi, Ilpo Tapani; Ho, Sai Yin; Ho, Suzanne C; Hofman, Albert; Hormiga, Claudia M; Horta, Bernardo L; Houti, Leila; Howitt, Christina; Htay, Thein Thein; Htet, Aung Soe; Htike, Maung Maung Than; Hu, Yang; Hussieni, Abdullatif S; Huybrechts, Inge; Hwalla, Nahla; Iacoviello, Licia; Iannone, Anna G; Ibrahim, M Mohsen; Ikeda, Nayu; Ikram, M Arfan; Irazola, Vilma E; Islam, Muhammad; Iwasaki, Masanori; Jacobs, Jeremy M; Jafar, Tazeen; Jamil, Kazi M; Jasienska, Grazyna; Jiang, Chao Qiang; Jonas, Jost B; Joshi, Pradeep; Kafatos, Anthony; Kalter-Leibovici, Ofra; Kasaeian, Amir; Katz, Joanne; Kaur, Prabhdeep; Kavousi, Maryam; Keinänen-Kiukaanniemi, Sirkka; Kelishadi, Roya; Kengne, Andre P; Kersting, Mathilde; Khader, Yousef Saleh; Khalili, Davood; Khang, Young-Ho; Kiechl, Stefan; Kim, Jeongseon; Kolsteren, Patrick; Korrovits, Paul; Kratzer, Wolfgang; Kromhout, Daan; Kujala, Urho M; Kula, Krzysztof; Kyobutungi, Catherine; Laatikainen, Tiina; Lachat, Carl; Laid, Youcef; Lam, Tai Hing; Landrove, Orlando; Lanska, Vera; Lappas, Georg; Laxmaiah, Avula; Leclercq, Catherine; Lee, Jeannette; Lee, Jeonghee; Lehtimäki, Terho; Lekhraj, Rampal; Leon-Munoz, Luz M; Li, Yanping; Lim, Wei-Yen; Lima-Costa, M Fernanda; Lin, Hsien-Ho; Lin, Xu; Lissner, Lauren; Lorbeer, Roberto; Lozano, Jose Eugenio; Luksiene, Dalia; Lundqvist, Annamari; Lytsy, Per; Machado-Coelho, George LL; Machi, Suka; Maggi, Stefania; Magliano, Dianna J; Makdisse, Marcia; Rao, Kodavanti Mallikharjuna; Manios, Yannis; Manzato, Enzo; Margozzini, Paula; Marques-Vidal, Pedro; Martorell, Reynaldo; Masoodi, Shariq R; Mathiesen, Ellisiv B.; Matsha, Tandi E; McFarlane, Shelly R; McLachlan, Stela; McNulty, Breige A; Mediene-Benchekor, Sounnia; Meirhaeghe, Aline; Menezes, Ana Maria B; Merat, Shahin; Meshram, Indrapal I; Mi, Jie; Miquel, Juan Francisco; Mohamed, Mostafa K; Mohammad, Kazem; Mohammadifard, Noushin; Mohd Yusoff, Muhammad Fadhli; Møller, Niels C; Molnar, Denes; Mondo, Charles K; Morejon, Alain; Moreno, Luis A; Morgan, Karen; Moschonis, George; Mossakowska, Malgorzata; Mostafa, Aya; Mota, Jorge; Motta, Jorge; Mu, Thet Thet; Muiesan, Maria Lorenza; Muller-Nurasyid, Martina; Mursu, Jaakko; Nagel, Gabriele; Namesna, Jana; Nang, Ei Ei K; Nangia, Vinay B; Navarrete-Munoz, Eva Maria; Ndiaye, Ndeye Coumba; Nenko, Ilona; Nervi, Flavio; Nguyen, Nguyen D; Nguyen, Quang Ngoc; Nieto-Martinez, Ramfis E; Ning, Guang; Ninomiya, Toshiharu; Noale, Marianna; Noto, Davide; Al Nsour, Mohannad; Ochoa-Aviles, Angelica M; Oh, Kyungwon; Ordunez, Pedro; Osmond, Clive; Otero, Johanna A; Owusu-Dabo, Ellis; Pahomova, Elena; Palmieri, Luigi; Panda-Jonas, Songhomitra; Panza, Francesco; Parsaeian, Mahboubeh; Peixoto, Sergio Viana; Peltonen, Markku; Peters, Annette; Peykari, Niloofar; Pham, Son Thai; Pitakaka, Freda; Piwonska, Aleksandra; Piwonski, Jerzy; Plans-Rubio, Pedro; Porta, Miquel; Portegies, Marileen LP; Poustchi, Hossein; Pradeepa, Rajendra; Price, Jacqueline F; Punab, Margus; Qasrawi, Radwan F; Qorbani, Mostafa; Radisauskas, Ricardas; Rahman, Mahmudur; Raitakari, Olli; Rao, Sudha Ramachandra; Ramke, Jacqueline; Ramos, Rafel; Rampal, Sanjay; Rathmann, Wolfgang; Redon, Josep; Reganit, Paul Ferdinand M; Rigo, Fernando; Robinson, Sian M; Robitaille, Cynthia; Rodriguez-Artalejo, Fernando; Del CristoRodriguez-Perez, Maria; Rodriguez-Villamizar, Laura A; Rojas-Martinez, Rosalba; Ronkainen, Kimmo; Rosengren, Annika; Rubinstein, Adolfo; Rui, Ornelas; Ruiz-Betancourt, Blanca Sandra; Horimoto, Andrea RV Russo; Rutkowski, Marcin; Sabanayagam, Charumathi; Sachdev, Harshpal S; Saidi, Olfa; Sakarya, Sibel; Salanave, Benoit; Salonen, Jukka T; Salvetti, Massimo; Sanchez-Abanto, Jose; Santos, Diana; Dos Santos, Renata Nunes; Santos, Rute; Saramies, Jouko L; Sardinha, Luis B; Sarrafzadegan, Nizal; Saum, Kai-Uwe; Scazufca, Marcia; Schargrodsky, Herman; Scheidt-Nave, Christa; Sein, Aye Aye; Sharma, Sanjb K; Shaw, Jonathan E; Shibuya, Kenji; Shin, Youchan; Shiri, Rahman; Siantar, Rosalynn; Sibai, Abla M; Simon, Mary; Simons, Judith; Simons, Leon A; Sjostrom, Michael; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemyslaw; Smeeth, Liam; Snijder, Marieke B; So, Hung-Kwan; Sobngwi, Eugene; Söderberg, Stefan; Solfrizzi, Vincenzo; Sonestedt, Emily; Soumare, Aicha; Staessen, Jan A; Stathopoulou, Maria G; Steene-Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D; Stessman, Jochanan; Stöckl, Doris; Stokwiszewski, Jakub; Stronks, Karien; Strufaldi, Maria Wany; Sun, Chien-An; Sundström, Johan; Sung, Yn-Tz; Suriyawongpaisal, Paibul; Sy, Rody G; Tai, E Shyong; Tamosiunas, Abdonas; Tang, Line; Tarawneh, Mohammed; Tarqui-Mamani, Carolina B; Taylor, Anne; Theobald, Holger; Thijs, Lutgarde; Thuesen, Betina H; Tolonen, Hanna K; Tolstrup, Janne S; Topbas, Murat; Torrent, Maties; Traissac, Pierre; Trinh, Oanh TH; Tulloch-Reid, Marshall K; Tuomainen, Tomi-Pekka; Turley, Maria L; Tzourio, Christophe; Ueda, Peter; Ukoli, Flora AM; Ulmer, Hanno; Uusitalo, Hannu MT; Valdivia, Gonzalo; Valvi, Damaskini; Van Rossem, Lenie; Van Valkengoed, Irene GM; Vanderschueren, Dirk; Vanuzzo, Diego; Vega, Tomas; Velasquez-Melendez, Gustavo; Veronesi, Giovanni; Verschuren, WM Monique; Verstraeten, Roosmarijn; Viet, Lucie; Vioque, Jesus; Virtanen, Jyrki K; Visvikis-Siest, Sophie; Viswanathan, Bharathi; Vollenweider, Peter; Voutilainen, Sari; Vrijheid, Martine; Wade, Alisha N; Wagner, Aline; Walton, Janette; Wan Mohamud, Wan Nazaimoon; Wang, Feng; Wang, Ming-Dong; Wang, Qian; Wang, Ya Xing; Wannamethee, S Goya; Weerasekera, Deepa; Whincup, Peter H; Widhalm, Kurt; Wiecek, Andrzej; Wijga, Alet H; Wilks, Rainford J; Willeit, Johann; Wilsgaard, Tom; Wojtyniak, Bogdan; Wong, Tien Yin; Woo, Jean; Woodward, Mark; Wu, Frederick C; Wu, Shou Ling; Xu, Haiquan; Yan, Weili; Yang, Xiaoguang; Ye, Xingwang; Yoshihara, Akihiro; Younger-Coleman, Novie O; Zambon, Sabina; Zargar, Abdul Hamid; Zdrojewski, Tomasz; Zhao, Wenhua; Zheng, Yingfeng; Cisneros, Julio Zuñiga (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-09)Background:<br>One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the agestandardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults ...