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dc.contributor.authorAstor, Marianne
dc.contributor.authorLøvås, Kristian
dc.contributor.authorDebowska, Aleksandra
dc.contributor.authorEriksen, Erik Fink
dc.contributor.authorEvang, Johan Arild
dc.contributor.authorFossum, Jan Christian
dc.contributor.authorFougner, Kristian J
dc.contributor.authorHolte, Synnøve E.
dc.contributor.authorLima, Kari
dc.contributor.authorMoe, Ragnar Bekkhus
dc.contributor.authorMyhre, Anne Grethe
dc.contributor.authorKemp, E. Helen
dc.contributor.authorNedrebø, Bjørn Gunnar
dc.contributor.authorSvartberg, Johan
dc.contributor.authorHusebye, Eystein Sverre
dc.date.accessioned2017-03-06T12:34:22Z
dc.date.available2017-03-06T12:34:22Z
dc.date.issued2016-05-17
dc.description.abstract<b>Objective:</b> The epidemiology of hypoparathyroidism (HP) is largely unknown. We aimed to determine prevalence, etiologies, health related quality of life (HRQOL) and treatment pattern of HP.<br> <b>Methods:</b> Patients with HP and 22q11 deletion syndrome (DiGeorge syndrome) were identified in electronic hospital registries. All identified patients were invited to participate in a survey. Among patients who responded, HRQOL was determined by Short Form 36 and Hospital Anxiety and Depression scale. Autoantibodies were measured and candidate genes (CaSR, AIRE, GATA3, and 22q11-deletion) were sequenced for classification of etiology.<br> <b>Results:</b> We identified 522 patients (511 alive) and estimated overall prevalence at 102 per million divided among postsurgical HP (64 per million), nonsurgical HP (30 per million), and pseudo-HP (8 per million). Nonsurgical HP comprised autosomal dominant hypocalcemia (21%), autoimmune polyendocrine syndrome type 1 (17%), DiGeorge/22q11 deletion syndrome (15%), idiopathic HP (44%), and others (4%). Among the 283 respondents (median age, 53 years [range, 9 – 89], 75% females), seven formerly classified as idiopathic were reclassified after genetic and immunological analyses, whereas 26 (37% of nonsurgical HP) remained idiopathic.Most were treated with vitamin D (94%) and calcium (70%), and 10 received PTH. HP patients scored significantly worse than the normative population on Short Form 36 and Hospital Anxiety and Depression scale; patients with postsurgical scored worse than those with nonsurgical HP and pseudo-HP, especially on physical health. <br><b>Conclusions:</b> We found higher prevalence of nonsurgical HP in Norway than reported elsewhere. Genetic testing and autoimmunity screening of idiopathic HP identified a specific cause in 21%. Further research is necessary to unravel the causes of idiopathic HP and to improve the reduced HRQOL reported by HP patientss. (J Clin Endocrinol Metab 101: 3045–3053, 2016)en_US
dc.descriptionAccepted manuscript version. Published version available at <a href=http://dx.doi.org/10.1210/jc.2016-1477>http://dx.doi.org/10.1210/jc.2016-1477</a>en_US
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism 2016, 101(8):3045-3053en_US
dc.identifier.cristinIDFRIDAID 1357197
dc.identifier.doi10.1210/jc.2016-1477
dc.identifier.issn0021-972X
dc.identifier.urihttps://hdl.handle.net/10037/10438
dc.language.isoengen_US
dc.publisherEndocrine Societyen_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.titleEpidemiology and health related quality of life in hypoparathyroidism in Norwayen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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