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dc.contributor.authorDelanaye, Pierre
dc.contributor.authorEbert, Natalie
dc.contributor.authorMelsom, Toralf
dc.contributor.authorGasperi, Flavia
dc.contributor.authorMariat, Christophe
dc.contributor.authorCavalier, Etienne
dc.contributor.authorBjörk, Jonas
dc.contributor.authorChristensson, Anders
dc.contributor.authorNyman, Ulf
dc.contributor.authorPorrini, Esteban
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorRuggenenti, Piero
dc.contributor.authorSchaeffner, Elke
dc.contributor.authorSoveri, Inga
dc.contributor.authorSterner, Gunnar
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorBäck, Sten-Erik
dc.date.accessioned2017-03-10T15:52:56Z
dc.date.available2017-03-10T15:52:56Z
dc.date.issued2016-08-23
dc.description.abstractWhile there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose.As the gold standardmethod for GFR determination, urinary (or renal) clearance of inulin, fades into the background due to inconvenience and high cost, a diversity of filtrationmarkers and protocols compete to replace it. In this review, we suggest that iohexol, a non-ionic contrast agent, is most suited to replace inulin as the marker of choice for GFR determination. Iohexol comes very close to fulfilling all requirements for an ideal GFRmarker in terms of low extra-renal excretion, low protein binding and in being neither secreted nor reabsorbed by the kidney. In addition, iohexol is virtually non-toxic and carries a low cost. As iohexol is stable in plasma, administration and sample analysis can be separated in both space and time, allowing access to GFR determination across different settings. An external proficiency programme operated by Equalis AB, Sweden, exists for iohexol, facilitating interlaboratory comparison of results. Plasma clearance measurement is the protocol of choice as it combines a reliable GFR determination with convenience for the patient. Single-sample protocols dominate, butmultiple-sample protocolsmay bemore accurate in specific situations. In lowGFRs one ormore late samples should be included to improve accuracy. In patients with large oedema or ascites, urinary clearance protocols should be employed. In conclusion, plasma clearance of iohexol may well be the best candidate for a common GFR determination method.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1093/ckj/sfw070> http://dx.doi.org/10.1093/ckj/sfw070 </a>en_US
dc.identifier.citationDelanaye, P. et.al.: Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol? . Clinical Kidney Journal. 2016;9(5):682-699en_US
dc.identifier.cristinIDFRIDAID 1415028
dc.identifier.doi10.1093/ckj/sfw070
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.urihttps://hdl.handle.net/10037/10555
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalClinical Kidney Journal
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectglomerular filtration rateen_US
dc.subjectiohexolen_US
dc.titleIohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol?en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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