Show simple item record

dc.contributor.authorHalvorsen, Bente
dc.contributor.authorSantilli, Francesca
dc.contributor.authorScholz, Hanne
dc.contributor.authorSahraoui, Afaf
dc.contributor.authorGulseth, Hanne Løvdal
dc.contributor.authorWium, Cecilie
dc.contributor.authorLattanzio, Stefano
dc.contributor.authorFormoso, Gloria
dc.contributor.authorDi Fulvio, Patrizia
dc.contributor.authorOtterdal, Kari
dc.contributor.authorRetterstøl, Kjetil
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorGregersen, Ida
dc.contributor.authorStavik, Benedicte
dc.contributor.authorBjerkeli, Vigdis
dc.contributor.authorMichelsen, Annika
dc.contributor.authorUeland, Thor
dc.contributor.authorLiani, Rossella
dc.contributor.authorDavi, Giovanni
dc.contributor.authorAukrust, Pål
dc.date.accessioned2017-03-11T10:22:02Z
dc.date.available2017-03-11T10:22:02Z
dc.date.issued2016-07-15
dc.description.abstractAims/hypothesis: Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) could be involved in the pathogenesis of type 2 diabetes mellitus. <p>Methods: Plasma levels of LIGHT were measured in two cohorts of type 2 diabetes mellitus patients (191 Italian and 40 Norwegian). Human pancreatic islet cells and arterial endothelial cells were used to explore regulation and relevant effects of LIGHT in vitro. <p>Results: Our major findings were: (1) in both diabetic cohorts, plasma levels of LIGHT were significantly raised compared with sex- and age-matched healthy controls (n = 32); (2) enhanced release from activated platelets seems to be an important contributor to the raised LIGHT levels in type 2 diabetes mellitus; (3) in human pancreatic islet cells, inflammatory cytokines increased the release of LIGHT and upregulated mRNA and protein levels of the LIGHT receptors lymphotoxin β receptor (LTβR) and TNF receptor superfamily member 14 (HVEM/TNFRSF14); (4) in these cells, LIGHT attenuated the insulin release in response to high glucose at least partly via pro-apoptotic effects; and (5) in human arterial endothelial cells, glucose boosted inflammatory response to LIGHT, accompanied by an upregulation of mRNA levels of HVEM (also known as TNFRSF14) and LTβR (also known as LTBR). <p>Conclusions/interpretation: Our findings show that patients with type 2 diabetes mellitus are characterised by increased plasma LIGHT levels. Our in vitro findings suggest that LIGHT may contribute to the progression of type 2 diabetes mellitus by attenuating insulin secretion in pancreatic islet cells and by contributing to vascular inflammation.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1007/s00125-016-4036-y> http://dx.doi.org/10.1007/s00125-016-4036-y </a>en_US
dc.identifier.citationHalvorsen BE. et.al.: LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro. Diabetologia. 2016;59:2134-2144en_US
dc.identifier.cristinIDFRIDAID 1374289
dc.identifier.doi10.1007/s00125-016-4036-y
dc.identifier.issn0012-186X
dc.identifier.issn1432-0428
dc.identifier.urihttps://hdl.handle.net/10037/10576
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalDiabetologia
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectCytokinesen_US
dc.subjectEndothelial cellsen_US
dc.subjectInflammationen_US
dc.subjectInsulinen_US
dc.subjectIsletsen_US
dc.subjectType 2 diabetesen_US
dc.titleLIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitroen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record