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dc.contributor.authorStrand, Bjørn Heine
dc.contributor.authorCooper, Rachel
dc.contributor.authorBergland, Astrid
dc.contributor.authorJørgensen, Lone
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorSkirbekk, Vegard
dc.contributor.authorEmaus, Nina
dc.date.accessioned2017-03-13T14:08:13Z
dc.date.available2017-03-13T14:08:13Z
dc.date.issued2016-08-25
dc.description.abstract<b>Background</b> Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-speci fi c mortality or tested age differences in these associations. <b>Methods</b> In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50 – 80 years (N=6850). Grip strength was categorised into fi fths, and as z-scores. In this cohort study, models with all-cause mortality and deaths from speci fi c causes as the outcome were performed, strati fi ed by sex and age using Cox regression, adjusting for lifestyle-related and health-related factors. <b>Results</b> During 17 years of follow-up, 2338 participants died. A 1 SD reduction in grip strength was associated with HR=1.17 (95% CI 1.12 to 1.22) for all- cause mortality in a model adjusted for age, gender and body size. This association was similar across all age groups, in men and women, and robust to adjustment for a range of lifestyle-related and health-related factors. Results for deaths due to cardiovascular disease (CVD), respiratory diseases and external causes resembled those for all-cause mortality, while for cancer, the association was much weaker and not signi fi cant after adjustment for lifestyle-related and health-related factors. <b>Conclusions</b> Weaker grip strength was associated with increased all-cause mortality rates, with similar effects on deaths due to CVD, respiratory disease and external causes, while a much weaker association was observed for cancer-related deaths. These associations were similar in both genders and across age groups, which supports the hypothesis that grip strength might be a biomarker of ageing over the lifespan.en_US
dc.descriptionSource:<a href=http://dx.doi.org/10.1136/jech-2015-206776>http://jech.bmj.com/content/70/12/1214</a>en_US
dc.identifier.citationStrand BH, Cooper R, Bergland A, Jørgensen l, Schirmer H, Skirbekk V, Emaus N. The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study. Journal of Epidemiology and Community Health. 2016;70(12):1214-1221en_US
dc.identifier.cristinIDFRIDAID 1358336
dc.identifier.doi10.1136/jech-2015-206776
dc.identifier.issn0143-005X
dc.identifier.issn1470-2738
dc.identifier.urihttps://hdl.handle.net/10037/10603
dc.language.isoengen_US
dc.publisherBMJ Publishing Group. Journal of Epidemiol Community Healthen_US
dc.relation.journalJournal of Epidemiology and Community Health
dc.relation.urihttp://jech.bmj.com/content/jech/70/12/1214.full.pdf
dc.rights.accessRightsopenAccessen_US
dc.subject.hrcsGenerell helserelevans: Befolkningsundersøkelser
dc.subject.hrcsGeneric Health Relevance : Population screening
dc.subject.en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleThe association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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