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dc.contributor.authorIsaksen, Victoria Therese
dc.contributor.authorLarsen, Maria Arlen
dc.contributor.authorGoll, Rasmus
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorPaulssen, Eyvind Jakob
dc.date.accessioned2017-03-15T11:58:58Z
dc.date.available2017-03-15T11:58:58Z
dc.date.issued2016-09-20
dc.description.abstractBACKGROUND: The metabolic syndrome is a worldwide health issue, with non-alcoholic fatty liver disease (liver steatosis) being one of its features, particularly closely related to insulin resistance. This study aims to investigate whether quantification of hepatic steatosis by abdominal ultrasonography, using hepatorenal index, is a feasible tool for the prediction of insulin resistance, and thus the metabolic syndrome. METHODS: Patients were recruited from the Centre of Obesity at the University Hospital of North Norway, and among participants from the Sixth Tromsø Study. Homeostasis Model Assessment of Insulin Resistance (HOMA1-IR) was measured, body mass index (BMI, kg/m(2)) calculated, and hepatorenal index (HRI), i.e. the ratio of liver to kidney optical densities, was measured by transabdominal ultrasonography. Receiver operating characteristic (ROC) analyses were performed, detecting insulin resistance at HOMA1-IR cut-off values >2.3 and >2.5. RESULTS: Ninety participants were included in the study, of which 46 (51 %) had BMI ≥30 and 27 (30 %) had BMI ≥35. Overall, HRI at level 1.17 had sensitivity 0.90 and specificity 0.70 for predicting insulin resistance (HOMA1-IR >2.3) in all participants. For participants with BMI ≥30, HRI at level 1.17 had sensitivity 0.94 and specificity 0.70, and for BMI ≥35, HRI at level 1.17 had sensitivity 0.93 and specificity 0.75 for predicting HOMA1-IR >2.3. Setting the HRI limit at 1.42 gave low sensitivities and high specificities in all BMI groups. In the analysis predicting HOMA1-IR >2.5, sensitivity values were almost the same as in the analysis predicting HOMA1-IR >2.3, but specificity values were lower in this analysis. CONCLUSION: Detection and quantification of hepatic steatosis by ultrasound and the hepatorenal index is a feasible screening tool for identifying patients with low risk of having insulin resistance (IR, HRI <1.17), patients at risk of having IR (HRI 1.17-1.41) and patients with likely IR (HRI ≥1.42), especially in obese individuals.en_US
dc.description.sponsorshipThis study was funded by the Medical Students’ Research Program, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø,Norway.en_US
dc.description© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.identifier.citationIsaksen VT, Larsen MA, Goll r, Florholmen J, Paulssen EJ. Hepatic Steatosis detected by Hepatorenal Index in Ultrasonography as a Predictor of Insulin Resistance in Obese Subjects. BMC Obesity. 2016;3(39)en_US
dc.identifier.cristinIDFRIDAID 1451941
dc.identifier.doi10.1186/s40608-016-0118-0
dc.identifier.issn2052-9538
dc.identifier.urihttps://hdl.handle.net/10037/10693
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofIsaksen, V.T. (2023). Early Markers of Metabolic Dysregulation in Obese Individuals - Identification at Baseline and Effect of Modest Weight Loss. (Doctoral thesis). <a href=https://hdl.handle.net/10037/31647>https://hdl.handle.net/10037/31647</a>.
dc.relation.journalBMC Obesity
dc.relation.projectIDUniversitetet i Tromsø: Forskerlinjen medisinen_US
dc.relation.urihttps://bmcobes.biomedcentral.com/articles/10.1186/s40608-016-0118-0
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Gastroenterology: 773en_US
dc.subjectVDP::Medisinske fag: 700en_US
dc.subjectVDP::Midical sciences: 700en_US
dc.subjectBody mass indexen_US
dc.subjectHepatorenal indexen_US
dc.subjectHOMA1-IRen_US
dc.subjectInsulin resistanceen_US
dc.subjectLiver steatosisen_US
dc.subjectMetabolic syndromeen_US
dc.subjectMorbid obesityen_US
dc.subjectNon-alcoholic fatty liver diseaseen_US
dc.subjectQuantificationen_US
dc.subjectUltrasonographyen_US
dc.titleHepatic Steatosis detected by Hepatorenal Index in Ultrasonography as a Predictor of Insulin Resistance in Obese Subjectsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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