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dc.contributor.authorVårtun, Åse
dc.contributor.authorFlo, Kari
dc.contributor.authorWidnes, Christian
dc.contributor.authorAcharya, Ganesh
dc.date.accessioned2017-03-15T16:10:41Z
dc.date.available2017-03-15T16:10:41Z
dc.date.issued2016
dc.description.abstractObjective To compare cardiac function, systemic hemodynamics and preload reserve of women with increased (cases) and normal (controls) uterine artery (UtA) pulsatility index (PI) at 22–24 weeks of gestation. Materials and Methods A prospective cross-sectional study of 620 pregnant women. UtA blood flow velocities were measured using Doppler ultrasonography, and PI was calculated. Mean UtA PI ≥ 1.16 (90th percentile) was considered abnormal. Maternal hemodynamics was investigated at baseline and during passive leg raising (PLR) using impedance cardiography (ICG). Preload reserve was defined as percent increase in stroke volume (SV) 90 seconds after passive leg raising compared to baseline. Results Mean UtA PI was 1.49 among cases (n = 63) and 0.76 among controls (n = 557) (p < 0.0001). Eighteen (28.6%) cases and 53 (9.5%) controls developed pregnancy complications (p <0.0001). The mean arterial pressure and systemic vascular resistance were 83 mmHg and 1098.89±293.87 dyne s/cm5 among cases and 79 mmHg and 1023.95±213.83 dyne s/cm5 among controls (p = 0.007 and p = 0.012, respectively). Heart rate, SV and cardiac output were not different between the groups. Both cases and controls responded with a small (4–5%) increase in SV in response to PLR, but the cardiac output remained unchanged. The preload reserve was not significantly different between two groups. Conclusion Pregnant women with abnormal UtA PI had higher blood pressure and systemic vascular resistance, but similar functional hemodynamic profile at 22–24 weeks compared to controls. Further studies are needed to clarify whether functional hemodynamic assessment using ICG can be useful in predicting pregnancy complications.en_US
dc.description.sponsorshipThis study was funded by the Regional Health Authority of Northern Norway (Helse-Nord), Grant No. SFP873/ID1646, GA.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.1371/journal.pone.0157916>http://doi.org/10.1371/journal.pone.0157916</a>. License <a href=https://creativecommons.org/licenses/by/4.0/>CC BY 4.0</a>.en_US
dc.identifier.citationVårtun Å, Flo K, Widnes C, Acharya G. Static and functional hemodynamic profiles of women with abnormal uterine artery doppler at 22-24 weeks of gestation. PLoS ONE. 2016;11:e0157916(6)en_US
dc.identifier.cristinIDFRIDAID 1375612
dc.identifier.doi10.1371/journal.pone.0157916
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/10721
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectHemodynamicsen_US
dc.subjectPregnancyen_US
dc.subjectBlood pressureen_US
dc.subjectPregnancy complicationsen_US
dc.subjectPreeclampsiaen_US
dc.subjectCardiac outputen_US
dc.subjectCardiovascular physiologyen_US
dc.subjectStrokeen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756en_US
dc.titleStatic and functional hemodynamic profiles of women with abnormal uterine artery doppler at 22-24 weeks of gestationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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