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dc.contributor.advisorElin, Richardsen
dc.contributor.authorGrindstad, Thea Karoline Walstad
dc.date.accessioned2017-03-20T10:11:21Z
dc.date.available2017-03-20T10:11:21Z
dc.date.issued2016-10-11
dc.description.abstractAndrogens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays were created from 535 PCa patients treated with radical prostatectomy. Expression of ERα, ERβ and aromatase were evaluated using immunohistochemistry. Representative tumor epithelial (TE) and tumor stromal (TS) areas were investigated separately. Survival analyses were used to evaluate the markers correlation to PCa outcome. In univariate analyses, ERα in TS was associated with delayed time to clinical failure (CF) (p = 0.042) and PCa death (p = 0.019), while ERβ was associated with reduced time to biochemical failure (BF) (p = 0.002). Aromatase in TS and TE was associated with increased time to BF and CF respectively (p = 0.016, p = 0.046). Multivariate analyses supported these observations, indicating an independent prognostic impact of all markers. When stratifying the analysis according to different surgical centers the results were unchanged. In conclusion, significant prognostic roles of ERα, ERβ and aromatase were discovered in the in PCa specimens of our large multicenter cohort.en_US
dc.descriptionMedforfattere: Kaja Skjefstad, SigveAndersen, Nora Ness, Yngve Nordby, SamerAlSaad, Silje Fismen, Tom Dønnem, Mehrdad Rakaee Khanehkenari, Lill-Tove Busund, Roy M. Bremnes & Elin Richardsenen_US
dc.identifier.citationScientific Report (2016) 6:33114en_US
dc.identifier.doihttp://doi.org/10.1038/srep33114
dc.identifier.urihttps://hdl.handle.net/10037/10780
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDMED-3910
dc.subjectTranslasjonell kreftforskningen_US
dc.subjectImmunohistokjemien_US
dc.subjectProstatakreften_US
dc.subjectSteroidhormoneren_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleEstrogen receptors α and β and aromatase as independent predictors for prostate cancer outcomeen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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