Show simple item record

dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorPaulsen, Erna-Elise
dc.contributor.authorRakaee, Mehrdad
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorJohansen Maurseth, Ramona
dc.contributor.authorAl-Shibli, Khalid
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorDønnem, Tom
dc.date.accessioned2017-03-22T09:26:07Z
dc.date.available2017-03-22T09:26:07Z
dc.date.issued2016-04-07
dc.description.abstractbackground: Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who will succumb to, and those who will eventually be cured from, their disease. This novel study: (1) evaluates the presence of different subsets of intraepithelial tumour-infiltrating lymphocytes (TILs) in lymph nodes with metastases from NSCLC patients; (2) explores the impact of intraepithelial TILs in lymph nodes on survival; (3) correlates their presence with both intraepithelial and stromal TILs in their corresponding primary tumours. methods: Metastatic lymph-node tissue from 143N+ NSCLC patients was collected and tissue microarrays were constructed. Immunohistochemistry was used to evaluate the presence of intraepithelial CD3+, CD4+, CD8+, CD20+ and CD45RO+ TILs and their impact on survival. results: A high level of intraepithelial CD45RO+ TILs in lymph-node metastases from N+ NSCLC patients was an independent positive prognostic factor for disease-specific survival in all patients (HR=0.58, P=0.029) and in squamous cell carcinoma (HR=0.31, P=0.006), but not in adenocarcinoma patients. conclusions: The presence of intraepithelial CD45RO+ cells in lymph-node metastases from N+ NSCLC patients predicts favourable disease-specific survival and outperforms the established TNM staging system in the SCC subgroup.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.1038/bjc.2016.92>http://doi.org/10.1038/bjc.2016.92</a>. License <a href=https://creativecommons.org/licenses/by-nc-sa/4.0/>CC BY-NC-SA 4.0</a>.en_US
dc.identifier.citationKilvær et al. The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival. British Journal of Cancer. 2016;114(10):1145-1151en_US
dc.identifier.cristinIDFRIDAID 1371272
dc.identifier.doi10.1038/bjc.2016.92
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/10822
dc.language.isoengen_US
dc.publisherCancer Research UKen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectNSCLCen_US
dc.subjectlung canceren_US
dc.subjectTNM-Ien_US
dc.subjectbiomarkeren_US
dc.subjectlymph-node metastasisen_US
dc.subjectCD45ROen_US
dc.titleThe presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survivalen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record