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dc.contributor.authorDi Cagno, Massimiliano Pio
dc.date.accessioned2017-03-24T09:02:34Z
dc.date.available2017-03-24T09:02:34Z
dc.date.issued2016-12-25
dc.description.abstractCyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins’ legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs.en_US
dc.descriptionPublished version. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-SA 4.0). Source at http://dx.doi.org/10.3390/molecules22010001.en_US
dc.identifier.citationDi Cagno M. The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview. Molecules. 2017;22(1):1-14en_US
dc.identifier.cristinIDFRIDAID 1417662
dc.identifier.doi10.3390/molecules22010001
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/10865
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMolecules
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en_US
dc.subjectcyclodextrinsen_US
dc.subjectinclusion complexesen_US
dc.subjectsolubilizing agentsen_US
dc.subjectcytotoxic activityen_US
dc.subjecthypocholesterolemic agentsen_US
dc.subjectNiemann-Pick Type C disease treatmenten_US
dc.titleThe Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overviewen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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