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dc.contributor.authorAriansen, Inger Kristine
dc.contributor.authorMortensen, Laust Hvas
dc.contributor.authorGraff-Iversen, Sidsel
dc.contributor.authorStigum, Hein
dc.contributor.authorKjøllesdal, Marte Karoline Råberg
dc.contributor.authorNæss, Øyvind
dc.date.accessioned2017-08-03T08:58:45Z
dc.date.available2017-08-03T08:58:45Z
dc.date.issued2017-03-30
dc.description.abstract<p><b>Background:</b> Various indicators of childhood socioeconomic position have been related to cardiovascular disease (CVD) risk in adulthood. We investigated the impact of shared family factors on the educational gradient in midlife CVD risk factors by assessing within sibling similarities in the gradient using a discordant sibling design.</p> <p><b>Methods:</b> Norwegian health survey data (1980–2003) was linked to educational and generational data. Participants with a full sibling in the health surveys (228,346 individuals in 98,046 sibships) were included. Associations between attained educational level (7–9 years, 10–11 years, 12 years, 13–16 years, or >16 years) and CVD risk factor levels in the study population was compared with the corresponding associations within siblings.</p> <p><b>Results:</b> Educational gradients in risk factors were attenuated when factors shared by siblings was taken into account: A one category lower educational level was associated with 0.7 (95% confidence interval 0.6 to 0.8) mm Hg higher systolic blood pressure (27% attenuation), 0.4 (0.4 to 0.5) mmHg higher diastolic blood pressure (30%), 1.0 (1.0 to 1.1) more beats per minute higher heart rate (21%), 0.07 (0.06 to 0.07) mmol/l higher serum total cholesterol (32%), 0.2 (0.2 to 0.2) higher smoking level (5 categories) (30%), 0.15 (0.13 to 0.17) kg/m2 higher BMI (43%), and 0.2 (0.2 to 0.2) cm lower height (52%). Attenuation increased with shorter age-difference between siblings.</p> <p><b>Conclusion:</b> About one third of the educational gradients in modifiable CVD risk factors may be explained by factors that siblings share. This implies that childhood environment is important for the prevention of CVDen_US
dc.identifier.citationBMC Public Health. 2017;17:281en_US
dc.identifier.cristinIDFRIDAID 1465209
dc.identifier.doi10.1186/s12889-017-4123-0
dc.identifier.issn1471-2458
dc.identifier.urihttps://hdl.handle.net/10037/11277
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalBMC Public Health
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372258/pdf/12889_2017_Article_4123.pdf
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectSocioeconomic positionen_US
dc.subjectEducationen_US
dc.subjectCardiovascular disease risk factorsen_US
dc.subjectFamily studyen_US
dc.subjectSiblingsen_US
dc.titleThe educational gradient in cardiovascular risk factors: impact of shared family factors in 228,346 Norwegian siblingsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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