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dc.contributor.advisorFlorholmen, Jon
dc.contributor.advisorPaulssen, Eyvind Jakob
dc.contributor.authorIsaksen, Victoria Therese
dc.date.accessioned2015-04-14T05:08:47Z
dc.date.accessioned2017-10-31T13:20:37Z
dc.date.available2017-10-31T13:20:37Z
dc.date.issued2014-10-31
dc.description.abstractNon-alcoholic fatty liver disease is closely related to the Metabolic syndrome. A significant feature of NAFLD is the presence of hepatic steatosis, which can be assessed by ultrasonography, by measuring the hepatorenal index (HRI), a comparison of liver and kidney acoustic echo densities. This study aims to investigate if HRI can predict insulin resistance. Ninety participants from the obesity clinic and the Sixth Tromsø Study were included. HOMA1-IR, body mass index and HRI were measured. ROC analyses were performed, detecting insulin resistance at HOMA1-IR values 2.3 or 2.5. Groups of participants with BMI ≥30 (n=46) and BMI ≥35 (n=27) were analysed specifically. Results: For BMI ≥30, HRI at level 1.11 had sensitivity=0.94 and specificity=0.54, and HRI=1.42 had sensitivity=0.33 and specificity=0.96. For BMI ≥35, HRI=1.17 had sensitivity=0.93 and specificity=0.77, whereas HRI= 1.42 had a sensitivity of 0.29 and a specificity of 0.92. (All test property values calculated for HOMA1-IR ≥2.3). Conclusion: Mild hepatic steatosis diagnosed by ultrasound is a good predictor for diagnosing insulin resistance, especially in obese patients.en_US
dc.identifier.urihttps://hdl.handle.net/10037/11696
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDMED-3910en_US
dc.subjectGastroenterologyen_US
dc.subjectHepatologyen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773en_US
dc.titleHepatic steatosis detected by ultrasonography as a predictor of insulin resistance in obese patientsen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)