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dc.contributor.authorFortner, Renée T.
dc.contributor.authorVitonis, Allison F.
dc.contributor.authorSchock, Helena
dc.contributor.authorHüsing, Anika
dc.contributor.authorJohnson, Theron
dc.contributor.authorFichorova, Raina Nakove
dc.contributor.authorFashemi, Titilayo
dc.contributor.authorYamamoto, Hidemi S.
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHansen, Louise
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBenetou, Vassiliki
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorMattiello, Amalia
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorJareid, Mie
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorDuell, Eric J.
dc.contributor.authorSánchez, Mariá-José
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorNodin, Björn
dc.contributor.authorBrändstedt, Jenny
dc.contributor.authorIdahl, Annika
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorAllen, Naomi
dc.contributor.authorGunter, Marc
dc.contributor.authorJohansson, Mattias
dc.contributor.authorDossus, Laure
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorRiboli, Elio
dc.contributor.authorCramer, Daniel W.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTerry, Kathryn L.
dc.date.accessioned2018-01-25T08:18:53Z
dc.date.available2018-01-25T08:18:53Z
dc.date.issued2017-03-20
dc.description.abstractBackground: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. <br>Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls ( n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study ( n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. <br>Results: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women ( p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (p trend ≤ 0. 02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking ( p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers ( p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause ( ≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. <br> Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.en_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s13048-017-0315-6> https://doi.org/10.1186/s13048-017-0315-6 </a>en_US
dc.identifier.citationFortner RT. et. al. Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort. Journal of Ovarian Research. 2017;10:20:1-14en_US
dc.identifier.cristinIDFRIDAID 1489017
dc.identifier.doi10.1186/s13048-017-0315-6
dc.identifier.issn1757-2215
dc.identifier.urihttps://hdl.handle.net/10037/12052
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalJournal of Ovarian Research
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleCorrelates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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