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dc.contributor.authorDupont, Laust
dc.contributor.authorEide, Ivar Anders
dc.contributor.authorHartmann, Anders
dc.contributor.authorChristensen, Jeppe Hagstrup
dc.contributor.authorÅsberg, Anders
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorKrarup, Henrik
dc.contributor.authorSvensson, My Hanna Sofia
dc.date.accessioned2018-02-09T08:49:00Z
dc.date.available2018-02-09T08:49:00Z
dc.date.issued2017-09-22
dc.description.abstractBackground:<br> Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2 - 2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. <br>Methods:<br> In this single centre re trospective cohort study of 1975 adult Norwegian RTRs, transplanted between 1999 and 2011, we estimated the risk of all - cause and cardiovascular mortality and overall and death censored graft loss for patients with haptoglobin genotype 2 - 2 compared with genotype 2 - 1 or 1 - 1 , after adjustment for confounders and competing risks. <br>Results: <br> We found no associations between haptoglobin genotype 2 - 2 and cardiovascular mortality (subdistributional hazard ratio [SHR] 1.08, 95% confidence interval [CI] 0.78 - 1.49, p=0.63). We also fail ed to detect any association between haptoglobin 2 - 2 genotype and all - cause mortality, overall graft loss and death censored graft loss. Similar results were found in the subpopulation of diabetic RTRs. <br>Conclusion: <br>In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2 - 2 genotype and patient or graft survival after renal transplantation.en_US
dc.descriptionSubmitted manuscript version. Published version available at <a href=https://doi.org/10.1177/1526924817732020> https://doi.org/10.1177/1526924817732020 </a>.en_US
dc.identifier.citationDupont, L, Eide, I. A., Hartmann, A., Christensen, J. H., Åsberg, A., Jenssen, T., ... Svensson M. H. S. (2017). Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients. Progress in transplantation. 27(4):386-391en_US
dc.identifier.cristinIDFRIDAID 1521757
dc.identifier.doi10.1177/1526924817732020
dc.identifier.issn1526-9248
dc.identifier.issn2164-6708
dc.identifier.urihttps://hdl.handle.net/10037/12108
dc.language.isoengen_US
dc.publisherSage publishingen_US
dc.relation.journalProgress in transplantation
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologisk kirurgi: 781en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroscopic surgery: 781en_US
dc.titleHaptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipientsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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