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dc.contributor.authorAuensen, Andreas
dc.contributor.authorHussain, Amjad
dc.contributor.authorFalk, Ragnhild Sørum
dc.contributor.authorWalle-Hansen, Marte Meyer
dc.contributor.authorBye, Jorun
dc.contributor.authorPettersen, Kjell
dc.contributor.authorUeland, Thor
dc.contributor.authorGullestad, Lars
dc.date.accessioned2018-02-14T10:22:00Z
dc.date.available2018-02-14T10:22:00Z
dc.date.issued2017-06-12
dc.description.abstractObjectives:<br>Among patients with severe aortic stenosis (AS), we investigated the associations of N–terminal pro–natriuretic peptide (NT–proBNP), high–sensitive troponin T (hsTnT), and high–sensitive C–reactive protein (hs–CRP) with 3–year mortality and major adverse cardiovascular events (MACE) during 1 year.<br>Methods:<br>This observational cohort study prospectively enrolled 442 patients with severe AS who were referred for evaluation of possible valve replacement. Clinical data was recorded before the decision of whether to operate was made. We studied the prognostic value of assessing biomarkers by serum levels, and tested associations of NT–proBNP, hsTnT, and hs–CRP with clinical outcomes (3–year all–cause mortality and risk of MACE in the year following study inclusion) using adjusted multivariable analysis.<br>Results:<br>Elevated serum levels of these biomarkers at baseline evaluation were associated with increased all–cause 3–year mortality regardless of treatment assignment. Adjusted analysis showed that none of the studied biomarkers (NT–proBNP, hsTnT or hs–CRP) or any other covariates were associated with 3–year all–cause mortality following surgical aortic valve replacement (SAVR). However, adjusted analyses showed that hsTnT (HR, 1.51; 95% CI, 1.11–2.05; P = 0.008) and left ventricular ejection fraction (HR 0.97; 95% CI 0.94–0.97, P = 0.043) was associated with MACE for operated patients.<br>Conclusions:<br>Whereas NT–proBNP, hsTnT and hs–CRP had no independently prognostic value in relation to all–cause mortality following SAVR, hsTnT was independently associated with MACE following operation. The use of these clinically available biomarkers, in particular hsTnT, should be clarified in larger studies.en_US
dc.descriptionSource at <a href=http://doi.org/10.1371/journal.pone.0179304>http://doi.org/10.1371/journal.pone.0179304</a>en_US
dc.identifier.citationAuensen, A., Hussain, A., Falk, R., Walle-Hansen, M., Bye, J., Pettersen, K., ... Gullestad, L. Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis. PLoS ONE. 2017;12:e0179304(6):1-14en_US
dc.identifier.cristinIDFRIDAID 1501539
dc.identifier.doi10.1371/journal.pone.0179304
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/12165
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleAssociations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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