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dc.contributor.authorRejnmark, Lars
dc.contributor.authorBislev, Lise Sofie
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorEiríksdóttir, Gudny
dc.contributor.authorGaksch, Martin
dc.contributor.authorGrübler, Martin
dc.contributor.authorGrimnes, Guri
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLips, Paul
dc.contributor.authorPilz, Stefan
dc.contributor.authorVan Schoor, Natasja M.
dc.contributor.authorKiely, Mairead
dc.contributor.authorJorde, Rolf
dc.date.accessioned2018-02-14T12:37:06Z
dc.date.available2018-02-14T12:37:06Z
dc.date.issued2017-07-07
dc.description.abstractBackground:<br>A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation.<br>Methods and findings:<br>We identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes. For each outcome, we summarized the results from available SRs and scrutinized included RCTs for a number of predefined characteristics. We identified 54 SRs including data from 210 RCTs. Most MAs as well as the individual RCTs reported null-findings on risk of cardiovascular diseases, type 2 diabetes, weight-loss, and malignant diseases. Beneficial effects of vitamin D supplementation was reported in 1 of 4 MAs on depression, 2 of 9 MAs on blood pressure, 3 of 7 MAs on respiratory tract infections, and 8 of 12 MAs on mortality. Most RCTs have primarily been performed to determine skeletal outcomes, whereas non-skeletal effects have been assessed as secondary outcomes. Only one-third of the RCTs had low level of 25OHD as a criterion for inclusion and a mean baseline 25OHD level below 50 nmol/L was only present in less than half of the analyses.<br>Conclusions:<br>Published RCTs have mostly been performed in populations without low 25OHD levels. The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels.en_US
dc.descriptionSource at <a href=http://doi.org/10.1371/journal.pone.0180512>http://doi.org/10.1371/journal.pone.0180512</a>en_US
dc.identifier.citationRejnmark, L., Bislev, L.S., Cashman, K.D., Eiríksdóttir, G., Gaksch, M., Grübler, M., ... Jorde, R. Non-skeletal health effects of Vitamin D supplementation: A systematic review on findings from meta-Analyses summarizing trial data. PLoS ONE. 2017;12:0180512(7):1-39en_US
dc.identifier.cristinIDFRIDAID 1537143
dc.identifier.doi10.1371/journal.pone.0180512
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/12169
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleNon-skeletal health effects of Vitamin D supplementation: A systematic review on findings from meta-Analyses summarizing trial dataen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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