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dc.contributor.authorShahini, Negar
dc.contributor.authorMichelsen, Annika E.
dc.contributor.authorNilsson, Per H.
dc.contributor.authorEkholt, Karin
dc.contributor.authorGullestad, Lars
dc.contributor.authorBroch, Kaspar
dc.contributor.authorDahl, Christen P.
dc.contributor.authorAukrust, Pål
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorYndestad, Arne
dc.contributor.authorLouwe, Mieke C.
dc.date.accessioned2018-02-28T14:04:57Z
dc.date.available2018-02-28T14:04:57Z
dc.date.issued2017-02-14
dc.description.abstractThe complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured in plasma from 188 HF patients and 67 age- and sex- matched healthy controls by enzyme immunoassay. Our main findings were: (i) Compared to controls, patients with HF had significantly increased levels of factor D and TCC, and decreased levels of properdin, particularly patients with advanced clinical disorder (i.e., NYHA functional class IV), (ii) Levels of factor D and properdin in HF patients were correlated with measures of systemic inflammation (i.e., C-reactive protein), neurohormonal deterioration (i.e., Nt-proBNP), cardiac function, and deteriorated diastolic function, (iii) Low levels of factor H and properdin were associated with adverse outcome in univariate analysis and for factor H, this was also seen in an adjusted model. Our results indicate that dysregulation of circulating components of the alternative pathway explain the increased degree of complement activation and is related to disease severity in HF patients.en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/srep42532> https://doi.org/10.1038/srep42532 </a>.en_US
dc.identifier.citationShahini, N., Michelsen, A.E., Nilsson P.H., Ekholt, K., Gullestad, L., Broch, K. ... Louwe, M.C. The alternative complement pathway is dysregulated in patients with chronic heart failure. (2017). Scientific Reports. 7:42532.en_US
dc.identifier.cristinIDFRIDAID 1473330
dc.identifier.doi10.1038/srep42532
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/12228
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectChronic inflammationen_US
dc.subjectHeart failureen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.titleThe alternative complement pathway is dysregulated in patients with chronic heart failureen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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