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dc.contributor.authorEkelund, Maria
dc.contributor.authorAalto, Kristiina
dc.contributor.authorFasth, Anders
dc.contributor.authorNielsen, Susan
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorRygg, Marite
dc.contributor.authorZak, Marek
dc.contributor.authorBerntson, Lillemor
dc.date.accessioned2018-03-15T12:32:58Z
dc.date.available2018-03-15T12:32:58Z
dc.date.issued2017-02-22
dc.description.abstractBackground<br> To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).<p> Methods<br> In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children. The presence of psoriasis, psoriasis-like rash, dactylitis, nail pitting, enthesitis, tenosynovitis and heredity was assessed in relation to ILAR classification and remission.<p> Results<br> Clinical findings associated with psoriasis developed consecutively during the 8-year period. Six of 14 children with psoriasis were not classified as juvenile psoriatic arthritis according to the ILAR criteria at 8 year follow-up. Dactylitis was more common in children with early onset of JIA. After 8 years we found a cumulative median number of eleven arthritic joints in children with psoriasis or psoriasis-like rash compared with six in the rest of the cohort (p = 0.02). Also, the chance for not being in remission after 8 years increased significantly in patients with psoriasis, psoriasis-like rash or at least two of: 1) first-degree heredity for psoriasis or psoriatic arthritis, 2) dactylitis or 3) nail pitting, compared with the rest of the group (OR 3.32, p = 0.010).<p> Conclusions<br> Our results indicate a more severe disease over time in psoriasis-associated JIA, as features of psoriasis develop during the disease course. This group is a major challenge to encompass in a future JIA classification in order to facilitate early tailored treatment.en_US
dc.description.sponsorshipDepartment of Women’s and Children’s Health, Uppsala University Hospital Gillbergska foundation Futurum - academy of health and care Region Jönköping county Swedish Rheumatism associationen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12969-017-0145-5> https://doi.org/10.1186/s12969-017-0145-5 </a>.en_US
dc.identifier.citationEkelund, M., Aalto, K., Fasth, A., Herlin, T., Nielsen, S., Nordal, E.B. ... Berntson, L. (2017). Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study. Pediatric Rheumatology, 15(13).en_US
dc.identifier.cristinIDFRIDAID 1485171
dc.identifier.doi10.1186/s12969-017-0145-5
dc.identifier.issn1546-0096
dc.identifier.urihttps://hdl.handle.net/10037/12345
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalPediatric Rheumatology
dc.rights.accessRightsopenAccessen_US
dc.subjectArthritisen_US
dc.subjectJuvenile Rheumatoiden_US
dc.subjectPsoriasisen_US
dc.subjectChilden_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Pediatri: 760en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760en_US
dc.titlePsoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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