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dc.contributor.authorBye, Asta
dc.contributor.authorSjøblom, Bjørg
dc.contributor.authorWentzel-Larsen, Tore
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorBaracos, Vickie E.
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorAass, Nina Kathrine
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorFløtten, Øystein
dc.contributor.authorJordhøy, Marit Slaaen
dc.date.accessioned2018-03-20T09:01:55Z
dc.date.available2018-03-20T09:01:55Z
dc.date.issued2017-05-10
dc.description.abstractBackground<br> Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) and selected QoL outcomes in advanced non‐small cell lung cancer (NSCLC) at diagnosis.<p> Methods<br> Baseline data from patients with stage IIIB/IV NSCLC and performance status 0–2 enrolled in three randomized trials of first‐line chemotherapy (n = 1305) were analysed. Associations between SMI (cm2/m2) and SMD (Hounsfield units) based on computed tomography‐images at the third lumbar level and self‐reported physical function (PF), role function (RF), global QoL, fatigue, and dyspnoea were investigated by linear regression using flexible non‐linear modelling.<p> Results<br> Complete data were available for 734 patients, mean age 65 years. Mean SMI was 47.7 cm2/m2 in men (n = 420) and 39.6 cm2/m2 in women (n = 314). Low SMI values were non‐linearly associated with low PF and RF (men P = 0.016/0.020, women P = 0.004/0.012) and with low global QoL (P = 0.001) in men. Low SMI was significantly associated with high fatigue (P = 0.002) and more pain (P = 0.015), in both genders, but not with dyspnoea. All regression analyses showed poorer physical outcomes below an SMI breakpoint of about 42–45 cm2/m2 for men and 37–40 cm2/m2 for women. In both genders, poor PF and more dyspnoea were significantly associated with low SMD.<p> Conclusions<br> Low muscle mass in NSCLC negatively affects the patients' PF, RF, and global QoL, possibly more so in men than in women. However, muscle mass must be below a threshold value before this effect can be detected.en_US
dc.descriptionSource at <a href=https://doi.org/10.1002/jcsm.12206> https://doi.org/10.1002/jcsm.12206 </a>.en_US
dc.identifier.citationBye, A., Sjøblom, B., Wentzel-Larsen, T., Grønberg, B.H., Baracos, V.E., Hjermstad, M.J. ... Jordhøy, M.S. (2017). Muscle mass and association to quality of life in non-small cell lung cancer patients. Journal of Cachexia, Sarcopenia and Muscle, 8(5), 759-767.en_US
dc.identifier.cristinIDFRIDAID 1515725
dc.identifier.doi10.1002/jcsm.12206
dc.identifier.issn2190-5991
dc.identifier.issn2190-6009
dc.identifier.urihttps://hdl.handle.net/10037/12384
dc.language.isoengen_US
dc.publisherWiley Open Accessen_US
dc.relation.journalJournal of Cachexia, Sarcopenia and Muscle
dc.rights.accessRightsopenAccessen_US
dc.subjectNon-small cell lung canceren_US
dc.subjectQuality of lifeen_US
dc.subjectBody compositionen_US
dc.subjectMuscle massen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleMuscle mass and association to quality of life in non-small cell lung cancer patientsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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