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dc.contributor.authorCaini, Saverio
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSaieva, Calogero
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorSavoye, Isabelle
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorHemmingsson, Oskar
dc.contributor.authorHammer Bech, Bodil
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPetersen, Kristina E.N.
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCervenka, Iris
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorFloegel, Anna
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorValanou, Elisavet
dc.contributor.authorKritikou, Maria
dc.contributor.authorTagliabue, Giovanna
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorVeierød, Marit Bragelien
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorLukic, Marko
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSalamanca Fernández, Elena
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorMaria Nilsson, Lena
dc.contributor.authorLjuslinder, Ingrid
dc.contributor.authorJirström, Karin
dc.contributor.authorSonestedt, Emily
dc.contributor.authorKey, Timothy J.
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorMurphy, Neil
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorPalli, Domenico
dc.date.accessioned2018-03-22T09:22:24Z
dc.date.available2018-03-22T09:22:24Z
dc.date.issued2017-02-20
dc.description.abstractIn vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country‐specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow‐up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non‐consumers 0.31, 95% CI 0.14–0.69) but not among women (HR 0.96, 95% CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.en_US
dc.description.sponsorshipMutuelle Générale de l'Education Nationale (MGEN) European Community French League Against Cancer (LNCC) Gustave Roussy French Institute of Health and Medical research (INSERM) EPIC‐Greece was supported by the Hellenic Health Foundation EPIC Norfolk is from Medical Research Council UK and Cancer Research UK Italian Association for Cancer Research (AIRC)en_US
dc.descriptionThis is the peer reviewed version of the following article: Caini, S., Masala, G., Saieva, C., Kvaskoff, M., Savoye, I., Sacerdote, C. ... Palli, D. (2017) Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 140(10):2246-2255, which has been published in final form at <a href=http://dx.doi.org/10.1002/ijc.30659> http://dx.doi.org/10.1002/ijc.30659 </a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.identifier.citationCaini, S., Masala, G., Saieva, C., Kvaskoff, M., Savoye, I., Sacerdote, C. ... Palli, D. (2017) Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 140(10):2246-2255en_US
dc.identifier.cristinIDFRIDAID 1488886
dc.identifier.doi10.1002/ijc.30659
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/12411
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectcoffeeen_US
dc.subjectteaen_US
dc.subjectmelanoma risken_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Dermatologi og venerologi: 753en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Dermatology and venereology: 753en_US
dc.titleCoffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutritionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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