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dc.contributor.authorLekva, Tove
dc.contributor.authorMichelsen, Annika E.
dc.contributor.authorAukrust, Pål
dc.contributor.authorHenriksen, Tore
dc.contributor.authorJens, Bollerslev
dc.contributor.authorUeland, Thor
dc.date.accessioned2018-05-02T08:54:44Z
dc.date.available2018-05-02T08:54:44Z
dc.date.issued2017-01-10
dc.description.abstractBackground: Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy. <br> <br> Methods: This population-based prospective cohort included 300 women who had an oral glucose tolerance test (OGTT) during pregnancy. Five years later, the OGTT was repeated along with dual-energy X-ray absorptiometry, lipid analysis, and pulse wave velocity analysis. Fasting adiponectin and leptin levels were measured four times during pregnancy and at follow-up. <br> <br> Results: We found the L/A ratio higher in GDM women during both pregnancy and follow-up compared to nonGDM women. A high L/A ratio during pregnancy was associated with CV risk based on lipid ratios at follow-up, especially the TG/HDL-C ratio. Further, interaction analysis indicated that an increase in the L/A ratio of 1 unit was associated with a higher CV risk in GDM compared to normal pregnancy. Finally, low adiponectin levels independently predicted increased lipid ratios at follow-up. <br> <br> Conclusions: Taken together, our findings suggest that high L/A ratio in pregnancy and in particularly in those with GDM are associated with an unfavorable CVD risk profile during follow-up. Future studies should investigate if a dysregulated leptin and adiponectin profile during pregnancy is associated with atherosclerotic disease during long-term follow-up.en_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12933-016-0492-4>https://doi.org/10.1186/s12933-016-0492-4</a>.en_US
dc.identifier.citationLekva, T., Michelsen, A.E., Aukrust, P., Henriksen, T., Bollerslev, J., & Ueland, T. (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology,16:(1):5. https://doi.org/10.1186/s12933-016-0492-4en_US
dc.identifier.cristinIDFRIDAID 1473125
dc.identifier.doi10.1186/s12933-016-0492-4
dc.identifier.issn1475-2840
dc.identifier.urihttps://hdl.handle.net/10037/12656
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.publisherSpringer Verlagen_US
dc.relation.journalCardiovascular Diabetology
dc.relation.urihttps://cardiab.biomedcentral.com/articles/10.1186/s12933-016-0492-4
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en_US
dc.subjectGDMen_US
dc.subjectCVDen_US
dc.subjectLeptinen_US
dc.subjectAdiponectinen_US
dc.titleLeptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitusen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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