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dc.contributor.authorNieder, Carsten
dc.contributor.authorLangendijk, Johannes A.
dc.contributor.authorGuckenberger, Matthias
dc.contributor.authorGrosu, Anca L.
dc.date.accessioned2018-06-14T10:29:31Z
dc.date.available2018-06-14T10:29:31Z
dc.date.issued2017-02-21
dc.description.abstractThe purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. <br> <br> Methods and materials: We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many cases. <br> <br> Results: Both hematological malignancies and solid tumors were treated with a second course of radiation therapy, and indications included local relapse, regional nodal recurrence, and second primary tumors developing in a previously treated region. The literature consists of retrospective single-institution analyses describing treatment approaches that included external beam radiation therapy, brachytherapy, or combinations thereof. Data on toxicities and survival were often provided. Breast cancer and gynecological, head and neck, brain, and skin tumors are among the entities included in this review. <br> <br> Conclusions: The leading pioneers in the field are fully aware of many of the challenges we continue to debate today. These include the process of late tissue changes and development of personalized treatment approaches and better ways to select patients who are likely to benefit from a second course of radiation therapy.en_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.adro.2017.02.005>https://doi.org/10.1016/j.adro.2017.02.005 </a>.en_US
dc.identifier.citationNieder, C., Langendijk, J.A., Guckenberger, M. & Grosu, A.L.(2017). Preserving the legacy of reirradiation: A narrative review of historical publications. Advances in Radiation Oncology, 2(2), 176-182. https://doi.org/10.1016/j.adro.2017.02.005en_US
dc.identifier.cristinIDFRIDAID 1484861
dc.identifier.doi10.1016/j.adro.2017.02.005
dc.identifier.issn2452-1094
dc.identifier.urihttps://hdl.handle.net/10037/12867
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalAdvances in Radiation Oncology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Radiology and diagnostic imaging: 763en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titlePreserving the legacy of reirradiation: A narrative review of historical publicationsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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