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dc.contributor.authorArshad, Nadia
dc.contributor.authorIsaksen, Trond
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2018-06-27T08:23:04Z
dc.date.available2018-06-27T08:23:04Z
dc.date.issued2017-03-17
dc.description.abstractChanges in the incidence of venous thromboembolism (VTE) during the last two decades have not been extensively studied. Therefore, we studied time trends in the incidence rates (IRs) of deep vein thrombosis (DVT) and pulmonary embolism (PE) in a cohort of 26,855 subjects, aged 25–97 years, enrolled in the Tromsø study in 1994/1995. The subject were followed-up throughout 2012, and all symptomatic, objectively confirmed, incident VTEs were identified using multiple sources (hospital discharge-, radiology procedure- and autopsy registry) and validated by review of medical records. Age-adjusted biennial IR per 100,000 person years (PY) with 95% confidence intervals (CI) were calculated using Poisson regression. Between January 1996 and December 2012, 693 VTEs occurred during 368,150 PY of follow up. The IR of VTE increased from 158 (95% CI 116–199) in 1996/1997 to 201 (95% CI 160–243) in 2010/2011. There was a marked increase in the rates of PE (with/without concurrent DVT) ranging from 45 (95% CI 23–67) in 1996/1997 to 113 (95% CI 82–144) in 2010/2011, whereas the rates of isolated DVT decreased (112, 95% CI 77–146 in 1996/1997 and 88, 95% CI 61–115 in 2010/2011). Despite advances in prophylaxis, the IR of VTE has increased slightly during the last 15 years, mainly due to an increase in PE. Although the introduction of better diagnostic tools to some extent may explain the increase in PE rates, our findings suggest that there is still a need for improvement in risk factor management and prevention strategies of first time VTE.en_US
dc.description.sponsorshipStiftelsen K.G. Jebsenen_US
dc.descriptionThis is a pre-print of an article published in European Journal of Epidemiology. The final authenticated version is available online at: <a href=https://doi.org/10.1007/s10654-017-0238-y> https://doi.org/10.1007/s10654-017-0238-y </a>.en_US
dc.identifier.citationArshad, N., Isaksen, T., Hansen, J.B. & Brækkan, S.K. (2017). Time trends in incidence rates of venous thromboembolism in a large cohort recruited from the general population. European Journal of Epidemiology. 32(4), 299-305. https://doi.org/10.1007/s10654-017-0238-yen_US
dc.identifier.cristinIDFRIDAID 1487655
dc.identifier.doi10.1007/s10654-017-0238-y
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.urihttps://hdl.handle.net/10037/13015
dc.language.isoengen_US
dc.publisherSpringer Verlag (Germany)en_US
dc.relation.journalEuropean Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectVenous thromboembolismen_US
dc.subjectIncidenceen_US
dc.subjectDeep vein thrombosisen_US
dc.subjectPulmonary embolismen_US
dc.titleTime trends in incidence rates of venous thromboembolism in a large cohort recruited from the general populationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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