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dc.contributor.authorHansen, Merethe Selnes
dc.contributor.authorLicaj, Idlir
dc.contributor.authorBraaten, Tonje
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorMarchand, Loic Le
dc.contributor.authorGram, Inger Torhild
dc.date.accessioned2018-07-23T11:07:34Z
dc.date.available2018-07-23T11:07:34Z
dc.date.issued2017-10-26
dc.description.abstractWhether women are more susceptible than men to smoking-related lung cancer has been a topic of controversy. To address this question, we compared risks of lung cancer associated with smoking by sex. Altogether, 585,583 participants from 3 Norwegian cohorts (Norwegian Counties Study, 40 Years Study, and Cohort of Norway (CONOR) Study) were followed until December 31, 2013, through linkage of data to national registries. We used Cox proportional hazards models and 95% confidence intervals to estimate risks. During nearly 12 million person-years of follow-up, 6,534 participants (43% women) were diagnosed with lung cancer. More men than women were heavier smokers. Compared with never smokers, male and female current smokers with ≥16 pack-years of smoking had hazard ratios for lung cancer of 27.24 (95% confidence interval (CI): 22.42, 33.09) and 23.90 (95% CI: 20.57, 27.76), respectively (P for heterogeneity = 0.30). In contrast, for current smokers, in a model with pack-years measured continuously, men had a hazard ratio of 1.43 (95% CI: 1.39, 1.48) and women a hazard ratio of 1.64 (95% CI: 1.57, 1.71) for each 10–pack-year increment of smoking (P for heterogeneity < 0.01). Our results suggest that women have an increased susceptibility to lung cancer compared with men, given the same lifetime smoking exposure.en_US
dc.description.sponsorshipNorthern Norway Health Authority Norwegian Cancer Societyen_US
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record [insert complete citation information here] is available online at: <a href=https://doi.org/10.1093/aje/kwx339> https://doi.org/10.1093/aje/kwx339</a>.en_US
dc.identifier.citationHansen, M.S., Licaj, I., Braaten, T., Langhammer, A., Le Marchand, L. & Gram, I.T. (2018). Sex differences in risk of smoking-related lung cancer: results from a cohort of 600,000 Norwegians. <i>American Journal of Epidemiology, 187</i>(5), 971-981. https://doi.org/10.1093/aje/kwx339en_US
dc.identifier.cristinIDFRIDAID 1511912
dc.identifier.doi10.1093/aje/kwx339
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.urihttps://hdl.handle.net/10037/13246
dc.language.isoengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofHansen, M.S. (2020). Aspects of Lung Cancer by Sex. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18465>https://hdl.handle.net/10037/18465 </a>.
dc.relation.journalAmerican Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectcohort studiesen_US
dc.subjectCohort of Norway (CONOR) Studyen_US
dc.subjecthistologyen_US
dc.subjectlung neoplasmsen_US
dc.subjectsex differencesen_US
dc.subjectsmokingen_US
dc.subjectsmokingen_US
dc.subjectheterogeneityen_US
dc.subjectfollow-upen_US
dc.subjectnorwayen_US
dc.subjectsex characteristicsen_US
dc.subjectlung canceren_US
dc.subjectnorwegianen_US
dc.subjectsmokersen_US
dc.titleSex differences in risk of smoking-related lung cancer: results from a cohort of 600,000 Norwegiansen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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