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dc.contributor.authorCsifcsak, Gabor
dc.contributor.authorBoayue, Nya Mehnwolo
dc.contributor.authorPuonti, Oula
dc.contributor.authorThielscher, Axel
dc.contributor.authorMittner, Matthias
dc.date.accessioned2018-08-02T11:33:15Z
dc.date.available2018-08-02T11:33:15Z
dc.date.issued2018-02-28
dc.description.abstract<p><i>Background</i>: Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data.</p> <p><i>Methods</i>: We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD patients and applied computational modeling to simulate the spatial distribution of tDCS-induced electric fields (EFs) in 20 frontal regions. We evaluated effects of seven bipolar and two multi-electrode 4 × 1 tDCS protocols.</p> <p><i>Results</i>: For bipolar montages, EFs were of comparable strength in the lDLPFC and in the medial prefrontal cortex (MPFC). Depending on stimulation parameters, EF cortical maps varied to a considerable degree, but were found to be similar in controls and patients. 4 × 1 montages produced more localized, albeit weaker effects.</p> <p><i>Limitations</i>: White matter anisotropy was not modeled. The relationship between EF strength and clinical response to tDCS could not be evaluated.</p> <p><i>Conclusions</i>: In addition to lDLPFC stimulation, excitability changes in the MPFC should also be considered as a potential mechanism underlying clinical efficacy of bipolar montages. MDD-associated anatomical variations are not likely to substantially influence current flow. Individual modeling of tDCS protocols can substantially improve cortical targeting. We make recommendations for future research to explicitly test the contribution of lDLPFC vs. MPFC stimulation to therapeutic outcomes of tDCS in this disorder.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority The Lundbeck Foundation The Novonordisk Foundationen_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.jad.2018.02.077> https://doi.org/10.1016/j.jad.2018.02.077</a>. Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationCsifcsak, G., Boayue, N.M., Puonti, O., Thielscher, A. & Mittner, M. (2018). Effects of transcranial direct current stimulation for treating depression: A modeling study. Journal of Affective Disorders, 234, 164-173. https://doi.org/10.1016/j.jad.2018.02.077en_US
dc.identifier.cristinIDFRIDAID 1575933
dc.identifier.doi10.1016/j.jad.2018.02.077
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.urihttps://hdl.handle.net/10037/13338
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofBoayue, N.M. (2020). Understanding the Neural and Behavioral Correlates of Mind Wandering Through Transcranial Direct Current Stimulation. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18965>https://hdl.handle.net/10037/18965</a>.
dc.relation.journalJournal of Affective Disorders
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Kognitiv psykologi: 267en_US
dc.subjectVDP::Social science: 200::Psychology: 260::Cognitive psychology: 267en_US
dc.subjectTranscranial direct current stimulationen_US
dc.subjecttDCSen_US
dc.subjectDepressionen_US
dc.subjectComputational modelingen_US
dc.subjectDorsolateral prefrontal cortexen_US
dc.subjectMedial prefrontal cortexen_US
dc.titleEffects of transcranial direct current stimulation for treating depression: A modeling studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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