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dc.contributor.authorFjellaksel, Richard
dc.contributor.authorDugalic, Damir
dc.contributor.authorDemissie, Taye Beyene
dc.contributor.authorRiss, Patrick
dc.contributor.authorHjelstuen, Ole Kristian
dc.contributor.authorSundset, Rune
dc.contributor.authorHansen, Jørn H
dc.date.accessioned2018-08-16T09:14:20Z
dc.date.available2018-08-16T09:14:20Z
dc.date.issued2018-02-28
dc.description.abstractHerein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest for radioiodination of amine‐containing bioactives. The mechanistic details of the iodination process were studied by kinetics and density functional theory calculations, which revealed the mechanistic complexity of the reaction involving amide group anchimeric assistance. We disclose a number of fundamental aspects of amide group anchimeric assistance in substitution reactions.en_US
dc.description.sponsorshipHelse Nord The Department of Chemistry at UiT The Arctic University of Norwayen_US
dc.descriptionThis is the peer reviewed version of the following article: Fjellaksel, R., Dugalic, D., Demissie, T.B., Riss, P., Hjelstuen, O.-K., Sundset, R. & Hansen, J.H. (2018). An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance. Journal of Physical Organic Chemistry. https://doi.org/10.1002/poc.3835, which has been published in final form at <a href=https://doi.org/10.1002/poc.3835> https://doi.org/10.1002/poc.3835</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationFjellaksel, R., Dugalic, D., Demissie, T.B., Riss, P., Hjelstuen, O.-K., Sundset, R. & Hansen, J.H. (2018). An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance. Journal of Physical Organic Chemistry. https://doi.org/10.1002/poc.3835en_US
dc.identifier.cristinIDFRIDAID 1560383
dc.identifier.doihttps://doi.org/10.1002/poc.3835
dc.identifier.issn0894-3230
dc.identifier.issn1099-1395
dc.identifier.urihttps://hdl.handle.net/10037/13421
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Physical Organic Chemistry
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectamide anchimeric assistanceen_US
dc.subjectbioactivesen_US
dc.subjectDFT mechanismen_US
dc.subjectFinkelsteinen_US
dc.subjectradioiodinationen_US
dc.titleAn Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistanceen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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