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dc.contributor.authorHald, Erin Mathiesen
dc.contributor.authorRinde, Ludvig Balteskard
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorNjølstad, Inger
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2018-08-21T14:02:28Z
dc.date.available2018-08-21T14:02:28Z
dc.date.issued2018-01-29
dc.description.abstract<p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> <p><i>Methods and Results</i>: We observed 29 842 participants from 3 surveys of the Tromsø study (inclusion in 1994–1995, 2001–2002, and 2007–2008) to the end of 2012. Incident events of AF, IS, and PE during follow‐up were recorded, and information on potential confounders was obtained at baseline. Cox regression models, with AF as a time‐dependent variable, were used to calculate cause‐specific hazard ratios (HRs) with 95% confidence intervals (CIs) for PE and IS. There were 2067 participants diagnosed as having AF, 296 with PE and 1164 with IS, during a median of 17.6 years of follow‐up. The risks of PE (HR, 10.88; 95% CI, 6.23–18.89) and IS (HR, 6.16; 95% CI, 4.47–8.48) were substantially increased during the first 6 months after AF diagnosis, with crude incidence rates of 18.5 per 1000 person‐years for PE and 52.8 per 1000 person‐years for IS. The risk estimates remained elevated for both PE (HR, 1.72; 95% CI, 1.10–2.71) and IS (HR, 2.45; 95% CI, 2.05–2.92) throughout the study period.</p> <p><i>Conclusions</i>: AF was associated with increased cause‐specific risks of both PE and IS. Our findings infer that the risk of PE in AF is not explained by intermediate IS.en_US
dc.description.sponsorshipK. G. Jebsen Foundation UiT The Arctic University of Norwayen_US
dc.descriptionSource at <a href=https://doi.org/10.1161/JAHA.117.006502> https://doi.org/10.1161/JAHA.117.006502</a>.en_US
dc.identifier.citationHald, E.M., Rinde, L.B., Løchen, M.-L., Mathiesen, E.B., Wilsgaard, T., Njølstad, I., ... Hansen, J.B. (2018). Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke. Journal of the American Heart Association, 7(3), 1-8. https://doi.org/10.1161/JAHA.117.006502en_US
dc.identifier.cristinIDFRIDAID 1564410
dc.identifier.doi10.1161/JAHA.117.006502
dc.identifier.issn2047-9980
dc.identifier.urihttps://hdl.handle.net/10037/13516
dc.language.isoengen_US
dc.publisherWiley Open Accessen_US
dc.relation.journalJournal of the American Heart Association
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectischemic strokeen_US
dc.subjectpulmonary embolismen_US
dc.subjectepidemiologyen_US
dc.subjectatrial fibrillationen_US
dc.subjectrisk factoren_US
dc.titleAtrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Strokeen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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